共查询到20条相似文献,搜索用时 15 毫秒
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Eukaryotes come in many shapes and sizes, yet one thing that they all seem to share is a decline in vitality and health over time--a process known as ageing. If there are conserved causes of ageing, they may be traced back to common biological structures that are inherently difficult to maintain throughout life. One such structure is chromatin, the DNA-protein complex that stabilizes the genome and dictates gene expression. Studies in the budding yeast Saccharomyces cerevisiae have pointed to chromatin reorganization as a main contributor to ageing in that species, which raises the possibility that similar processes underlie ageing in more complex organisms. 相似文献
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J G Gall 《FEBS letters》2001,498(2-3):164-167
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Concepts in nuclear architecture 总被引:14,自引:0,他引:14
Misteli T 《BioEssays : news and reviews in molecular, cellular and developmental biology》2005,27(5):477-487
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Recent advances in microscopy techniques and biophysical measurements have provided novel insight into the molecular, cellular and biophysical basis of cell adhesion. However, comparably little is known about a core element of cell-cell adhesion--the energy of adhesion at the cell-cell contact. In this review, we discuss approaches to understand the nature and regulation of adhesion energy, and propose strategies to determine adhesion energy between cells in vitro and in vivo. 相似文献
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John G. Watterson 《Molecular and cellular biochemistry》1988,79(2):101-105
The role of water in biochemical and cellular events is ignored by most workers. However, much recent research has pointed
to the importance of physical processes of the cell, which focus attention on such straight forward, elementary questions
as position and relationship in space of cell components. In this communication these questions are examined in terms of a
new model of water structure. A radically new feature of this model is that water clusters have long-term rather than flickering
existence and are as large as the macromolecular components of the cell. These properties allow the clusters and other components
to pack together spacially so giving rise to integrated, large-scale, subcellular structures. The intimate participation of
water in these structures would explain the fragility of the cytoplasmic organization. 相似文献