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精神分裂症是一种复杂的大脑功能紊乱疾病,表现为认知、情绪、感官的失调,有研究认为遗传因素及环境因素对大脑发育成熟过程的影响与精神分裂症的发生有关[1]。最近报道发现,人内源性逆转录病毒的转录激活可能与某些精神分裂症患者的发病有关[2]。HERV的激活可能影响邻近基因的转录调控,或者以其编码的病毒蛋白,影响细胞的代谢,从而导致疾病的发生[3]。本实验采用巢式RT-PCR方法检测急性精神分裂症患者和正常人PBMCs中HERV-W env(包膜基因)的表达,探讨HERV的转录激活与精神分裂症发生的关系。1材料与方法28例急性精神分裂症患者血… 相似文献
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精神分裂症目前被认为是所有精神疾病中最有伤害性的一种慢性大脑疾病,具有严重破坏性。研究表明,全球范围内有1%~1.5%人患精神分裂症。精神分裂症主要表现为不正常的心理功能和紊乱性行为,发病主要原因与脑内结构病变和神经递质活动程度有关。精神分裂症目前被分为三大类:阴性精神分裂症,阳性精神分裂症,和认知缺失。目前对精神分裂症研究除基于神经生物学和脑科学的研究外,还从遗传学(先天)和社会环境(后天)等角度进行研究。在运用多种诊断技术诊断出精神分裂症后,对它的治疗主要采用药物疗法和心理疗法。 相似文献
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《上海生物医学工程》2012,(2):113-113
精神疾病的早期鉴别诊断具有一定难度,利用精神分裂症等精神病人大脑内某些蛋白质所发生的变化,就能像诊断糖尿病、冠心病等疾病那样,早期发现和诊断精神疾病。 相似文献
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《现代生物医学进展》2016,(22)
正近日,刊登于国际杂志Psychology Medicine上的一项研究报告中,来自加拿大罗森健康研究中心(Lawson Health Research Institute)的研究人员通过研究发现,受精神分裂症影响的大脑或会进行重组并且抵御疾病发展,该研究或可帮助科学家们理解精神分裂症发生的机制,同时为开发新型疗法治疗相关疾病提供帮助。 相似文献
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《现代生物医学进展》2008,8(4):804
美国科学家近日设计出了一种新的实验技术,能够对脑干(brainstem)区域进行高分辨率成像。脑干位于大脑最下部,脊髓顶端。它控制着维持呼吸、消化、心律、血压等必需的大脑功能,它同时还是许多脑化学物质的中转总部,一旦运转失调,就有可能导致上瘾、精神分裂症及帕金森症等精神疾病。有关专家认为此项技术为深入研究这一区域开启了方便之门。相关论文发表在2月29日的《科学》(Science)上。 相似文献
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《发现大脑》(Discovering the brain)由Sandra Ackerman著,1992年美国National Academy Press出版,180页。脑科学是生物科学的前沿阵地,也是宇宙中最为纷繁复杂的事物。疾病破坏着大脑功能,最令人痛苦不堪的有老年痴呆症、精神分裂症、享廷顿病及其它顽症。这些病魔是人类的敌人,神经科学家就是前沿阵地上的战士。该书以通俗易懂的笔调讨论了脑的物理结构以及语言、音乐欣赏功能区域;审视了电和化学信号怎样在脑中传递;探讨了视觉、听觉、思维以及注意力集中机制;叙述了学习以及记忆力持续出现;阐述了人 相似文献
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精神分裂症是一种精神障碍疾病。除了遗传因素外,一些环境因素也参与了精神分裂症的发生,肠道微生物群是近年来发现的主要影响因素之一。研究表明,精神分裂症患者肠道菌群普遍发生了紊乱,肠道菌群通过肠-脑轴影响神经功能和疾病。肠道菌群可以通过影响神经系统发育、免疫和代谢功能来诱导精神分裂症的发生,肠道菌群可能是精神分裂症防治的有效靶点,调节肠道菌群可能是防治精神分裂症的一种潜在方法。本文就精神分裂症的易感因素、肠道菌群在精神分裂症中的作用、机制以及防治策略等方面的研究进展进行综述。 相似文献
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In experiments on Black Sea skates (Raja clavata), the potential of the receptor epithelium of the ampullae of Lorenzini and spike activity of single nerve fibers connected to them were investigated during electrical and temperature stimulation. Usually the potential within the canal was between 0 and –2 mV, and the input resistance of the ampulla 250–400 k. Heating of the region of the receptor epithelium was accompanied by a negative wave of potential, an increase in input resistance, and inhibition of spike activity. With worsening of the animal's condition the transepithelial potential became positive (up to +10 mV) but the input resistance of the ampulla during stimulation with a positive current was nonlinear in some cases: a regenerative spike of positive polarity appeared in the channel. During heating, the spike response was sometimes reversed in sign. It is suggested that fluctuations of the transepithelial potential and spike responses to temperature stimulation reflect changes in the potential difference on the basal membrane of the receptor cells, which is described by a relationship of the Nernst's or Goldman's equation type.I. P. Pavlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad. I. M. Sechenov, Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences of the USSR, Leningrad. Pacific Institute of Oceanology, Far Eastern Scientific Center, Academy of Sciences of the USSR, Vladivostok. Translated from Neirofiziologiya, Vol. 12, No. 1, pp. 67–74, January–February, 1980. 相似文献
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N. P. Vesselkin Yu. V. Natochin 《Journal of Evolutionary Biochemistry and Physiology》2010,46(6):592-603
Evolution of living organisms is closely connected with evolution of structure of the system of regulations and its mechanisms.
The functional ground of regulations is chemical signalization. As early as in unicellular organisms there is a set of signal
mechanisms providing their life activity and orientation in space and time. Subsequent evolution of ways of chemical signalization
followed the way of development of delivery pathways of chemical signal and development of mechanisms of its regulation. The
mechanism of chemical regulation of the signal interaction is discussed by the example of the specialized system of transduction
of signal from neuron to neuron, of effect of hormone on the epithelial cell and modulation of this effect. These mechanisms
are considered as the most important ways of the fine and precise adaptation of chemical signalization underlying functioning
of physiological systems and organs of the living organism 相似文献