A Quantitative Approach for Ranking Human Health Risks from Pesticides in Irish Groundwater

This study aims to quantitatively assess the risk of pesticides (used in Irish agriculture) and their degradation products to groundwater and human health. This assessment uses a human health Monte-Carlo risk-based approach that includes the leached quantity combined with an exposure estimate and the No Observed Adverse Effect Level (NOAEL) as a toxicity ranking endpoint, resulting in a chemical intake toxicity ratio statistic (R) for each pesticide. A total of 34 active substances and their metabolites registered and used in the agricultural field were evaluated. MCPA obtained the highest rank (i.e., in order of decreasing human health risk), followed by desethly-terbuthylazine and deethylatrazine (with risk ratio values of 1.1 × 10^?5, 9.5 × 10^?6, and 5.8 × 10^?6, respectively). A sensitivity analysis revealed that the soil organic carbon content and soil sorption coefficient were the most important parameters that affected model predictions (correlation coefficient of –0.60 and –0.58, respectively), highlighting the importance of soil and pesticide properties in influencing risk estimates. The analysis highlights the importance of taking a risk-based approach when assessing pesticide risk. The model can help to prioritize pesticides, with potentially negative human health effects, for monitoring programs as opposed to traditional approaches based on pesticide leaching potential.     

A Relative Risk Ranking of Selected Substances on Canada's National Pollutant Release Inventory

The National Pollutant Release Inventory (NPRI) provides pollutant release and transfer data from point sources to various media in the Canadian environment. While the inventory serves as Canada's community right-to-know program, the growing number of listed substances and reporting facilities makes it exceedingly difficult for the public to discern which substances are of greatest concern in their respective communities. A chemical's impact is best characterized when its environmental release data are combined with its toxicity and environmental fate properties. Presently, the NPRI does not provide a synthesis of this critical information and there is a need to provide more context with NPRI data to increase its usability. To help deliver this context, a relative risk ranking was compiled for a subset of NPRI substances using a modified Chemical Hazard and Evaluation Management Strategies (CHEMS-1) model. The model combines toxicity, chemical fate properties, and NPRI release data to yield a risk score for each substance. The resulting risk scores are ranked accordingly to provide a priority ranking of the substances. In addition to contextualizing the NPRI release data with hazard information, the ranking can also help set priorities for future risk assessment and evaluation by the Canadian government and scientific community. Limitations included the reliance on modelled data and default values to fill data gaps and uncertain reliability in reported NPRI data. In spite of its limitations, the CHEMS-1 model is a useful tool for prioritizing NPRI substances.     

Evaluation of Ecotoxicological Field Studies for Authorization of Plant Protection Products in Europe

An increasing number of ecotoxicological field studies are being submitted in the European Union procedure for authorization of pesticides. Although there is some guidance on how these studies can be used for risk assessment, not all aspects of field tests are covered and the guidance differs per type of test and per non-target group. To facilitate a more uniform approach by the regulatory authorities in the EU, a basic scheme is proposed with qualitative tools to: (i) assess the scientific reliability of individual field tests, and (ii) to assess the usefulness of field tests for regulatory risk assessment of the pesticide under registration. In this way, the treatment, evaluation, and the mutual comparability of field data for regulatory purposes is harmonized. It thereby provides a more consistent foundation for further risk assessment.     

Groundwater Vulnerability Assessment of Plant Protection Products: A Review

Plant protection products (PPPs) pose a serious dilemma; although their application contributes to the fight against poverty and diseases, at the same time these agrochemicals represent a significant public health threat. As part of Ireland's commitment to the Water Framework Directive (WFD), the country's groundwater sources and resources have to be properly monitored and specific standards in groundwater quality need to be met. Vulnerability assessment is a methodology that evaluates the likelihood of an adverse event occurring and this information can be useful for pollution prevention and decision-making purposes. The objective of this article is to review and compare the most important vulnerability assessment methods and tools that have been used in catchment/regional scale studies. While the approach used is largely dependent on available data, user requirements, and local conditions, the evaluation showed that the COP and PI index-based methods and the MACRO and PRZM process-based methods represent the most advanced tools currently available for large-scale applications. Also discussed is the importance of statistical methods for uncertainty analysis and their usefulness in reducing the data requirements of the index and process-based methods.     

Pesticide Risk Perceptions,Knowledge, and Attitudes of Operators,Workers, and Residents: A Review of the Literature

The literature on the risk perceptions, knowledge levels, and attitudes of operators, workers, and residents in relation to non-dietary exposure to agricultural pesticides is reviewed. No literature was identified in relation to bystander exposure. Research has primarily been conducted on participants in developing countries and migrant workers in the United States. For operators and workers, illiteracy, poverty, and a perception that exposure to pesticides is an inevitable part of their work results in limited adoption of safety precautions while using and storing pesticides. As a result, risk communication activities aimed at operator and workers need to take account of the wider socioeconomic and cultural conditions in which workers and operators are working and living. There is less research focused on residents’ and bystanders’ perceptions, attitudes, and behaviors. The lack of European data in general, and residents’ and bystanders’ data in particular, represents a knowledge gap that is pertinent to emerging EU legislation requiring residents’ and bystanders’ inclusion in pesticide risk assessment. This review provides a comprehensive overview that can assist policy-makers, and risk communicators in the development of targeted training and awareness-raising material for operators, workers, bystanders, and residents. Areas for future research are suggested.     

基于多目标评价方法的乳腺癌易感基因排序及其网络表达研究

目的利用已有的研究结果和数据,采用多目标评价方法建立乳腺癌易感基因评价模型,对与已知乳腺癌基因关系密切的其它基因进行分析和排序,并给出结果的网络表达模式。方法通过分析已有的文献,并利用有关的基因数据库和已有文献中的数据,提炼出乳腺癌易感基因的多目标评价体系,构建基于加权和法的乳腺癌易感基因评价模型,并利用Cytoscape软件进行评价结果计算和评价结果的网络模式表达。结果利用多目标模型所得到的评价结果,与已有的研究结果一致。其中,乳腺癌易感基因TopBP1排名第二,已知乳腺癌候选易感基因HMMR排名第六。结论文章提出的多目标评价模型能够准确评价被选基因与乳腺癌易感性之间的关系,所提出的评价方法与相关软件结合使用,将成为癌症易感基因研究方面有效的分析方法和途径。     

Development of a Relative Ranking Risk Index for Risk Assessment in the Transportation of Liquefied Petroleum Gas in Mexico City's Metropolitan Area

The development of a relative ranking methodology created specifically for the assessment of the risk due transportation of Liquefied Petroleum Gas (LPG) in Mexico City is reported. Mexico City has a number of conditions that present specific challenges: Large population, varied geography, large consumption of LPG, and all sorts of vehicles, including those for LPG. Given Mexico's status as “emerging economy,” it is reasonable to assume that the main causes that promote accidents during transportation of LPG are quite different from those in developed countries. This issue was corroborated through information from official sources and from news media. Due to the lack of official data, a systematic collection of information on the media was performed. A relative ranking methodology was developed based on a systematic study to elucidate the main causes of accidents in Mexico and on the results derived from the integrated database from official data and the media. The weighting that made up the Risk Index for Transportation of LPG is based on the same database. A classification guide was created in order to harmonize criteria in the assessment of the parameters of the proposed risk index.     

Disability Measurement for Lymphatic Filariasis: A Review of Generic Tools Used within Morbidity Management Programs

Lymphatic filariasis (LF)-related disability affects 40 million people globally, making LF the leading cause of physical disability in the world. Despite this, there is limited research into how the impacts of LF-related disability are best measured. This article identifies the tools currently being used to measure LF-related disability and reviews their applicability against the known impacts of LF. The findings from the review show that the generic disability tools currently used by LF programs fail to measure the majority of known impacts of LF-related disability. The findings from the review support the development of an LF-specific disability measurement tool and raise doubt about the suitability of generic disability tools to assess disability related to neglected tropical diseases (NTDs) globally.     

Ranked Set Sampling: Ranking Error Models and Estimation of Visual Judgment Error Variance

Ranked set sampling where sampling is based on visual judgment of the differences between the sizes of pairs of units or on a concomitant variable is reviewed. An alternative model for judgment ranking based on ratios of sizes of pairs of units is presented. Computation of the variance of a visual ranked set sampling estimator of the mean of a distribution is enabled via maximum likelihood estimation of the visual judgment error variance. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)     

Application of a Multi-Criteria Decision-Making Approach for Ranking Environmental Risks Caused by Petrochemical Industries: A Case Study of a Sodium Carbonate Production Unit

The occurrence of accidents in petrochemical industries that cause environmental catastrophes has persuaded experts to use risk-oriented approaches. The approach is to rank the key elements of risk assessment by which the priority of each risk is specified compared to the other ones. The present study was performed to test the applicability of a multi-criteria decision-making approach for prioritizing environmental risks of a petrochemical complex in southwestern Iran. Accordingly, all risky activities of the Sodium Carbonate Production Unit (SCPU) were identified initially. Afterward, the relevant environmental components affected by the risky activities were specified. According to the specification, the most significant risks were shortlisted using experts’ judgment based on three criteria: “impact intensity,” “occurrence probability,” and the “extent of contamination dispersion in the environment.” The shortlisted environmental risks were then prioritized by the Method “Elimination et Choice Translating Reality (Elimination and Choice Expressing Reality)” abbreviated as ELECTRE. Based on the obtained results, “decreased air quality” and “manpower health threatening” are the top-priority risks while “poor quality of groundwater” was identified as the least priority risk. In a general conclusion, a multi-criteria decision-making approach is quite useful for assessing environmental risks of petrochemical industries.     

中国植物源杀虫剂的研制与应用

我国植物资源极其丰富,而且应用植物杀虫历史悠久。近年来我国植物源杀虫剂研究进展迅速,获得了一批重要成果,并在某些方面接近或达到国际先进水平。本文简要综述我国植物源杀虫剂的研究现状,介绍了其杀虫活性物质的类型、有效成分、防治对象、杀虫机理及开发前景。从而为研究植物源杀虫剂奠定了基础     

A Methodology to Assess the Amounts of Pesticidal Mercury Used Historically in New Jersey

A methodology using existing, accessible public information is presented for the estimation of amounts of mercury that may have been applied to soils historically on agricultural land in the U.S. Estimations based on national agricultural consumption data reported by the Bureau of Mines can be apportioned further to the state and county level. For comparison, estimates using crop recommendations are presented, which can be considered to provide an upper-bound estimate of amounts potentially used on individual farms. In New Jersey, approximately 318,000?lb of mercury as an active ingredient could have been applied on approximately 150,000 acres of cropland and golf courses in the period 1921 to 1990. Based on crop recommendations, as much as 600,000 to over 1,000,000?lb of mercury could have been applied.     

A Regional Multiple Stressor Risk Assessment of the Codorus Creek Watershed Applying the Relative Risk Model

The relative risk model (RRM) used in Port Valdez, AK, and in Oregon's Willamette/McKenzie Watershed was applied to the Codorus Creek Watershed in south central Pennsylvania. The assessment evaluated the relative risk model for its applicability for ranking ecological risks within the Codorus Creek Watershed. The Codorus Creek Watershed approach included ranking stressors and habitats for regions within the watershed. Geographical Information Systems were vital in compiling and comparing stressor and habitat spatial data from regions in the watershed. The risk of ecological impacts to degrade assessment endpoints were calculated and ranked by quantitatively determining the interactions of the stressors and habitats as defined in the conceptual site model. Uncertainty assessment was conducted and the impact upon the relative ranks and risk conclusions evaluated. To determine regional risks, risk management information was gathered identifying areas to be protected, areas of high stress, and areas where additional information is needed. The results supported the applicability of the RRM and suggested areas and stressors for restoration efforts in the Codorus Creek Watershed. Two critical sets of conclusions were drawn from the assessment. First, in the Codorus Creek Watershed, the most significant stressor is agriculture land use, the most significantly impacted endpoint is water quality, and the most vulnerable habitats are those for macroinvertebrates and warm-water fish. Second, this risk assessment demonstrates the feasibility of using the RRM for assessing risk from multiple stressors on habitats with multiple assessment endpoints in an eastern watershed.     

Involvement of Proteolytic Enzymes and Their Inhibitors in Plant Protection (Review)

The literature data on possible ways of involvement of proteolytic enzymes and their inhibitors in protection of plants from pests and disease are analyzed. Certain practical applications of natural protease inhibitors to plant protection are discussed.     

A Brief Review of Software Tools for Pangenomics

Since the proposal for pangenomic study, there have been a dozen software tools actively in use for pangenomic analysis. By the end of 2014, Panseq and the pan-genomes analysis pipeline(PGAP) ranked as the top two most popular packages according to cumulative citations of peerreviewed scientific publications. The functions of the software packages and tools, albeit variable among them, include categorizing orthologous genes, calculating pangenomic profiles, integrating gene annotations, and constructing phylogenies. As epigenomic elements are being gradually revealed in prokaryotes, it is expected that pangenomic databases and toolkits have to be extended to handle information of detailed functional annotations for genes and non-protein-coding sequences including non-coding RNAs, insertion elements, and conserved structural elements. To develop better bioinformatic tools, user feedback and integration of novel features are both of essence.     

A comparison of macrophyte indices in headwaters of rivers in Flanders (Belgium)

Macrophytes were monitored in 48 headwater rivers in Flanders (Belgium). Only 26 sites had macrophyte vegetation, which was used to calculate five different indices and scores. These indices originated from UK, France, Czech Republic and Germany. Macrophytes were significantly correlated with a number of habitat variables, such as transect size, river width, slope, Huet zonation, distance to source, shadowing and average depth. For the substrate there were significant negative correlations with the fine particle sizes and a positive correlation with the coarse particles. A multivariate analysis of the macrophytes in these headwaters showed three groupings, essentially separated on basis of water hardness and pH.     

Merits and Pitfalls of Currently Used Diagnostic Tools in Mycetoma

Treatment of mycetoma depends on the causative organism and since many organisms, both actinomycetes (actinomycetoma) and fungi (eumycetoma), are capable of producing mycetoma, an accurate diagnosis is crucial. Currently, multiple diagnostic tools are used to determine the extent of infections and to identify the causative agents of mycetoma. These include various imaging, cytological, histopathological, serological, and culture techniques; phenotypic characterisation; and molecular diagnostics. In this review, we summarize these techniques and identify their merits and pitfalls in the identification of the causative agents of mycetoma and the extent of the disease. We also emphasize the fact that there is no ideal diagnostic tool available to identify the causative agents and that future research should focus on the development of new and reliable diagnostic tools.     

石鼓书院植物景观资源评价与保护

石鼓书院共有植物29科31属41种,主要植物景观类型5种.文章对评价指标进行量化,建立了植物景观评价指标体系,采用植物景观综合评价指数法和AHP法对石鼓书院槙物景观进行评价与分析.认为其植物景观资源整体水平偏低,植物景现质量为IIl级;对石鼓书院的植物景观恢复和保护提出了可行性建议.