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《Cell reports》2020,30(7):2284-2296.e3
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《Current biology : CB》2019,29(14):2359-2370.e5
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目的 检测接受高效抗逆转录病毒治疗(HAART)的人类免疫缺陷病毒(HIV)感染者/艾滋病(AIDS)患者血浆中白介素(IL) 35及其受体IL12rβ2、糖蛋白130(gp130)水平的动态变化及意义。 方法 选择我院2017年1月至2018年3月收治的41例HIV感染者/AIDS患者为研究对象,选择45例同期健康体检者为对照组。分别采集HIV/AIDS患者接受HAART药物0、1、6、12个月时的外周静脉血,检测血浆中的IL 35及其受体IL12rβ2、gp130水平,同时检测血浆HIV 1 RNA载量,分析IL 35与IL12rβ2、gp130、HIV 1 RNA以及IL12rβ2、gp130与HIV 1 RNA病毒载量的相关性。 结果 与对照组相比,接受HAART(0、1、6个月)时患者血浆中IL 35、IL12rβ2、gp130水平降低(均P结论 接受HAART的HIV/AIDS患者血浆IL 35及其受体IL12rβ2、gp130水平随着接受HAART时间的延长而逐渐升高,且与HIV 1 RNA载量关系密切。血浆IL 35及其受体IL12rβ2、gp130在抗HIV感染中可能发挥一定作用。 相似文献
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Pawel Drozdzal Karolina Michalska Ryszard Kierzek Lechoslaw Lomozik Mariusz Jaskolski 《Acta Crystallographica. Section D, Structural Biology》2012,68(2):169-175
The crystal structure of an RNA/DNA hybrid dodecamer, r(5′‐uaaaagaaaagg):d(5′‐CCTTTTCTTTTA), which contains three‐quarters of the polypurine tract (PPT) sequence of the HIV RNA genome is reported. The hybrid structure was determined at 1.6 Å resolution and was found to have the A‐form conformation. However, the presence of alternate conformations along the RNA template strand indicated increased flexibility of the PPT sequence. Two segments (at nucleotides 1–2 and 6–8) of the RNA chain have two conformations exhibiting differences in torsion and pseudorotation angles. For conformation I(1–2, 6–8), 25% of the RNA sugars have the C2′‐exo pucker and the rest have the expected C3′‐endo pucker. The II1–2 and II6–8 conformations of the RNA strand have one sugar with the C2′‐exo pucker. None of the ribose rings exist in the C2′‐endo form, in contrast to a previous report which postulated a C2′‐endo ribose as a key structural element of the PPT. The widths of the minor groove for conformations I(1–2, 6–8) and II(1–2, 6–8) of the RNA strand are 9.2–10.5 and 9.4–10.7 Å, respectively. Both ranges are very close to the intervals accepted for A‐form RNA duplexes. On the opposing DNA primer strand most of the sugars are C3′‐endo, except for the 3′‐terminal sugars, which are C2′‐endo (T22) or O4′‐endo (T23 and A24). The duplex includes a noncanonical u1(anti)·A24(syn) base interaction with only one hydrogen bond between the bases. This noncanonical base interaction at the 5′‐end of the template distorts the values of the helical parameters of the adjacent base pair. 相似文献
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Supinda Tatip Janet Taggart Yirong Wang Colin W. MacDiarmid David J. Eide 《Molecular microbiology》2020,113(1):285-296
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THADDEUS METZ 《Developing world bioethics》2008,8(2):89-103
I defend a certain claim about rationing in the context of HIV/AIDS, namely, the 'priority thesis' that the state of a developing country with a high rate of HIV should provide highly active anti-retroviral treatment (HAART) to those who would die without it, even if doing so would require not treating most other life-threatening diseases. More specifically, I defend the priority thesis in a negative way, by refuting two influential and important arguments against it inspired by the Kantian principle of respect for persons. The 'equality argument' more or less maintains that prioritizing treatment for HIV/AIDS would objectionably treat those who suffer from it as more important than those who do not. The 'responsibility argument' says, roughly, that to ration life-saving treatment by prioritizing those with HIV would wrongly fail to hold people responsible for their actions, since most people infected with HIV could have avoided the foreseeable harm of infection. While it appears that a Kantian must think that one of these two arguments is sound, I maintain that, in fact, respect for persons grounds neither the equality nor responsibility argument against prioritizing HAART and hence at least permits doing so. If this negative defence of the priority thesis succeeds, then conceptual space is opened up for the possibility that respect for persons requires prioritizing HAART, which argument I sketch in the conclusion as something to articulate and defend in future work. 相似文献
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Elodie Rey Michael Abrouk Gabriel Keeble‐Gagnère Miroslava Karafiátová Jan Vrána Sandrine Balzergue Ludivine Soubigou‐Taconnat Véronique Brunaud Marie‐Laure Martin‐Magniette Takashi R. Endo Jan Barto? International Wheat Genome Sequencing Consortium Rudi Appels Jaroslav Dole?el 《Plant biotechnology journal》2018,16(10):1767-1777
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Srikulnath K Uno Y Matsubara K Thongpan A Suputtitada S Apisitwanich S Nishida C Matsuda Y 《Genetics and molecular biology》2011,34(4):582-586
Chromosomal mapping of the butterfly lizards Leiolepis belliana belliana and L. boehmei was done using the 18S-28S and 5S rRNA genes and telomeric (TTAGGG)n sequences. The karyotype of L. b. belliana was 2n = 36, whereas that of L. boehmei was 2n = 34. The 18S-28S rRNA genes were located at the secondary constriction of the long arm of chromosome 1, while the 5S rRNA genes were found in the pericentromeric region of chromosome 6 in both species. Hybridization signals for the (TTAGGG)n sequence were observed at the telomeric ends of all chromosomes, as well as interstitially at the same position as the 18S-28S rRNA genes in L. boehmei. This finding suggests that in L. boehmei telomere-to-telomere fusion probably occurred between chromosome 1 and a microchromosome where the 18S-28S rRNA genes were located or, alternatively, at the secondary constriction of chromosome 1. The absence of telomeric sequence signals in chromosome 1 of L. b. belliana suggested that its chromosomes may have only a few copies of the (TTAGGG)n sequence or that there may have been a gradual loss of the repeat sequences during chromosomal evolution. 相似文献