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Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway 总被引:19,自引:0,他引:19
Isaacs JS Jung YJ Mimnaugh EG Martinez A Cuttitta F Neckers LM 《The Journal of biological chemistry》2002,277(33):29936-29944
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Makino Y Uenishi R Okamoto K Isoe T Hosono O Tanaka H Kanopka A Poellinger L Haneda M Morimoto C 《The Journal of biological chemistry》2007,282(19):14073-14082
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HIF-1alpha is essential for myeloid cell-mediated inflammation 总被引:66,自引:0,他引:66
Cramer T Yamanishi Y Clausen BE Förster I Pawlinski R Mackman N Haase VH Jaenisch R Corr M Nizet V Firestein GS Gerber HP Ferrara N Johnson RS 《Cell》2003,112(5):645-657
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The hypoxia-inducible factor-1 (HIF-1) is the master regulator of the cellular response to hypoxia and its expression levels are tightly controlled through synthesis and degradation. It is widely accepted that HIF-1alpha protein accumulation during hypoxia results from inhibition of its oxygen-dependent degradation by the von Hippel Lindau protein (pVHL) pathway. However, recent data describe new pVHL- or oxygen-independent mechanisms for HIF-1alpha degradation. Furthermore, the hypoxia-induced increase in HIF-1alpha levels is facilitated by the continued translation of HIF-1alpha during hypoxia despite the global inhibition of protein translation. Recent work has contributed to an increased understanding of the mechanisms that control the translation and degradation of HIF-1alpha under both normoxic and hypoxic conditions. 相似文献