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TrkB在胆管癌中的表达及其临床意义 总被引:1,自引:0,他引:1
目的:研究胆管癌和正常胆管组织中TrkB蛋白的表达及其与临床病理特征的关系。方法:免疫组化检测42例胆管癌和10例正常胆管石蜡切片标本中TrkB蛋白的表达并分析其与临床病理因素的关系。结果:正常胆管组织中无TrkB蛋白的表达,胆管癌组织TrkB蛋白的表达率为69.0%(29/42)。TrkB表达与分化程度、有无淋巴结转移和远处转移有关,而与性别、年龄、肿瘤大小无关。TrkB蛋白在低分化组、有淋巴结转移组和有远处转移组中的表达率均高于高中分化组,无淋巴结转移组和无远处转移组(P<0.05)。结论:TrkB在胆管癌组织中的表达可作为预测胆管癌发生淋巴结转移和远处转移的指标。 相似文献
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目的:观察γ-synuclein(SNCG)在胆管癌和正常胆管组织中的表达,并探讨其在胆管癌发生、发展中的临床意义。方法:采用免疫组化方法检测SNCG蛋白在72例胆管癌组织及41例胆管正常组织中的表达水平,并分析其与胆管癌临床病理特征的关系。结果:SNCG蛋白在胆管癌组织中的阳性表达率为73.61%(53/72),高于其在胆管正常组织中的阳性表达率(4.88%,2/41),其差异有统计学意义(P0.01)。SNCG蛋白的表达与肿瘤的淋巴结转移相关(P0.01),但与患者的年龄、性别及肿瘤分化程度无关(P0.05)。结论:SNCG蛋白的表达与胆管癌的发生、发展正相关,并对胆管癌的浸润转移发挥重要的促进作用。对SNCG蛋白的研究将可能为胆管癌的早期诊断提供新的肿瘤标志物,并为胆管癌的预后判断和诊治提供重要理论依据。 相似文献
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VEGF-C和VEGF-D在肝内胆管癌组织中的表达与淋巴结转移的关系及临床意义 总被引:3,自引:0,他引:3
目的:探讨胆管癌患者血管内皮生长因子C和D(vascular endothelial growth factor-C and-D,VEGF-C and VEGF-D)在胆管癌组织中的表达及其与肿瘤淋巴结转移的关系。方法:应用免疫组化SABC法及Real-time PCR法检测57例胆管癌组织和正常胆管组织中VEGF-C、VEGF-D蛋白及其mRNA的表达。结果:胆管癌组织VEGF-C和VEGF-D表达明显高于正常胆管组织(P<0.01),其中淋巴结转移组VEGF-C、VEGF-D的表达与淋巴结未转移组间统计学差异显著(P<0.05)。VEGF-C和VEGF-D在胆管癌组织中的表达与淋巴结转移有关(P<0.01)。结论:胆管癌细胞非摄入性高表达的VEGF-C和VEGF-D与淋巴结转移密切相关,可作为评估胆管癌患者预后的重要参考指标。 相似文献
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目的:观察胆管癌组织及血清中诱导受体3(decoy receptor 3,DcR3)蛋白的表达及其临床价值。方法:采用免疫组化S-P法检测45例胆管癌、15例癌旁胆管正常组织中DcR3蛋白的表达,ELISA法检测31例胆管癌及18例胆道良性疾病患者和28例正常人外周血清中DcR3的水平。结果:45例胆管癌组织中DcR3阳性表达29例,阳性率为64.4%,胆管正常组织中无阳性表达。DcR3的表达与肿瘤临床分期、肿瘤浸润和转移有关(P<0.05)。胆管癌患者及胆管良性疾病患者血清DcR3水平分别为152.2535.94 pg/ml,98.35 14.27 pg/ml,均高于正常人。胆管癌患者与胆道良性疾病患者血清DcR3水平相比差异有显著性(P<0.01)。结论:DcR3在胆管癌组织中表达增高。DcR3的表达与胆管癌的发生、发展以及转移有关,可成为治疗胆管癌的一个新靶点。血清DcR3的检测对胆管癌的诊断有一定的临床价值。 相似文献
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目的:探讨肿瘤转移抑制基因KAI1/CD82在胆管癌组织中的表达情况及临床病理意义。方法:应用免疫组织化学技术检测48例胆管癌组织及8例正常胆管组织中的KAI1/CD82蛋白表达。结果:KAI1/CD82蛋白在胆管癌组织中阳性表达率31.3%,明显低于正常胆管组织(87.5%,P<0.01)。KAI1/CD82蛋白的表达与肿瘤分化程度、转移相关(P<0.05),而与胆管癌患者年龄、性别、肿瘤部位和病理类型无关。结论:KAI1/CD82蛋白低表达可能参与了胆管癌的发生、发展,并对肿瘤转移的判断有一定指导意义。 相似文献
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目的:观察胆管癌组织及血清中诱导受体3(decoy receptor 3,DcR3)蛋白的表达及其临床价值。方法:采用免疫组化S-P法检测45例胆管癌、15例癌旁胆管正常组织中DcR3蛋白的表达,ELISA法检测31例胆管癌及18例胆道良性疾病患者和28例正常人外周血清中DcR3的水平。结果:45例胆管癌组织中DcR3阳性表达29例,阳性率为64.4%,胆管正常组织中无阳性表达。DcR3的表达与肿瘤临床分期、肿瘤浸润和转移有关(P〈0.05)。胆管癌患者及胆管良性疾病患者血清DcR3水平分别为152.2535.94 pg/ml,98.35 14.27 pg/ml,均高于正常人。胆管癌患者与胆道良性疾病患者血清DcR3水平相比差异有显著性(P〈0.01)。结论:DcR3在胆管癌组织中表达增高。DcR3的表达与胆管癌的发生、发展以及转移有关,可成为治疗胆管癌的一个新靶点。血清DcR3的检测对胆管癌的诊断有一定的临床价值。 相似文献
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目的:探讨胆管癌患者血管内皮生长因子C和D(vascular endothelial growth factor-Cand.D,VEGF.CandVEGF.D)在胆管癌组织中的表达及其与肿瘤淋巴结转移的关系。方法:应用免疫组化SABC法及Real-timePCR法检测57例胆管癌组织和正常胆管组织中VEGF-C、vEGF-D蛋白及其mRNA的表达。结果:胆管癌组织VEGF—C和VEGF.D表达明显高于正常胆管组织(P〈0.叭),其中淋巴结转移组VEGF-C、VEGF—D的表达与淋巴结未转移组间统计学差异显著(P〈0.05)。VEGF-C和VEGF-D在胆管癌组织中的表达与淋巴结转移有关(P〈0.01)。结论:胆管癌细胞非摄入性高表达的VEGF.C和VEGF.D与淋巴结转移密切相关,可作为评估胆管癌患者预后的重要参考指标。 相似文献
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研究表明趋化因子及其受体在胚胎发育、干细胞迁移以及各种免疫反应中发挥重要作用,是许多生理及病理过程中细胞运动的重要因素。趋化因子受体CXCR4是一个由352个氨基酸构成的、7次跨膜的G蛋白偶联受体。趋化因子CXCL12为其特异性受体。研究发现,CXCR4/CXCL12在多种肿瘤中都有表达,在肿瘤的生长、血管生成、转移等方面发挥着重要作用。与正常组织相比,肿瘤组织及转移灶CXCR4高表达。因此,对CXCR4/CXCL12轴在肿瘤病生理中的作用机制进行进一步研究,很可能为肿瘤的治疗及对肿瘤转移的预防提供一个新的思路。我们现在就对其在肿瘤病生理中的作用做一综述。 相似文献
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CXCL12是趋化因子家族成员之一,是能够特异性结合其受体CXCR4发挥趋化性作用的细胞因子。最初,CXCL12及CXCR4被发现于炎症细胞,参与机体炎症、免疫等病理反应。接下来的几年中发现,它在机体发育、成熟过程中也有重要作用。如今,大量研究表明它与肿瘤的生长、侵袭及转移密切相关。据报道,在乳腺癌、肺癌、卵巢癌等二十余种肿瘤组织中发现CXCL12及CXCR4的表达,其中也包括中枢系统肿瘤-胶质瘤。CXCL12/CXCR4参与胶质瘤生长过程的多个步骤,包括肿瘤增殖、侵袭、转移等。有实验指出,转移灶的CXCR4表达水平较原发灶高,CXCR4有可能成为抑制胶质瘤生长、转移的重要靶目标。 相似文献
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Although the importance of the endosperm as a food store inmany angiosperm seeds is well known, its significance duringearly embryogenesis has been neglected. In many interspecifichybrids, and in some other situations, embryos do not developfully and abort. It has often been stated that this is causedby the endosperm failing to conduct sufficient nutrients tothe embryo, but seldom has it been suggested that the endospermactively controls most of the early stages of morphogenesisof the embryo. Information gleaned from a broad survey of theliterature, combined with additional evidence presented here,obtained fromSolanum incanumand interspecific hybrids, indicatethat the endosperm is dynamic and very active in regulatingearly embryo development. This requires highly integrated geneticcontrol of rapidly changing metabolism in the endosperm. Ininterspecific hybrids, lack of coordination may cause unbalancedproduction of growth regulating substances by the endospermand hence abortion of the embryo, or even unregulated productionof nucleases and proteases resulting firstly in autolysis ofthe endosperm and then digestion of the embryo. The endospermmay thus serve to detect inappropriate hybridization of speciesor ploidy levels and so prevent waste of resources by producingseeds that would result in sterile hybrids or unthrifty subsequentgenerations. This discriminatory function of the endosperm hasdiminished during evolution and domestication of the crop plantSolanummelongenaL.Copyright 1998 Annals of Botany Company Solanum, embryo morphogenesis, endosperm, hybrid, seed development. 相似文献
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Michele Rivkin-Flsh 《Medical anthropology quarterly》2000,14(1):119-120
Pragmatic Women and Body Politics. Margaret Lock and Patricia A. Kaufert. eds. Cambridge, UK: Cambridge University Press, 1998. xii +364 pp.
Maternities and Modernities: Colonial and Postcolonial Experiences in Asia and the Pacific. Kalpana Ram and Margaret Jolly. eds. Cambridge, UK: Cambridge University Press, 1998. xiv. 305 pp. 相似文献
Maternities and Modernities: Colonial and Postcolonial Experiences in Asia and the Pacific. Kalpana Ram and Margaret Jolly. eds. Cambridge, UK: Cambridge University Press, 1998. xiv. 305 pp. 相似文献
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Höpfl G Ogunshola O Gassmann M 《American journal of physiology. Regulatory, integrative and comparative physiology》2004,286(4):R608-R623
For most organisms oxygen is essential fo life. When oxygen levels drop below those required to maintain the minimum physiological oxygen requirement of an organism or tissue it is termed hypoxia. To counter act possible deleterious effects of such a state, an immediate molecular response is initiated causing adaptation responses aimed at cell survival. This response is mediated by the hypoxia-inducible factor-1 (HIF-1), which is a heterodimer consisting of an alpha- and a beta-subunit. HIF-1 alpha protein is stabilized under hypoxic conditions and therefore confers selectivity to this response. Hypoxia is characteristic of tumors, mainly because of impaired blood supply resulting from abnormal growth. Over the past few years enormous progress has been made in the attempt to understand how the activation of the physiological response to hypoxia influences neoplastic growth. In this review some aspects of HIF-1 pathway activation in tumors and the consequences for pathophysiology and treatment of neoplasia are discussed. 相似文献
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Studies of human constitution and mental features are traditionally among the main concepts of anthropological research. In
this research, we attempted to discover connections between morphological and constitutional features and self-esteem in children
and adolescents. Such a connection was discovered in some studied age groups. The obtained results could serve as a basis
for further studies in this field. 相似文献