共查询到20条相似文献,搜索用时 31 毫秒
1.
MJoseph Scobey Elizabeth Raike Dennis C Marshall 《Reproductive biology and endocrinology : RB&E》2005,3(1):61
Background
The use of mixed or blended protocols, that utilize both FSH and hMG, for controlled ovarian hyperstimulation is increasing in use. To reduce the number of injections a patient must administer, many physicians instruct their patients to mix their FSH and hMG together to be given as a single injection. Therefore, the goal of this study was to definitively determine if the FSH and LH bioactivities of highly purified, human-derived FSH (Bravelle(R)) and highly purified hMG (Menopur(R)) were altered by reconstituting in 0.9% saline and mixing in the same syringe. 相似文献2.
Jessica Scriver Valerie L Baker Steven L Young Barry Behr Lisa M Pastore 《Reproductive biology and endocrinology : RB&E》2010,8(1):145
Background
Serum follicle stimulating hormone (FSH) levels are used clinically to evaluate infertility, pituitary and gonadal disorders. With increased frequency of research collaborations across institutions, it is essential that inter-laboratory validation is addressed. 相似文献3.
Background
Gonadotrophins are routinely administered in assisted reproductive technology (ART) treatment protocols. Recombinant human follicle-stimulating hormone (r-hFSH; follitropin alfa) and recombinant human luteinizing hormone (r-hLH; lutropin alfa) can be administered individually or in a fixed combination. The ability to vary the FSH to LH dose ratio in a single injection without compromising the bioactivity of either gonadotrophin or generating losses of active principle is important for physicians and patients alike. 相似文献4.
John Brannian Kathleen Eyster Breanne A Mueller Mandi G Bietz Keith Hansen 《Reproductive biology and endocrinology : RB&E》2010,8(1):25
Background
The study was designed to test the hypothesis that granulosa cell (GC) gene expression response differs between recombinant FSH and human menopausal gonadotropin (hMG) stimulation regimens. 相似文献5.
Background
Testicular development is arrested in the hypogonadal (hpg) mouse due to a congenital deficiency in hypothalamic gonadotropin-releasing hormone (GnRH) synthesis. Chronic treatment of male hpg mice with estradiol induces FSH synthesis and secretion, and causes testicular maturation and qualitatively normal spermatogenesis. As estradiol negative feedback normally inhibits FSH production in the male, this study tested whether this paradoxical response to estradiol in the male hpg mouse might be due to inadequate masculinisation or incomplete defeminization in the neonatal period. Previous studies have demonstrated that treatment of hpg mice with testosterone propionate in the immediate neonatal period is necessary to allow full reproductive behaviors to be expressed following suitable endocrine stimulation at adult ages. 相似文献6.
Janet Kwee Mariet E Elting Roel Schats Joseph McDonnell Cornelis B Lambalk 《Reproductive biology and endocrinology : RB&E》2007,5(1):9-10
Background
The current study was designed to compare antral follicle count (AFC) and basal ovarian volume (BOV), the exogenous FSH ovarian reserve test (EFORT) and the clomiphene citrate challenge test (CCCT), with respect to their ability to predict poor and hyper responders. 相似文献7.
Norbert Gleicher Andrea Weghofer David H Barad 《Reproductive biology and endocrinology : RB&E》2010,8(1):140
Background
Follicle stimulating hormone (FSH) and anti-Müllerian hormone (AMH) represent the two most frequently utilized laboratory tests in determining ovarian reserve (OR). This study determined the clinical significance of their concordance and discordance in female infertility patients. 相似文献8.
Chao-Chin Hsu Hsin-Chih Kuo Chao-Tien Hsu Qing Gu 《Reproductive biology and endocrinology : RB&E》2009,7(1):107-10
Background
Follicle stimulating hormone (FSH) has been routinely used for ovulation induction. Because of rapid clearance of the hormone, FSH is commonly administered by daily intramuscular or subcutaneous injections in in-vitro fertilization (IVF). To reduce the number of visits to the clinic, an intermittent vaginal injection of rhFSH every 3 days employing the concepts of mesotherapy and uterine first-pass effect was invented and has successfully been applied in women receiving IVF treatment. This study was designed to monitor the pharmacokinetic pattern of rhFSH administered vaginally. 相似文献9.
Background
The concept of a costly immune system that must be traded off against other important physiological systems is fundamental to the burgeoning field of ecological immunity. Bumblebees have become one of the central models in this field. Although previous work has demonstrated costs of immunity in numerous life history traits, estimates of the more direct costs of bumblebee immunity have yet to be made. 相似文献10.
Nikolaos P Polyzos Human M Fatemi Apostolos Zavos Grigoris Grimbizis Dimitra Kyrou Juan-Garcia Velasco Paul Devroey Basil Tarlatzis Evangelos G Papanikolaou 《Reproductive biology and endocrinology : RB&E》2011,9(1):1-5
Background
Serum anti-Mullerian hormone (AMH) is currently considered the best marker of ovarian reserve and of ovarian responsiveness to gonadotropins in in-vitro fertilization (IVF). AMH assay, however, is not available in all IVF Units and is quite expensive, a reason that limits its use in developing countries. The aim of this study is to assess whether the "ovarian sensitivity index" precisely reflects AMH so that this index may be used as a surrogate for AMH in prediction of ovarian response during an IVF cycle.Methods
AMH serum levels were measured in 61 patients undergoing IVF with a "long" stimulation protocol including the GnRH agonist buserelin and recombinant follicle-stimulating hormone (rFSH). Patients were divided into four subgroups according to the percentile of serum AMH and their ovarian stimulation was prospectively followed. Ovarian sensitivity index (OSI) was calculated dividing the total administered FSH dose by the number of retrieved oocytes.Results
AMH and OSI show a highly significant negative correlation (r = -0.67; p = 0.0001) that is stronger than the one between AMH and the total number of retrieved oocytes and than the one between AMH and the total FSH dose.Conclusions
OSI reflects quite satisfactory the AMH level and may be proposed as a surrogate of AMH assay in predicting ovarian responsiveness to FSH in IVF. Being very easy to calculate and costless, its use could be proposed where AMH measurement is not available or in developing countries where limiting costs is of primary importance. 相似文献11.
Teresa R Petrino Gesulla Toussaint Yu-Wai P Lin 《Reproductive biology and endocrinology : RB&E》2007,5(1):21-9
Background
Activin and inhibin are glycoproteins structurally related to the transforming growth factor-beta superfamily. These peptides were first described as factors that regulate the follicle-stimulating hormone (FSH) at the pituitary level. The possible role of inhibin and activin, at the ovarian level, in mediating the stimulatory actions of a Fundulus pituitary extract (FPE) and 17alpha,20beta-dihydroprogesterone (DHP) on oocyte maturation was investigated in this study. 相似文献12.
Appropriate cut-off value for follicle-stimulating hormone in azoospermia to predict spermatogenesis
Shyh-Chyan Chen Ju-Ton Hsieh Hong-Jeng Yu Hong-Chiang Chang 《Reproductive biology and endocrinology : RB&E》2010,8(1):108
Background
This study was undertaken to determine the optimal cut-off value for FSH to predict the presence of spermatogenesis in patients with non-obstructive azoospermia. 相似文献13.
Background
Gene-based (genic) microsatellites are a useful tool for plant genetics and simple sequence repeat loci can often be found in coding regions of the genome. While EST sequencing can be used to discover genic microsatellites, direct screening of cDNA libraries for repeat motifs can save on overall sequencing costs. The objective of this research was to screen a large cDNA library from and Andean common bean genotype for six di-nucleotide and tri-nucleotide repeat motifs through a filter hybridization approach and to develop microsatellite markers from positive clones. 相似文献14.
Helen Baines Margaret O Nwagwu Graham R Hastie Roman A Wiles Terry M Mayhew Francis JP Ebling 《Reproductive biology and endocrinology : RB&E》2008,6(1):4
Background
The hypogonadal (hpg) mouse is widely used as an animal model with which to investigate the endocrine regulation of spermatogenesis. Chronic treatment of these GnRH-deficient mice with estradiol is known to induce testicular maturation and restore qualitatively normal spermatogenesis. The aim of the current studies was to investigate whether these effects of estradiol are direct effects in the testis, or indirect actions via paradoxical stimulation of FSH secretion from the pituitary gland. 相似文献15.
Elisabeth Hochschorner Maria Noring 《The International Journal of Life Cycle Assessment》2011,16(9):897-902
Purpose
The aim of this paper is to describe life cycle costing (LCC) practices in some Swedish organisations, investigate probable changes and determine whether and how environmental costs (internal and/or external) are considered in current LCC. 相似文献16.
Background
Follicle-stimulating hormone (FSH), a member of gonadotropin family, is critical for follicular maturation and ovarian steroidogenesis. Serum FSH levels are known to fluctuate during different phases of menstrual cycle in premenopausal women, and increase considerably after the menopause as a result of ovarian function cessation. There is little existing evidence to guide researchers in estimating the reliability of serum FSH measurements. The objective of this study was to assess the reliability of FSH measurement using stored sera from an ongoing prospective cohort – the NYU Women's Health Study.Methods
Sixty healthy women (16 premenopausal, 44 postmenopausal), who donated at least two blood samples at approximately 1-year intervals were studied. An immunoradiometric assay using a sandwich monoclonal antibodies technique was used to measure FSH levels in serum.Results
The reliability of a single log-transformed FSH measurement, as determined by the intraclass correlation coefficient, was 0.70 for postmenopausal women (95% confidence interval (CI), 0.55–0.82) and 0.09 for premenopausal women (95% CI, 0–0.54).Conclusions
These results suggest that a single measurement is sufficient to characterize the serum FSH level in postmenopausal women and could be a useful tool in epidemiological research. For premenopausal women, however, the reliability coefficient was low, suggesting that a single determination is insufficient to reliably estimate a woman's true average serum FSH level and repeated measurements are desirable.17.
Tsung-Hsien Lee Chung-Hsien Liu Chun-Chia Huang Kung-Chen Hsieh Pi-Mei Lin Maw-Sheng Lee 《Reproductive biology and endocrinology : RB&E》2009,7(1):100-10
Background
This study was designed to assess the capability of ovarian reserve markers, including baseline FSH levels, baseline anti-Müllerian hormone (AMH) levels, and antral follicle count (AFC), as predictors of live births during IVF cycles, especially for infertile couples with advanced maternal age and/or male factors. 相似文献18.
Vegard Eldholm Mecky Matee Sayoki GM Mfinanga Manfred Heun Ulf R Dahle 《BMC microbiology》2006,6(1):76
Background
Tanzania has a high tuberculosis incidence, and genotyping studies of Mycobacterium tuberculosis in the country are necessary in order to improve our understanding of the epidemic. Spoligotyping is a potentially powerful genotyping method due to fast generation of genotyping results, high reproducibility and low operation costs. The recently constructed SpolDB4 database and the model-based program 'spotclust' can be used to assign isolates to families, subfamilies and variants. The results of a study can thus be analyzed in a global context. 相似文献19.
20.
Jiri Moos Karel Rezabek Vanda Filova Martina Moosova Jana Pavelkova Jana Peknicova 《Reproductive biology and endocrinology : RB&E》2009,7(1):86