共查询到20条相似文献,搜索用时 15 毫秒
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Numerous examples exist of how disrupting the actions of physiological regulators of blood cell development yields hematologic malignancies. The master regulator of hematopoietic stem/progenitor cells GATA-2 was cloned almost 20 years ago, and elegant genetic analyses demonstrated its essential function to promote hematopoiesis. While certain GATA-2 target genes are implicated in leukemogenesis, only recently have definitive insights emerged linking GATA-2 to human hematologic pathophysiologies. These pathophysiologies include myelodysplastic syndrome, acute myeloid leukemia and an immunodeficiency syndrome with complex phenotypes including leukemia. As GATA-2 has a pivotal role in the etiology of human cancer, it is instructive to consider mechanisms underlying normal GATA factor function/regulation and how dissecting such mechanisms may reveal unique opportunities for thwarting GATA-2-dependent processes in a therapeutic context. This article highlights GATA factor mechanistic principles, with a heavy emphasis on GATA-1 and GATA-2 functions in the hematopoietic system, and new links between GATA-2 dysregulation and human pathophysiologies. 相似文献
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Yokomizo T Takahashi S Mochizuki N Kuroha T Ema M Wakamatsu A Shimizu R Ohneda O Osato M Okada H Komori T Ogawa M Nishikawa S Ito Y Yamamoto M 《The EMBO journal》2007,26(1):184-196
Hemangioblasts are thought to be one of the sources of hematopoietic progenitors, yet little is known about their localization and fate in the mouse embryo. We show here that a subset of cells co-expressing the hematopoietic marker GATA-1 and the endothelial marker VE-cadherin localize on the yolk sac blood islands at embryonic day 7.5. Clonal analysis demonstrated that GATA-1(+) cells isolated from E7.0-7.5 embryos include a common precursor for hematopoietic and endothelial cells. Moreover, this precursor possesses primitive and definitive hematopoietic bipotential. By using a transgenic complementation rescue approach, GATA-1(+) cell-derived progenitors were selectively restored in Runx1-deficient mice. In the rescued mice, definitive erythropoiesis was recovered but the rescued progenitors did not display multilineage hematopoiesis or intra-aortic hematopoietic clusters. These results provide evidence of the presence of GATA-1(+) hemangioblastic cells in the extra-embryonic region and also their functional contribution to hematopoiesis in the embryo. 相似文献
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Primitive erythropoiesis in the Xenopus embryo: the synergistic role of LMO-2, SCL and GATA-binding proteins 总被引:11,自引:0,他引:11
Mead PE Deconinck AE Huber TL Orkin SH Zon LI 《Development (Cambridge, England)》2001,128(12):2301-2308
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Autophagy driven by a master regulator of hematopoiesis 总被引:1,自引:0,他引:1
Kang YA Sanalkumar R O'Geen H Linnemann AK Chang CJ Bouhassira EE Farnham PJ Keles S Bresnick EH 《Molecular and cellular biology》2012,32(1):226-239
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GATA1 in normal and malignant hematopoiesis 总被引:1,自引:0,他引:1
Crispino JD 《Seminars in cell & developmental biology》2005,16(1):137-147