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1.
张晓莉  姚元庆  彭红梅  王黎娜  郭晓东  王辉 《生物磁学》2014,(6):1009-1011,1021
目的:窦卵是女性宫腔内的泡状细胞,与女性卵巢的发育及功能密切相关。本研究针对体外受精(IVF)周期中基础窦卵泡数(antral follicle count, AFC)的变化情况,探讨AFC 对卵巢反应的预测价值,为临床研究提供理论基础。方法:回顾性分析2012 年1月至2012 年12 月在我院生殖医学中心接受体外受精- 胚胎移植的157 例患者的临床资料,根据基础窦卵泡数将所选病例分为A 组(bAFC逸10)和B组(bAFC<10)。对比并分析两组研究对象的促性腺激素(Gn)的用量及使用时间、获卵数、人绒毛膜促性腺激素(HCG)注射日的血清中雌激素(E2)水平、受精率、临床妊娠率等。结果:A 组患者的Gn 用量、HCG日E2 值、获卵数及临床妊娠率均显著高于B 组,差异具有统计学意义(P〈0.05);两组患者的年龄和基础卵泡刺激素水平差异显著且具有统计学意义(P〈0.05);两组患者的不孕原因、不孕年限及助孕方式无明显差异(P〉0.05)。结论:基础窦卵泡对体外受精女性促排卵周期的卵巢反应及助孕结局具有一定的预测价值,其数量的多少可作为促排卵过程中评价卵巢反应性的参考指标,应在临床进一步推广。  相似文献   

2.
目的:基础卵泡刺激素(bFSH)可以刺激精子生成和促进卵子成熟,是人体内重要的激素之一。本研究针对体外受精(IVF)周 期bFSH 水平的变化情况,探讨bFSH对卵巢反应的预测价值,为临床研究提供理论基础。方法:回顾性分析2012 年1 月-2012 年 12 月在我院生殖医学中心接受体外受精- 胚胎移植(IVF-ET)治疗的154例患者的临床资料,根据基础卵泡刺激素水平分为A 组 (bFSH≥10 IU/L)、B 组(8≤bFSH≤10 IU/L)和C 组(bFSH<8 IU/L)。对比分析三组对象的年龄、基础窦卵泡数(bAFC)、黄体生成素 (LH)含量、FSH/LH 值、促性腺激素(Gn)的用量、使用时间、受精率及临床妊娠率等。结果:三组患者的年龄、bAFC 及FSH/LH相比 较,差异具有统计学意义(P<0.05);三组的Gn 用量和时间、获卵数及妊娠率比较,差异显著且具有统计学意义(P<0.05);三组基础 LH 值及超排卵周期受精率无显著差异(P>0.05)。结论:基础卵泡刺激素(bFSH)对体外受精女性的卵巢储备功能具有一定的预测 价值,bFSH 水平的高低可作为预测女性不孕患者超排卵周期卵巢反应性的一项重要指标,值得临床推广和应用。  相似文献   

3.
目的:基础卵泡刺激素(bFSH)可以刺激精子生成和促进卵子成熟,是人体内重要的激素之一。本研究针对体外受精(IVF)周期bFSH水平的变化情况,探讨bFSH对卵巢反应的预测价值,为临床研究提供理论基础。方法:回顾性分析2012年1月-2012年12月在我院生殖医学中心接受体外受精-胚胎移植(IVF-ET)治疗的154例患者的临床资料,根据基础卵泡刺激素水平分为A组(bFSH≥10 IU/L)、B组(8≤bFSH≤10 IU/L)和C组(bFSH8 IU/L)。对比分析三组对象的年龄、基础窦卵泡数(bAFC)、黄体生成素(LH)含量、FSH/LH值、促性腺激素(Gn)的用量、使用时间、受精率及临床妊娠率等。结果:三组患者的年龄、bAFC及FSH/LH相比较,差异具有统计学意义(P0.05);三组的Gn用量和时间、获卵数及妊娠率比较,差异显著且具有统计学意义(P0.05);三组基础LH值及超排卵周期受精率无显著差异(P0.05)。结论:基础卵泡刺激素(bFSH)对体外受精女性的卵巢储备功能具有一定的预测价值,bFSH水平的高低可作为预测女性不孕患者超排卵周期卵巢反应性的一项重要指标,值得临床推广和应用。  相似文献   

4.
目的:基础卵泡刺激素(bFsH)可以刺激精子生成和促进卵子成熟,是人体内重要的激素之一。本研究针对体外受精(IVF)周期bFSH水平的变化情况,探讨bFSH对卵巢反应的预测价值,为临床研究提供理论基础。方法:回顾性分析2012年1月-2012年12月在我院生殖医学中心接受体外受精.胚胎移植(IVF—ET)治疗的154例患者的临床资料,根据基础卵泡刺激素水平分为A组CoFSH≥10IU/L)、B组(8≤bFsH≤10IU/L)和c组(bFSH〈8IU/L)。对比分析三组对象的年龄、基础窦卵泡数(bAFC)、黄体生成素(LH)含量、FSH/LH值、促性腺激素(Gn)的用量、使用时间、受精率及临床妊娠率等。结果:三组患者的年龄、bAFC及FSH/LH相比较,差异具有统计学意义(P〈0.05);三组的Gn用量和时间、获卵数及妊娠率比较,差异显著且具有统计学意义(P〈0.05);三组基础LH值及超排卵周期受精率无显著差异(P〉0.05)。结论:基础卵泡刺激素(bFSH)对体外受精女性的卵巢储备功能具有一定的预测价值,bFSH水平的高低可作为预测女性不孕患者超排卵周期卵巢反应性的一项重要指标,值得临床推广和应用。  相似文献   

5.
目的:比较基因重组卵泡刺激素(r-FSH)及高纯度尿源性卵泡刺激素(HP-u FSH)对体外受精-胚胎移植(IVF-ET)妊娠结局的影响,结合临床表现从药学角度探讨和分析。方法:回顾分析具IVF/单精子卵细胞浆内显微注射授精(ICSI)指诊并首次接受IVF/ICSI助孕的不孕症患者235例,以给予的FSH药物种类不同分为2组:HP-u FSH组(n=135)和r-FSH组(n=100)。主要研究指标为出生率,次要研究指标为临床妊娠率,流产率及着床率。结果:HP-u FSH组外源性促性腺激素(Gn)总量和FSH量均多于r-FSH组(P0.01),获卵数和可移植胚胎数较r-FSH组少(P0.01),受精率较r-FSH组低(P0.05)。两组平均Gn刺激天数,妊娠结局及中重度卵巢过度刺激综合征(OHSS)发生率均无统计学差异(P0.05)。对患者年龄35岁和≥35岁分别进行分组发现,年龄35岁患者中的HP-u FSH组较r-FSH组平均年龄更大,不孕年限更长,基础窦卵泡数(AFC)更少(P0.01),≥35岁患者中的HP-u FSH组与r-FSH组的基本特征(年龄,不孕年限,AFC)无统计学差异(P0.05);无论年龄35岁或年龄≥35岁,HP-u FSH组的Gn量和FSH量较r-FSH组均更大,获卵数及可移植胚胎数更少(P0.01)。结论:在IVF/ICSI周期治疗中,国产HP-u FSH与r-FSH进行COS具有等同的IVF临床妊娠率及出生率。  相似文献   

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目的:比较分析拮抗剂方案与长方案对年轻卵巢低反应(POR)女性体外受精(IVF)新鲜移植周期临床妊娠结局的影响,以探讨拮抗剂方案的应用价值。方法:回顾性分析2014年1月至2017年6月在广东省妇幼保健院生殖中心行体外受精-胚胎移植(IVF-ET)治疗的204例妇女213个IVF新鲜移植周期的临床资料。按随机数字表法分为拮抗剂组83例(84治疗周期)与长方案组121例(129治疗周期),比较两组一般资料、实验室资料、促排卵资料及妊娠结局的差异。结果:拮抗剂组的窦卵泡计数(AFC)、抗苗勒氏激素(AMH)水平、促性腺激素(Gn)使用天数、Gn总量、HCG日雌二醇(E2)水平、HCG日内膜厚度、移植日内膜厚度、获卵数、成熟卵子数及正常受精数低于长方案组,基础FSH/LH、Gn启动量高于长方案组(P0.05),但两组优质胚胎数、移植胚胎数、移植囊胚比例、冷冻胚胎数、胚胎种植率及早期自然流产率比较均无统计学差异(P0.05)。拮抗剂组和长方案组的临床妊娠率较高,分别为58.14%和63.10%,但是两组临床妊娠率比较无统计学差异(P0.05)。结论:给予年轻POR患者两种方案均可获得较满意的IVF新鲜移植周期临床妊娠结局,拮抗剂方案获卵数较长方案少,但是其优势在于Gn使用量更少,使用时间更短。  相似文献   

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摘要 目的:探讨促排卵过程中添加重组人生长激素(r-hGH)对卵巢储备功能低下(DOR)患者体外授精-胚胎移植(IVF-ET)结局的影响,并分析妊娠结局的影响因素。方法:选择2021年1月至2022年1月徐州市中心医院拟接受IVF-ET治疗的DOR患者60例、徐州医科大学附属沭阳医院拟接受IVF-ET治疗的DOR患者36例,共计96例,采用随机数字表法分为两组,每组48例,对照组予以常规促排卵治疗,观察组促排卵过程中添加r-hGH治疗,比较两组促排卵、体外受精、胚胎移植以及妊娠相关指标。此外,根据妊娠结局将所有患者分成妊娠成功组和妊娠失败组,采用多因素Logistic回归分析IVF-ET结局的影响因素。结果:观察组胚胎种植率、临床妊娠率高于对照组(P<0.05);观察组与对照组注射重组人促卵泡激素(Gn)天数、Gn用量、人绒毛膜促性腺激素(HCG)日雌二醇(E2)水平、HCG日黄体生成素(LH)水平、HCG日子宫内膜厚度、获卵数、成熟卵数、受精率、卵裂率、可移植胚胎数、优质胚胎数、移植胚胎数、早期流产率比较差异无统计学意义(P>0.05)。单因素分析结果显示:妊娠失败组女方平均年龄大于妊娠成功组,基础卵泡刺激素(FSH)水平、IVF周期≥2个的患者比例高于妊娠成功组,促排卵应用了r-hGH的患者比例低于妊娠成功组,HCG日子宫内膜厚度小于妊娠成功组,基础窦卵泡数(AFC)个数、成熟卵数、优质胚胎数少于妊娠成功组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示:女方年龄≥35岁、基础FSH≥14.40 IU/L、HCG日子宫内膜厚度<10 mm、基础AFC<5.5个是DOR患者IVF-ET妊娠失败的危险因素,而促排卵应用r-hGH治疗是保护因素(P<0.05)。结论:促排卵过程中增加r-hGH治疗可提高DOR患者IVF-ET胚胎种植率、临床妊娠率。女方年龄、基础FSH和AFC、HCG日子宫内膜厚度、r-hGH治疗均与IVF-ET妊娠结局有关。  相似文献   

8.
摘要 目的:探讨早卵泡期长效长方案联合重组黄体生成素(r-LH)对卵巢高反应人群排卵和妊娠结局的影响。方法:选入2019年1月~2023年3月在我院行早卵泡期长效长方案促排卵的卵巢高反应患者150例,根据是否添加r-LH分为对照组(未添加r-LH,n=75)和观察组(添加r-LH,n=75)。比较两组的促排卵相关指标和妊娠结局。结果:观察组Gn天数、Gn总量、HCG日血清LH水平、优质胚胎率均显著高于对照组,获卵数显著少于对照组(P<0.05)。两组降调天数、Gn启动量以及HCG日E2、P水平和子宫内膜厚度、临床妊娠率、活产率、流产率比较无差异(P>0.05)。结论:卵巢高反应患者行早卵泡期长效长方案促排卵时,添加r-LH可显著增加体内LH水平,提高优质卵泡率,对妊娠结局具有一定改善作用。  相似文献   

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目的:对比分析腹腔镜囊肿剔除术与传统手术对卵巢子宫内膜异位囊肿患者卵巢储备功能及生育功能的影响。方法:选择我院诊治的卵巢子宫内膜异位囊肿患者100例,随机分为观察组与对照组,每组各50例。对照组采用传统手术治疗,即囊肿抽吸加囊壁电凝术,观察组采用腹腔镜卵巢子宫内膜异位囊肿剔除术进行治疗,两组在手术后进行促排卵治疗。观察和比较两组的窦卵泡数、血清促卵泡生成素水平、给予促性腺激素释放激素激动剂支数、给予促性腺激素释放激素激动剂天数以及HCG注射日血清雌二醇水平,并采用超声检测两组的好胚数、卵子数、冷冻数、妊娠率、移植数以及分娩率。结果:观察组的窦卵泡数以及HCG注射日血清雌二醇水平明显高于对照组(P0.05),血清促卵泡素水平以及给予促性腺激素释放激素激动剂的支数明显低于对照组(P0.05)。此外,观察组的好胚数、卵子数、冷冻数、妊娠率、移植数以及分娩率均较对照组明显升高(P0.05)。结论:相比于传统手术,腹腔镜卵巢剔除术对患者卵巢储备功能和生育功能的影响较小,安全性较高,不影响患者的再次妊娠及分娩。  相似文献   

10.
为了探讨人类辅助生殖技术中卵巢过度刺激综合征(OHSS)发生的影响因素及其防治措施,本研究选取2014年2月至2017年4月在我院行人类辅助生殖技术患者744例,观察OHSS发生情况及影响因素,采用随机数字表法将OHSS患者随机分为观察组(n=44)和对照组(n=40),观察组给予综合干预措施,对照组给予常规治疗。通过观察OHSS两组患者妊娠成功情况,本研究发现OHSS发生率为11.29%;OHSS者和非OHSS者年龄、不孕年限、不孕原因及基础E_2值比较差异无统计学意义(p0.05);OHSS者和非OHSS者促排卵方案、HCG当日E_2值和HCG当日12 mm卵泡数差异比较有统计学意义(p0.05);Logistic回归分析结果显示HCG+HMG方案、HCG当日E_2值和HCG当日12 mm卵泡数是发生OHSS的影响因素(OR=1.652, 1.842和1.891, p0.05);观察组妊娠成功率为84.09%,明显高于对照组,差异比较有统计学意义(p0.05)。本研究表明,人类辅助生殖技术中OHSS的发生受多种因素影响,采取综合干预措施可获得良好的妊娠结局。  相似文献   

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Ectogenesis, or the use of an artificial womb to allow a foetus to develop, will likely become a reality within a few decades, and could significantly affect the abortion debate. We first examine the implications for Judith Jarvis Thomson’s violinist analogy, which argues for a woman’s right to withdraw life support from the foetus and so terminate her pregnancy, even if the foetus is granted full moral status. We show that on Thomson’s reasoning, there is no right to the death of the foetus, and abortion is not permissible if ectogenesis is available, provided it is safe and inexpensive. This raises the question of whether there are persuasive reasons for the right to the death of the foetus that could be exercised in the context of ectogenesis. Eric Mathison and Jeremy Davis have examined several arguments for this right, doubting that it exists, while Joona Räsänen has recently criticized their reasoning. We respond to Räsänen’s analysis, concluding that his arguments are unsuccessful, and that there is no right to the death of the foetus in these circumstances.  相似文献   

13.
On the diversity of the Cladocera in the tropics   总被引:20,自引:13,他引:7  
The mythical concept of an impoverished tropical cladoceran fauna is refuted. On a planetary scale, around half of the cladoceran species presently known occur exclusively in the tropics-subtropics, often with considerable restriction to particular geographical subzones. On a regional (political) scale, the situation is often unclear because of the continued fragmentary nature of studies, and because political units are not a good basis for biogeographical comparisons. At the finest level of resolution (lake-perlake comparisons), there appears to be an upper limit of c. 50 cladoceran species per individual lake. No significant difference between lakes in the temperate zone and in the tropics could be established here. Daphnia is largely absent from the tropics, but is replaced by more Sidids, Moinids, and Bosminids, such that the average cladoceran community in the limnetic zone of a tropical lake is not characterized by less species but rather by lower population densities. This, in turn, is considered a consequence of higher prevalent predation levels in the tropics.  相似文献   

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Summary A tubular network was found in the terminal endings of the visual receptor cells in the human, the monkey (Macaca mulatta), the cat and the dog. These tubules are arranged in close groups in the vicinity of the synaptic lamellae and the invaginated dendrites. According to the form, diameter, density of the tubules and to the consistence of the network formed by them one can distinguish at these places an initial type (type I), a transitory (type II) and a vesicular one (type III). In the the type III branching, bizarre forms are frequent. The diameter of all the tubules reaches 500–600 Å, their density and walls being the same as in the synaptic vesicles.Similar networks also occur in the axons of the visual receptor cells of the monkey.
Zusammenfassung In den Endigungen der Photorezeptorzellen von Mensch, Affe (Macaca mulatta), Katze und Hund kommen aus Tubuli bestehende Komplexe vor. Organellenartig in geschlossenen Gruppen angeordnet, liegen sie in Nähe der synaptischen Lamellen und der invaginierten Dendriten. An diesen Stellen kann man nach Form, Durchmesser, Dichte und Konsistenz der von den Tubuli gebildeten Komplexe drei Typen unterscheiden: 1. einen initialen (Typus I), 2. einen Übergangstypus (Typus II) und 3. einen vesiculären Typus (Typus III). In letzterem kommen häufig verzweigte, bizarre Formen vor. Der Durchmesser sämtlicher Tubuli erreicht 500–600 Å. Ihre Dichte und ihre Wand gleicht denen der synaptischen Vesikel.Ähnliche Komplexe fanden wir auch in den Axonen der Photorezeptorzellen vom Affen.
  相似文献   

16.
Methods of amperometry and potentiometric titration were used to follow dark respiration (DR) and apparent photosynthesis (AP) in the fucoids Ascophyllum nodosum (L.) Le Jol, Fucus vesiculosus L., and F. serratus L. from the Barents Sea littoral by the end of the 40-day-long polar night. The macroalgae were shown to manifest species-specific low rates of photosynthesis and respiration. However, in spite of their low photosynthetic status due to the effects of subzero temperature and prolonged low or zero illumination, the macroalgae have been able to restore DR and AP to the initial level already by the day 9; the ability to restore AP depended on the level of illumination. The study of the changes in the carbonate–bicarbonate system in the light and darkness demonstrated that the macroalgae grown in darkness, in contrast to those grown in twilight, could absorb bicarbonate in darkness; however, they lost this capacity after two-day-long illumination at an irradiance of 7 mol/(m2 s). Bicarbonate uptake in darkness and the capacity to restore the systems of photosynthesis and respiration in fucoid cells are discussed in the context of algal energy metabolism under the polar night conditions.  相似文献   

17.
The voltage-gated potassium channel is currently one of the few membrane proteins where functional roles have been mapped onto specific segments of sequence. Although high-resolution structures of the transmembrane portions of three bacterial potassium channels, the tetramerization domain and the cytoplasmic ball are available, their relative spatial arrangement in mammalian channels remains a matter of ongoing debate. Cryo-electron microscopic images of the six transmembrane voltage-gated Kv channel have been reconstructed at up to 18 Å resolution, revealing that the T1 domain tetramerizes and is suspended below the transmembrane segments. However, the resolution of these images is insufficient to reveal the location of the third piece of the puzzle, the inactivating ball domain. We have used the aberrant interactions observed in a series of chimæric channels to establish that an assembled T1 domain restricts access to the cytoplasmic face of the channel, suggesting that the N-terminal ball and chain may be confined in the space between the T1 domain and the transmembrane portion of the channel.  相似文献   

18.
The retina of the vertebrate eye is metabolically active and requires nutritive support. During the last 540 million years it has evolved into forms as complicated and nutritionally demanding as those found in avian or primate eyes. Diffusion from the choroid is generally able to supply the metabolic needs of thin retinae. However, when the thickness exceeds the limits of diffusion, structures are needed to supplement the vascular supply from the choroid. These supplemental nutritive devices include the choroidal gland, the falciform process and preretinal vascular plexus of fish, the conus papillaris of lizards, the pecten oculi of birds, the intraretinal vessels of mammals and a few novel systems that remain difficult to classify. These vascular systems are among the most variable features of the vertebrate eye. Here, we review classical and recent findings regarding such retinal nutrition systems, propose a three category classification for them based on histologic origins and speculate on the evolutionary forces which drove their development.  相似文献   

19.
Summary According to light- and electron-microscopic observations the pineal organ of the 3-day-old chicken consists of a prominent end vesicle and a tapering parenchymal stalk. During this stage the pineal lumen is in open communication with the third ventricle. However, in the 40-day-old chicken, which still possesses a well-developed end vesicle, the proximal portion of the pineal stalk displays regressive changes leading to local fragmentation. At this stage the pineal stalk is reduced, and the pineal lumen is missing. In 1-year-old chickens the parenchyma of the proximal portion of the stalk is further diminished, and in 3-year-old domestic fowl is completely displaced by bundles of collagenous fibers, only some nerve fibers being present. This post-hatching pineal development may reflect the sequence of changes leading from pineal sense organs to pineal glands.This work was supported by a grant-in-aid for Scientific Research from the Ministry of Education, Science and Culture of Japan  相似文献   

20.
Summary The choriocapillaris is a fenestrated capillary bed located posterior to the retinal pigment epithelium. It serves as the main source of supply to the photoreceptors, retinal pigment epithelium, and other cells of the outer retina. The permeability of these capillaries to intravenously injected ferritin (MW — approx. 480,000; mol. diam. 11 nm) was examined in the mouse, rabbit, and guinea pig, each of which is characterized by a different type of retinal vascularization. In all three species, the bulk of the ferritin remained in the capillary lumina, where it appeared to be blocked at the level of the diaphragmed fenestrae. Some ferritin was present in endothelial cell vacuoles. The results confirm previous work on the rat choriocapillaris and indicate that the barrier function of the choriocapillary endothelium is present even among species in which the retinal circulation differs significantly.Supported by NIH grant EY03418  相似文献   

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