Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants,including BA.4 and BA.5

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Neutralization of SARS-CoV-2 Omicron sub-lineages BA.1, BA.1.1, and BA.2

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SARS-CoV-2 Omicron sublineages exhibit distinct antibody escape patterns

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Determinants of Spike infectivity,processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2

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Antibody evasion of SARS-CoV-2 Omicron BA.1, BA.1.1, BA.2, and BA.3 sub-lineages

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Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike

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Antigenic characterization of the SARS-CoV-2 Omicron subvariant BA.2.75

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Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant

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Rapid escape of new SARS-CoV-2 Omicron variants from BA.2-directed antibody responses

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Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75

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Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants

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严重急性呼吸综合征冠状病毒2 Omicron变异株研究进展

世界卫生组织(World Health Organization, WHO)于2021年11月26日将首次在南非报告的新型冠状病毒 B．1.1.529 变异株列为受关注变种(variant of concern, VOC),并将其命名为奥密克戎(Omicron)。该变异株存在约50个突变,仅在刺突蛋白区域就有至少30个突变,远远超过其他流行株的突变位点数量。根据对突变位点的分析以及初步实验证实,该毒株可能具有极强的传染性以及免疫逃逸能力。Omicron变异株会怎样影响新冠疫情的走向引起了各国的广泛关注,本文将从Omicron变异株的基本特征、检测、致病性、传染性、免疫逃逸等方面进行综述。     

Clinical and immunological features of convalescent pediatric patients infected with the SARS-CoV-2 Omicron variant in Tianjin,China

COVID-19 has spread surprisingly fast worldwide, and new variants continue to emerge. Recently, the World Health Organization acknowledged a new mutant strain “Omicron”, with children were accounting for a growing share of COVID-19 cases compared with other mutant strains. However, the clinical and immunological characteristics of convalescent pediatric patients after Omicron infection were lacking. In this study, we comparatively analyzed the clinical data from pediatric patients with adult patients or healthy children and the effects of SARSCoV-2 vaccine on the clinical and immune characteristics in convalescent pediatric patients. Our results indicated that convalescent pediatric patients had unique clinical and immune characteristics different from those of adult patients or healthy children, and SARS-CoV-2 vaccination significantly affected on the clinical and immune characteristics and the prevention of nucleic acid re-detectable positive (RP) in convalescent patients. Our study further deepens the understanding of the impact of Omicron on the long-term health of pediatric patients and provides a valuable reference for the prevention and treatment of children infected with Omicron.     

Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1

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Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum

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Potent cross-reactive antibodies following Omicron breakthrough in vaccinees

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Clinical practice of rapid antigen tests for SARS-CoV-2 Omicron variant: A single-center study in China

Responding to the fast-spreading SARS-CoV-2 Omicron variant, to improve screening efficiency, rapid antigen tests (RATs) were first added as a supplementary detection method in China in mid-March, 2022. What and how big a role RATs should play need to be supported by clinical data. Here, RAT performance and relevant factors in comparison with nucleic acid amplification tests (NAATs) were assessed in Omicron-infected inpatients. From the NAAT results, nasopharyngeal swabs (NPs) performed better than oropharyngeal swabs (OPs). RATs tested on NAAT positive NPs performed better than those with OP-positive samples. The RAT positivity rate was strongly associated with high levels of N and OFR1ab genes, especially in NPs where patients also had significantly longer hospital stays and shorter days from symptom onset to RAT testing. Self-performed RATs had a detection accuracy that was comparable to professionally performed RATs when the subjects were well guided. The antigen negative rate of the studied patients was 100% at discharge. These findings suggest that, in addition to a supplementary detection role, RATs can be an important strategy for evaluating the disease progression of Omicron-infected inpatients. This study provides important clinical data to support better rules regarding RATs under China's COVID-19 prevention and control policy.     

mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant

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Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera

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