Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease

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Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting

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Global Burden of Disease Study 2019 suggests that metabolic risk factors are the leading drivers of the burden of ischemic heart disease

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Monoallelic pathogenic ALG5 variants cause atypical polycystic kidney disease and interstitial fibrosis

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Human gut bacterial metabolism drives Th17 activation and colitis

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Monoallelic IFT140 pathogenic variants are an important cause of the autosomal dominant polycystic kidney-spectrum phenotype

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Periodontal disease is associated with increased gut colonization of pathogenic Haemophilus parainfluenzae in patients with Crohn’s disease

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Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures

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Excess neuropeptides in lung signal through endothelial cells to impair gas exchange

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A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery

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WeiTsing,a pericycle-expressed ion channel,safeguards the stele to confer clubroot resistance

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The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability

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Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult

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Propionic Acid Promotes the Virulent Phenotype of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli

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Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk

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A selective antibiotic for Lyme disease

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Structural mechanisms of GABAA receptor autoimmune encephalitis

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Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy

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Immunoglobulin A Targets a Unique Subset of the Microbiota in Inflammatory Bowel Disease

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The global burden of metabolic disease: Data from 2000 to 2019

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