共查询到20条相似文献,搜索用时 31 毫秒
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HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure 总被引:172,自引:0,他引:172
Productive infection of human T lymphocytes by HIV-1 is dependent upon proliferation of the infected cell. Nonproliferating quiescent T cells can be infected by HIV-1 and harbor the virus in an inactive state until subsequent mitogenic stimulation. We use a modification of the polymerase chain reaction method, which is both sensitive and quantitative, to demonstrate that HIV-1 DNA synthesis is initiated in infected quiescent T cells at levels comparable with those of activated T cells. However, unlike that of activated T cells, the viral genome is not completely reverse transcribed in quiescent cells. Although this viral DNA structure can persist in quiescent cells as a latent form, it is labile. We discuss the lability of this HIV-1 DNA structure in relation to a "self-restricting persistent infection" by HIV-1 and propose that this may explain the low percentage of infected cells in the circulation of AIDS patients. 相似文献
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Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue 总被引:2,自引:0,他引:2 下载免费PDF全文
Biancotto A Grivel JC Gondois-Rey F Bettendroffer L Vigne R Brown S Margolis LB Hirsch I 《Journal of virology》2004,78(19):10507-10515
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A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells. 总被引:8,自引:2,他引:6 下载免费PDF全文
J M Leiden C Y Wang B Petryniak D M Markovitz G J Nabel C B Thompson 《Journal of virology》1992,66(10):5890-5897
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