Structure-based design of anti-mycobacterial drug leads that target the mycolic acid transporter MmpL3

1. Download : Download high-res image (273KB)
2. Download : Download full-size image

     

Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity

1. Download : Download high-res image (120KB)
2. Download : Download full-size image

     

Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis

1. Download : Download high-res image (193KB)
2. Download : Download full-size image

     

Small,but powerful and attractive: 19F in biomolecular NMR

1. Download : Download high-res image (151KB)
2. Download : Download full-size image

     

Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development

1. Download : Download high-res image (237KB)
2. Download : Download full-size image

     

Transient non-specific DNA binding dominates the target search of bacterial DNA-binding proteins

1. Download : Download high-res image (157KB)
2. Download : Download full-size image

     

Multi-scale Predictions of Drug Resistance Epidemiology Identify Design Principles for Rational Drug Design

1. Download : Download high-res image (202KB)
2. Download : Download full-size image

     

Structural basis of γ-secretase inhibition and modulation by small molecule drugs

1. Download : Download high-res image (253KB)
2. Download : Download full-size image

     

Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing

1. Download : Download high-res image (242KB)
2. Download : Download full-size image

     

How aberrant N-glycosylation can alter protein functionality and ligand binding: An atomistic view

1. Download : Download high-res image (227KB)
2. Download : Download full-size image

     

Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies

1. Download : Download high-res image (110KB)
2. Download : Download full-size image

     

Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy

1. Download : Download high-res image (316KB)
2. Download : Download full-size image

     

Evolving cryo-EM structural approaches for GPCR drug discovery

1. Download : Download high-res image (264KB)
2. Download : Download full-size image

     

Structures of an active type III-A CRISPR effector complex

1. Download : Download high-res image (368KB)
2. Download : Download full-size image

     

Structural basis for self-cleavage prevention by tag:anti-tag pairing complementarity in type VI Cas13 CRISPR systems

1. Download : Download high-res image (268KB)
2. Download : Download full-size image

     

Pan-cancer proteogenomics connects oncogenic drivers to functional states

1. Download : Download high-res image (339KB)
2. Download : Download full-size image

     

High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis

1. Download : Download high-res image (99KB)
2. Download : Download full-size image

     

Aryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes

1. Download : Download high-res image (131KB)
2. Download : Download full-size image

     

Molecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor

1. Download : Download high-res image (237KB)
2. Download : Download full-size image

     

LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma

1. Download : Download high-res image (213KB)
2. Download : Download full-size image