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CTCF interacts with and recruits the largest subunit of RNA polymerase II to CTCF target sites genome-wide 下载免费PDF全文
Chernukhin I Shamsuddin S Kang SY Bergström R Kwon YW Yu W Whitehead J Mukhopadhyay R Docquier F Farrar D Morrison I Vigneron M Wu SY Chiang CM Loukinov D Lobanenkov V Ohlsson R Klenova E 《Molecular and cellular biology》2007,27(5):1631-1648
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‘Structural maintenance of chromosomes’ (SMC) complexes are required for the folding of genomic DNA into loops. Theoretical considerations and single-molecule experiments performed with the SMC complexes cohesin and condensin indicate that DNA folding occurs via loop extrusion. Recent work indicates that this process is essential for the assembly of antigen receptor genes by V(D)J recombination in developing B and T cells of the vertebrate immune system. Here, I review how recent studies of the mouse immunoglobulin heavy chain locus Igh have provided evidence for this hypothesis and how the formation of chromatin loops by cohesin and regulation of this process by CTCF and Wapl might ensure that all variable gene segments in this locus (VH segments) participate in recombination with a re-arranged DJH segment, to ensure generation of a maximally diverse repertoire of B-cell receptors and antibodies. 相似文献
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