共查询到20条相似文献,搜索用时 31 毫秒
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Roth J Yam GH Fan J Hirano K Gaplovska-Kysela K Le Fourn V Guhl B Santimaria R Torossi T Ziak M Zuber C 《Histochemistry and cell biology》2008,129(2):163-177
In cells the quality of newly synthesized proteins is monitored in regard to proper folding and correct assembly in the early
secretory pathway, the cytosol and the nucleoplasm. Proteins recognized as non-native in the ER will be removed and degraded
by a process termed ERAD. ERAD of aberrant proteins is accompanied by various changes of cellular organelles and results in
protein folding diseases. This review focuses on how the immunocytochemical labeling and electron microscopic analyses have
helped to disclose the in situ subcellular distribution pattern of some of the key machinery proteins of the cellular protein
quality control, the organelle changes due to the presence of misfolded proteins, and the efficiency of synthetic chaperones
to rescue disease-causing trafficking defects of aberrant proteins. 相似文献
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Heme oxygenase: who needs it? 总被引:9,自引:0,他引:9
Galbraith R 《Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)》1999,222(3):299-305
Heme is a molecule that is synthesized by the sequential actions of eight enzymes and is ubiquitous throughout nature. For many years it has been known that heme is also catabolized to yield biliverdin (which is subsequently reduced to bilirubin), one atom of iron, and one molecule of carbon monoxide. There has been a recent explosion of interest in this degradative process that is catalyzed by the rate-limiting enzyme, heme oxygenase. In particular, there has been a special interest in the potential physiological and pathological roles that may be played by these breakdown products. This minireview will examine some of these potential functional correlates, with special emphasis on potential oxidant and antioxidant effects of the bilirubin, carbon monoxide, and iron that result from the activity of heme oxygenase. 相似文献
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Xanthe Meryn Glaw Therese M. Garrick Peter J. Terwee Jo R. Patching Helen Blake Clive Harper 《Cell and tissue banking》2009,10(3):241-246
Understanding what influences people to donate, or not donate, body organs and tissues is very important for the future of
transplant surgery and medical research (Garrick in J Clin Neurosci 13:524–528, 2006). A previous web-based motivation survey coordinated by the New South Wales Tissue Resource Centre found that most people
who participated in brain donation were young, female, educated Australians, not affiliated with any particular religion,
and with a higher prevalence of medical illness than the general Australian population. It discussed the main motivating factors
for brain donation to be “the benefits of the research to medicine and science”. This study has been replicated in a paper-based
version to capture a broader cross-section of the general population, to find out who they are and what motivates them to
donate. All consented and registered brain donors (n = 1,323) were sent a questionnaire via the post and recipients were given 3 months to complete the questionnaire and return
it in a reply paid envelope. Results were entered into the original web-based survey and analyzed using SPSS version 10. Six
hundred and fifty-eight questionnaires were returned completed, a response rate of 53%. The results show that people from
all age groups are interested in brain donation. The over 65’s are the largest of the groups (30.7%). The majority of the
participants were female (60.6%), married (49.2%) with children (65.8%), employed (52.9%) and have a tertiary education (73.3%).
They were either non-religious (48.2%) or Christian (41.6%) and were mostly Australian (65.4%). Most (81%) had pledged to
donate other organs and tissues for transplantation. The most commonly cited reasons for the donation were to benefit science
(27.6%), to benefit medicine (23.9%), a family illness (17.5%) and to benefit the community (16.6%). This study demonstrates
that people across all age groups are interested in brain donation. Recruitment of new brain donors could target the over
65 female Australians, who are not religious or Christian and who have also donated other organs and tissues for transplant
purposes. It also indicates the need to make donation for research part of the national transplant donation program. 相似文献
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Despite not being a criterion for severe malaria, thrombocytopenia is one of the most common complications of both Plasmodium vivax and Plasmodium falciparum malaria. In a systematic review of the literature, platelet counts under 150,000/mm3 ranged from 24-94% in patients with acute malaria and this frequency was not different between the two major species that affected humans. Minor bleeding is mentioned in case reports of patients with P. vivax infection and may be explained by medullary compensation with the release of mega platelets in the peripheral circulation by megakaryocytes, thus maintaining a good primary haemostasis. The speculated mechanisms leading to thrombocytopenia are: coagulation disturbances, splenomegaly, bone marrow alterations, antibody-mediated platelet destruction, oxidative stress and the role of platelets as cofactors in triggering severe malaria. Data from experimental models are presented and, despite not being rare, there is no clear recommendation on the adequate management of this haematological complication. In most cases, a conservative approach is adopted and platelet counts usually revert to normal ranges a few days after efficacious antimalarial treatment. More studies are needed to specifically clarify if thrombocytopenia is the cause or consequence of the clinical disease spectrum. 相似文献
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Monticone S Viola A Tizzani D Crudo V Burrello J Galmozzi M Veglio F Mulatero P 《Hormones et métabolisme》2012,44(3):163-169
Primary aldosteronism (PA) has a prevalence in the general hypertensive population from 5 to 10%, and is widely recognized as the most frequent form of secondary hypertension. The 2 main PA subtypes are aldosterone producing adenoma (APA) and bilateral adrenal hyperplasia (BAH) that account for 95% of all PA cases. The diagnosis of PA is a 3-step process that comprises screening, confirmatory testing, and subtype differentiation. The different categories of patients at an increased risk of PA who should thus undergo a screening test were described in the first Endocrine Society (ES) Practice Guidelines for diagnosis and treatment of PA published in 2008. These categories include patients with Joint National Committee Stage 2, Stage 3, or drug-resistant hypertension; hypertension, and spontaneous or diuretic-induced hypokalemia; hypertension with adrenal incidentaloma; hypertension and a family history of early-onset hypertension or cerebrovascular accident at a young age and all hypertensive first degree relatives of patients with PA. Recently, a growing number of studies have linked PA with the metabolic syndrome, diabetes, and obstructive sleep apnea that may be partly responsible for the higher rate of cardio and cerobrovascular accidents in PA patients. The aim of this review is to discuss, which patients should be screened for PA, focusing not only on the well-established categories of the ES Guidelines, but also on additional other group of patients with a potentially high prevalence of PA that has emerged from recent research. 相似文献
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Stevenson TR 《Plastic and reconstructive surgery》2007,120(4):1079-1080
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The oscillating activity of a single CDK-cyclin fusion protein can drive the orderly progression of yeast cells through DNA replication, mitosis and cell division. 相似文献
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Grandadam M 《Médecine sciences : M/S》2011,27(4):339-340
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