共查询到20条相似文献,搜索用时 0 毫秒
1.
Allan Berlind 《Comparative biochemistry and physiology. Toxicology & pharmacology : CBP》2001,130(1):85-95
Haloperidol (a dopamine D2 blocker in vertebrates) and phentolamine (an α-adrenergic blocker) alter the pattern of bursting by the isolated cardiac ganglion of the lobster when perfused at concentrations of 10?6–10?5 mol/l. Both drugs decrease the frequency of bursting and increase burst duration. They are most effective in slowing the ganglion when applied selectively to the anterior ganglionic trunk, the same region of the ganglion where dopamine (DA) and 5-hydroxytryptamine (5HT) are most effective in speeding up bursting. When exogenous monoamine transmitters are applied in the presence of 3×10?6 mol/l haloperidol, the effect of 5HT, but not of DA, is significantly reduced. At the same concentration, phentolamine does not suppress the actions of DA, 5HT or noradrenaline (NA). Both haloperidol and phentolamine significantly alter the properties of endogenous burst-organizing potentials (driver potentials) generated by motorneurons in the ganglion. It is possible that the effects of these drugs on bursting reflect alteration of endogenous electrical properties of the constituent neurons, rather than receptor antagonism. 相似文献
2.
3.
4.
Kenro Tazaki 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1993,172(3):369-387
Activity patterns of the constituent neurons of the posterior cardiac plate-pyloric system in the stomatogastric ganglion of the mantis shrimp Squilla oratoria were studied by recording spontaneous burst discharges intracellularly from neuronal somata. These neurons were identified electrophysiologically, and synaptic connections among them were qualitatively analysed. The posterior cardiac plate constrictor, pyloric constrictor, pyloric dilator and ventricular dilator motoneurons, and the pyloric interneuron were involved in the posterior cardiac plate-pyloric system. All the cell types could produce slow burst-forming potentials which led to repetitive spike discharges. These neurons generated sequentially patterned outputs. Most commonly, the posterior cardiac plate neuron activity was followed by the activity of pyloric constrictor neurons, and then by the activity of pyloric dilator/pyloric interneuron, and ventricular dilator neurons. The motoneurons and interneuron in the posterior cardiac plate-pyloric system were connected to each other either by electrical or by inhibitory chemical synapses, and thus constructed the neural circuit characterized by a wiring diagram which was structurally similar to the pyloric circuit of decapods. The circuitry in the stomatogastric ganglion was strongly conserved during evolution between stomatopods and decapods, despite significant changes in the peripheral structure of the foregut. There were more electrical synapses in stomatopods, and more reciprocal inhibitory synapses in decapods.Abbreviations EJP
excitatory junctional potential
- IPSP
inhibitory postsynaptic potential
- CoG
commissural ganglion
- CPG
central pattern generator
- ion
inferior oesophageal nerve
- OG
oesophageal ganglion
- pcp
posterior cardiac plate
- son
superior oesophageal nerve
- STG
stomatogastric ganglion
- stn
stomatogastric nerve
- PY
pyloric constrictor
- PD
pyloric dilator
- VD
ventricular dilator
- AB
pyloric interneuron
- lvn
lateral ventricular nerves
- tcpm
transverse cardiac plate muscle 相似文献
5.
6.
Corinne I. Rodgers John D. LaBrie R. Meldrum Robertson 《Journal of insect physiology》2009,55(7):599-3216
Stress-induced arrest of ventilatory motor pattern generation is tightly correlated with an abrupt increase in extracellular potassium concentration ([K+]o) within the metathoracic neuropil of the locust, Locusta migratoria. Na+/K+-ATPase inhibition with ouabain elicits repetitive surges of [K+]o that coincide with arrest and recovery of motor activity. Here we show that ouabain induces repetitive [K+]o events in a concentration-dependent manner. 10−5 M, 10−4 M, and 10−3 M ouabain was bath-applied in semi-intact locust preparations. 10−4 M and 10−3 M ouabain reliably induced repetitive [K+]o events whereas 10−5 M ouabain had no significant effect. In comparison to 10−4 M ouabain, 10−3 M ouabain increased the number and hastened the time to onset of repetitive [K+]o waves, prolonged [K+]o event duration, increased resting [K+]o, and diminished the absolute value of [K+]o waves. Recovery of motor patterning following [K+]o events was less likely in 10−3 M ouabain. In addition, we show that K+ channel inhibition using TEA suppressed the onset and decreased the amplitude of ouabain-induced repetitive [K+]o waves. Our results demonstrate that ventilatory circuit function in the locust CNS is dependent on the balance between mechanisms of [K+] accumulation and [K+] clearance. We suggest that with an imbalance in favour of accumulation the system tends towards a bistable state with transitions mediated by positive feedback involving voltage-dependent K+ channels. 相似文献
7.
Zhang H Zhao Y Lei M Dobrzynski H Liu JH Holden AV Boyett MR 《American journal of physiology. Heart and circulatory physiology》2007,292(1):H165-H174
Voltage-dependent sodium (Na(+)) channels are heterogeneously distributed through the pacemaker of the heart, the sinoatrial node (SA node). The measured sodium channel current (i(Na)) density is higher in the periphery but low or zero in the center of the SA node. The functional roles of i(Na) in initiation and conduction of cardiac pacemaker activity remain uncertain. We evaluated the functional roles of i(Na) by computer modeling. A gradient model of the intact SA node and atrium of the rabbit heart was developed that incorporates both heterogeneities of the SA node electrophysiology and histological structure. Our computations show that a large i(Na) in the periphery helps the SA node to drive the atrial muscle. Removal i(Na) from the SA node slows down the pacemaking rate and increases the sinoatrial node-atrium conduction time. In some cases, reduction of the SA node i(Na) results in impairment of impulse initiation and conduction that leads to the SA node-atrium conduction exit block. Decrease in active SA node cell population has similar effects. Combined actions of reduced cell population and removal of i(Na) from the SA node have greater impacts on weakening the ability of the SA node to pace and drive the atrium. 相似文献
8.
9.
10.
E M Deuchar 《Developmental biology》1970,22(2):185-199
11.
Species richness in ground water is still largely underestimated, and this situation stems from two different impediments:
the Linnaean (i.e. the taxonomic) and the Wallacean (i.e. the biogeographical) shortfalls. Within this fragmented frame of
knowledge of subterranean biodiversity, this review was aimed at (i) assessing species richness in ground water at different
spatial scales, and its contribution to overall freshwater species richness at the continental scale; (ii) analysing the contribution
of historical and ecological determinants in shaping spatial patterns of stygobiotic species richness across multiple spatial
scales; (iii) analysing the role of β-diversity in shaping patterns of species richness at each scale analysed. From data
of the present study, a nested hierarchy of environmental factors appeared to determine stygobiotic species richness. At the
broad European scale, historical factors were the major determinants in explaining species richness patterns in ground water.
In particular, Quaternary glaciations have strongly affected stygobiotic species richness, leading to a marked latitudinal
gradient across Europe, whereas little effects were observed in surface fresh water. Most surface-dwelling fauna is of recent
origin, and colonized this realm by means of post-glacial dispersal. Historical factors seemed to have also operated at the
smaller stygoregional and regional scales, where different karstic and porous aquifers showed different values of species
richness. Species richness at the small, local scale was more difficult to be explained, because the analyses revealed that
point-diversity in ground water was rather low, and at increasing values of regional species richness, reached a plateau.
This observation supports the coarse-grained role of truncated food webs and oligotrophy, potentially reflected in competition
for food resources among co-occurring species, in shaping groundwater species diversity at the local scale. Alpha-diversity
resulted decoupled from γ-diversity, suggesting that β-diversity accounted for the highest values of total species richness
at the spatial scales analysed. 相似文献
12.
Distribution of crustacean diapause: micro- and macroevolutionary pattern and process 总被引:4,自引:1,他引:4
Theoretical predictions for the relationships between duration of dormancy, reproductive life span, and dispersal ability developed for plants in temporally varying environments are applied here to crustaceans. Mathematical models suggest that diapause duration should negatively covary with adult life span, and that both diapause and life span should negatively covary with dispersal ability. A survey of 167 crustacean species from 20 orders and three classes confirms that species with prolonged diapause have short adult life spans and those with long adult lives either have diapause lasting less than a year, or do not diapause at all. Prolonged diapause is more common among small or inland water crustaceans than it is among large or marine species, whereas large or marine species have significantly longer adult life spans on average than do those that are small or from inland waters. A greater fraction of species in the Branchiopoda exhibit prolonged diapause than do members of the Maxillopoda which, in turn, are more likely to exhibit prolonged diapause than are the Malacostraca. A greater fraction of malacostracan species have adult life spans exceeding one year than do species in either the Branchiopoda or the Maxillopoda. Cladistic analysis shows that phylogenetic constraint is likely to be at least in part responsible for the expression of diapause among the Crustacea. We conclude that both natural selection and macroevolutionary pattern have influenced the distribution of diapause among modern crustaceans. 相似文献
13.
Dopamine (DA) causes a dose-dependent increase in the frequency of motor neuron bursts [virtual ventilation (fR)] produced by deafferented crab ventilatory pattern generators (CPGv). Domperidone, a D2-specific DA antagonist, by itself reversibly depresses fR and also blocks the stimulatory effects of DA. Serotonin (5HT) has no direct effects on this CPGv. Nicotine also causes dramatic dose-dependent increases in the frequency of motor bursts from the CPGv. The action is triphasic, beginning with an initial reversal of burst pattern typical of reversed-mode ventilation, followed by a 2- to 3-min period of depression and then a long period of elevated burst rate. Acetylcholine chloride (ACh) alone is ineffective, but in the presence of eserine is moderately stimulatory. The inhibitory effects of nicotine are only partially blocked by curare. The excitatory action of nicotine is blocked by prior perfusion of domperidone, but not by SKF-83566.HCl, a D1-specific DA antagonist. SKF-83566 had no effects on the ongoing pattern of firing. These observations support the hypothesis that dopaminergic pathways are involved in the maintenance of the CPGv rhythm and that the acceleratory effects of nicotine may involve release of DA either directly or via stimulation of atypical ACh receptors at intraganglionic sites. 相似文献
14.
Three distinct clusters of crustacean cardioactive-peptide-immunoreactive neurones occur in the terminal abdominal ganglion of the crayfish species Orconectes limosus, Astacus leptodactylus, Astacus astacus and Procambarus clarkii, as revealed by immunocytochemistry of whole-mount preparations and sections. They exhibit similar topology and projection patterns in all four studied species. An anterior ventral lateral and a posterior lateral cluster contain one small, strongly stained perikaryon and two large, less intensely stained perikarya, each showing contralateral projections. A posterior medial lateral cluster of up to six cells also contains these two types of perikarya. Whereas the small type perikarya belong to putative interneurones, the large type perikarya give rise to extensive neurohaemal plexuses in perineural sheaths of the third roots of the fifth abdominal ganglia, the connectives, the dorsal telson nerves, the ganglion itself, its roots and arteriolar supply. Thin fibres from these plexuses reach newly discovered putative neurohaemal areas around the hindgut and anus via the intestinal and the anal nerves, and directly innervate the phasic telson musculature. A comparison with earlier investigations of motoneurones and segmentation indicates that these three cell groups containing putative neurosecretory neurones may be members of at least three neuromeres in this ganglion. Crustacean cardioactive peptide released from these neurones may participate in the neurohumoral and modulatory control of different neuronal and muscle targets, thereby exceeding its previously established hindgut and heart excitatory effects.Abbreviations
AG
abdominal ganglion
-
adpl
arteria dorsalis pleica
-
Ala
arreria lateralis abdominalis
-
Asub
arteria subneuralis
-
CCAP
crustacean cardioactive peptide
-
CNS
central nervous system
-
IR
immunoreactive
-
LG
lateral giant axon
-
LTr
lateral tract
-
MDT
medial dorsal tract
-
MG
medial giant axon
-
M Tr
medial tract
-
mcan
musculus compressor ani
-
mfltp
museulus flexor telsonos posterior
-
nan
nervus ani (AG6 N5)
-
nant
nervus anterior (AG6 N1, N2)
-
nia
nervus intestinal anterior
-
nin
nervus intestinalis (AG6 N7)
-
nip
nervus intestinalis posterior
-
nteld
nervus telsonos dorsalis (AG6 N6)
-
nielv
nervus telsonos ventralis (AG6 N4)
-
nur
nervus uropedalis (AG6 N3)
-
nven
nervus ventralis (AG5 N3)
-
PIR
peri-intestinal ring
-
PTF
posterior telson flexor
-
VLT
ventral lateral tract
-
VMT
ventral medial tract
-
VNC
ventral nerve cord
-
VIF
ventral telson flexor
-
AVLC, PLC, PMLC
anterior ventral lateral, posterior lateral, posterior medial lateral CCAP-immunoreactive cell cluster
-
A6AVC, A7AVC
anterior ventral commissures
-
A7DCI
dorsal commissure I
-
A7PVC
posterior ventral commissure
-
A7SCII
sensory commissure II
-
A7VCII, A7VCIII
ventral commissures II and III of the sixth (A6) and seventh (A7) abdominal neuromer 相似文献
15.
16.
17.
Modulation of neuronal impulse pattern is examined by means of a simplified Hodgkin-Huxley type computer model which refers to experimental recordings of cold receptor discharges. This model essentially consists of two potentially oscillating subsystems: a spike generator and a subthreshold oscillator. With addition of noise the model successfully mimics the major types of experimentally recorded impulse patterns and thereby elucidate different resonance behaviors. (1) There is a range of rhythmic spiking or bursting where the spike generator is strongly coupled to the subthreshold oscillator. (2) There is a pacemaker activity of more complex interactions where the spike generator has overtaken part of the control. (3) There is a situation where the two subsystems are decoupled and only resonate with the help of noise. 相似文献
18.
19.
Kenro Tazaki Kohji Sakai 《Comparative biochemistry and physiology. Part A, Molecular & integrative physiology》1998,120(4):579-586
Neurotransmitters of motor neurons in the foregut muscles of an isopod Ligia exotica were identified by recording changes in membrane potential to exogenously applied glutamate and acetylcholine. The effects of antagonists, tubocurare and joro spider toxin, on excitatory junctional potentials evoked by nerve stimulation and by iontophoretic application of glutamate and acetylcholine provided additional evidence for identification. The junctional receptors were desensitized by putative neurotransmitters. Glutamate is a candidate as an excitatory neurotransmitter at the neuromuscular junctions in intrinsic muscles of the gastric mill and pylorus, and acetylcholine is a candidate in the extrinsic muscles of the gastric mill and cardiopyloric valve. 相似文献
20.
Milsom WK Reid SG Meier JT Kinkead R 《Comparative biochemistry and physiology. Part A, Molecular & integrative physiology》1999,124(3):253-264
There are two components to breathing pattern generation the production of the pattern of neural discharge associated with individual breaths, and the pattern in which breaths are produced to effect ventilation. Bullfrogs typically breathe with randomly distributed breaths. When respiratory drive is elevated, breathing becomes more regular and often episodic. Studies on in vitro brainstem-spinal cord preparations of the adult bullfrog and in situ preparations of decerebrate, paralyzed, unidirectionally ventilated animals suggest that output from the central rhythm generator in frogs is conditional on receiving some input and that a host of central inputs remain even in the most reduced preparations. There appear to be descending inputs from sites in the dorsal brainstem just caudal to the optic chiasma that cluster breaths into episodes, a strong excitatory input caudal to this site but rostral to the origin of the Vth cranial nerve and, possibly, segmental rhythm generators throughout the medulla that are normally entrained to produce the normal breathing pattern. The data also suggest that the shape of the discharge pattern (augmenting, decrementing) and timing of outputs (alternating vs synchronous) associated with motor outflow during each breath are also dependent on the interconnections between these various sites. 相似文献