共查询到20条相似文献,搜索用时 0 毫秒
1.
2.
3.
4.
5.
We have used a monoclonal antibody to examine the distribution of Ultrabithorax (Ubx) proteins in Drosophila embryos and imaginal discs by immunofluorescence. Ubx proteins are nuclear and show a spatially restricted distribution in the nervous system, epidermis and mesoderm. Labelling extends from the first thoracic segment (T1) to the eighth abdominal segment (A8) in the midline cells, from T2 to A8 in the ventral nervous system and epidermis and from A1 to A8 in the somatic mesoderm. In the nervous systems and epidermis the patterns of labelling exhibit a repeat unit, the Ubx metamere, that is out of phase with the segmental repeat unit. At least in the epidermis this repeat unit appears to extend between anterior-posterior compartment boundaries and consists of a posterior compartment together with the succeeding anterior compartment. The most prominently labelled metamere in the nervous system and epidermis is that comprising the posterior region of T3 and the anterior region of A1. Within each metamere the nuclei are heterogeneously labelled. Clear heterogeneity of labelling is also seen amongst the nuclei of the T3 imaginal discs. 相似文献
6.
7.
8.
9.
Long range repression conferring boundaries of Ultrabithorax expression in the Drosophila embryo. 总被引:8,自引:3,他引:5
In an attempt to reconstruct the embryonic expression pattern of the homeotic gene Ultrabithorax (Ubx) by stable integration of fusion constructs, we identified three key control regions called PBX, ABX and BXD. Each of these confers an expression pattern mimicking certain aspects of Ubx expression. The PBX and ABX patterns are limited to the Ubx domain with anterior boundaries at parasegments 6 and 5. In contrast, the BXD pattern extends from head to tail. PBX or ABX expression boundaries are imposed on the BXD pattern, if PBX or ABX is linked to BXD. These boundaries, although not the PBX and ABX expression limits themselves, are dependent on Polycomb function. We conclude that PBX and ABX are recognized by repressors which act across large distances to suppress BXD activity. Stable and heritable Ubx expression boundaries are thus mediated by this process of long range repression. 相似文献
10.
11.
12.
13.
14.
15.
16.
Transcriptional repression by Myc 总被引:11,自引:0,他引:11
17.
Eriko Iwata Norihito Nakamichi Takamasa Suzuki Poyu Chen Misato Ohtani Takashi Ishida Hanako Hosoya Sabine Müller Tünde Leviczky Aladár Pettkó‐Szandtner Zsuzsanna Darula Akitoshi Iwamoto Mika Nomoto Yasuomi Tada Tetsuya Higashiyama Taku Demura John H Doonan Marie‐Theres Hauser Keiko Sugimoto Masaaki Umeda Zoltán Magyar László Bögre Masaki Ito 《The EMBO journal》2015,34(15):1992-2007
18.
19.
20.
Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins 总被引:4,自引:0,他引:4
Ichimura T Watanabe S Sakamoto Y Aoto T Fujita N Nakao M 《The Journal of biological chemistry》2005,280(14):13928-13935