共查询到20条相似文献,搜索用时 31 毫秒
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EgMYB2, a new transcriptional activator from Eucalyptus xylem, regulates secondary cell wall formation and lignin biosynthesis 总被引:12,自引:0,他引:12
Goicoechea M Lacombe E Legay S Mihaljevic S Rech P Jauneau A Lapierre C Pollet B Verhaegen D Chaubet-Gigot N Grima-Pettenati J 《The Plant journal : for cell and molecular biology》2005,43(4):553-567
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Use of chromatin immunoprecipitation to clone novel E2F target promoters 总被引:20,自引:0,他引:20
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Weinmann AS Bartley SM Zhang T Zhang MQ Farnham PJ 《Molecular and cellular biology》2001,21(20):6820-6832
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Hu S Yao G Guan X Ni Z Ma W Wilson EM French FS Liu Q Zhang Y 《Molecular endocrinology (Baltimore, Md.)》2010,24(12):2392-2405
Epididymal function depends on androgen signaling through the androgen receptor (AR), although most of the direct AR target genes in epididymis remain unknown. Here we globally mapped the AR binding regions in mouse caput epididymis in which AR is highly expressed. Chromatin immunoprecipitation sequencing indicated that AR bound selectively to 19,377 DNA regions, the majority of which were intergenic and intronic. Motif analysis showed that 94% of the AR binding regions harbored consensus androgen response elements enriched with multiple binding motifs that included nuclear factor 1 and activator protein 2 sites consistent with combinatorial regulation. Unexpectedly, AR binding regions showed limited conservation across species, regardless of whether the metric for conservation was based on local sequence similarity or the presence of consensus androgen response elements. Further analysis suggested the AR target genes are involved in diverse biological themes that include lipid metabolism and sperm maturation. Potential novel mechanisms of AR regulation were revealed at individual genes such as cysteine-rich secretory protein 1. The composite studies provide new insights into AR regulation under physiological conditions and a global resource of AR binding sites in a normal androgen-responsive tissue. 相似文献
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Genome-wide analysis of hydrogen peroxide-regulated gene expression in Arabidopsis reveals a high light-induced transcriptional cluster involved in anthocyanin biosynthesis 总被引:4,自引:0,他引:4
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Vanderauwera S Zimmermann P Rombauts S Vandenabeele S Langebartels C Gruissem W Inzé D Van Breusegem F 《Plant physiology》2005,139(2):806-821