Special Issue on“Biomarkers for Diseases”

<正>The journal Genomics ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the fall 2015)on the topic of‘‘Biomarkers for Diseases’’. As an emerging index,disease biomarkers have demonstrated the potential application in     

Special Issue on“Biomarkers for Diseases”

<正>The journal Genomics ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the winter of 2015)on the topic of‘‘Biomarkers for Diseases’’.As an emerging index,disease biomarkers have demonstrated the potential application in diagnosis and prognosis.The detection of the disease indicators at molecular level,DNA,     

Special Issue on “Biomarkers for Human Diseases and Translational Medicine”

正The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the Spring of 2017)on the topic of‘‘Biomarkers for Human Diseases and Translational Medicine’’.In the personalized medicine era,disease biomarkers have potential application in diagnosis,prognosis,and guidance for treatment,and are important tools in translational medicine.     

Special Issue on “Biomarkers for Human Diseases and Translational Medicine”

正The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the fall of 2016)on the topic of‘‘Biomarkers for Human Diseases and Translational Medicine’’.In the personalized medicine era,disease biomarkers have potential application in diagnosis,     

Special Issue on “Biomarkers for Human Diseases and Translational Medicine”

正The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions for a special issue(to be published in the fall of 2016)on the topic of‘‘Biomarkers for Human Diseases and Translational Medicine’’.In the personalized medicine era,disease biomarkers have potential application in diagnosis,prognosis,and guidance for treatment,and are important tools in translational medicine.     

Special Issue on “Microbiome and Health”

<正>The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions to a special issue(to be published in the Fall of 2017)on the topic of‘‘Microbiome and Health’’.In the era of precision medicine,the human‘‘2ndgenome’’,namely the human microbiome,is of increasing interest worldwide.Firstly,the human microbiome has been linked to various     

Special Issue on “Microbiome and Health”

正The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions to a special issue(to be published in the fall of 2018)on the topic of‘‘Microbiome and Health’’.In the era of precision medicine,the humannamely the human microbiome,is of increasing interest worldwide.Firstly,the human microbiome has been linked to various diseases including metabolic diseases,cancers,heart diseases,or brain disorders,and autoimmune diseases.Secondly,changes in the microbiome are known or hypothesized to be proxies for environmental or host phenotypical changes.Thirdly,the rational alteration of disturbed human     

Special Issue on “Microbiome and Health”

正The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions to a special issue(to be published in the Fall of 2017)on the topic ofMicrobiome and Health.In the era of precision medicine,the human 2ndgenome,namely the human microbiome,is of increasing interest worldwide.Firstly,the human microbiome has been linked to various diseases including metabolic diseases,cancers,heart diseases,or brain disorders,and autoimmune     

Special Issue on “Microbiome and Health”

<正>The journal Genomics,ProteomicsBioinformatics(GPB)is now inviting submissions to a special issue(to be published in the summer of 2018)on the topic ofMicrobiome and Health.In the era of precision medicine,the human 2~(nd) genome,namely the human microbiome,is of     

Synthesis of pyrimidine-2,4,6-trione derivatives: Anti-oxidant,anti-cancer, α-glucosidase, β-glucuronidase inhibition and their molecular docking studies

This paper describes a facile protocol, efficient, and environmentally benign for the synthesis a series of barbiturate acid substituted at C5 position 3a–o. The desired compounds subjected in vitro for different set of bioassays including against anti-oxidant (DPPH and super oxide scavenger assays), anti-cancer, α-glucosidase and β-glucuronidase inhibitions. Compound 3m (IC₅₀ = 22.9 ± 0.5 μM) found to be potent α-glucosidase enzyme inhibitors and showed more activity than standard acarbose (IC₅₀ = 841 ± 1.73 μM). Compound 3f (IC₅₀ = 86.9 ± 4.33 μM) found to be moderate β-Glucuronidase enzyme inhibitors and showed activity comparatively less than the standard d-saccharic acid 1,4-lactone (IC₅₀ = 45.75 ± 2.16 μM). Furthermore, in sillico investigation was carried out to investigate bonding mode of barbiturate acid derivatives.