共查询到20条相似文献,搜索用时 46 毫秒
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Shilpi Paul Alex Kuo Thomas Schalch Hannes Vogel Leemor Joshua-Tor W. Richard McCombie Or Gozani Molly Hammell Alea A. Mills 《Cell reports》2013,3(1):92-102
Highlights? Tandem PHDs of Chd5 facilitate binding to unmodified H3 ? Chd5 preferentially binds loci lacking H3K4me3 ? Chd5 mediates expression of cancer genes ? The Chd5-H3 interaction is crucial for efficient tumor suppression 相似文献
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Vérane Sommermeyer Claire Béneut Emmanuel Chaplais Maria Elisabetta Serrentino Valérie Borde 《Molecular cell》2013,49(1):43-54
Highlights? Spp1 and histone H3K4 residue are important for meiotic DSB formation ? Spp1 physically interacts with the DSB protein Mer2 ? Spp1 in meiosis is not with RNA Pol II, but on chromosome axes in DSB-rich domains ? Spp1’s PHD finger tethers H3K4me3 regions to chromosome axes for DSB formation 相似文献
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Jia-Hui Ng Vibhor Kumar Masafumi Muratani Petra Kraus Jia-Chi Yeo Lai-Ping Yaw Kun Xue Thomas Lufkin Shyam Prabhakar Huck-Hui Ng 《Developmental cell》2013,24(3):324-333
Highlights? Modified small-scale ChIP-seq method applicable to small number of cells ? Genome-wide maps of H3K4me3, H3K27me3, H3K27ac, and H2BK20ac of germ cells in vivo ? Identification of active and inactive regulatory elements in germ cells in vivo ? Germ cell H3K27me3 regions are enriched for retrotransposon repeats 相似文献
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Jaehoon Kim Jung-Ae Kim Robert K. McGinty Uyen T.T. Nguyen Tom W. Muir C. David Allis Robert G. Roeder 《Molecular cell》2013,49(6):1121-1133
Highlights? H2B ubiquitylation directly stimulates H3K4 methylation by the yeast Set1 complex ? Swd2 is not directly required for the H3K4 methylation activity of the yeast Set1 complex ? The Set1 n-SET domain plays a critical role in H2Bub-dependent H3K4 methylation ? Spp1 is conditionally involved in n-SET- and H2Bub-dependent H3K4 methylation 相似文献
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Maria A. Hahn Runxiang Qiu Xiwei Wu Arthur X. Li Heying Zhang Jun Wang Jonathan Jui Seung-Gi Jin Yong Jiang Gerd P. Pfeifer Qiang Lu 《Cell reports》2013,3(2):291-300
Highlights? 5hmC levels increase in neuronal function-related genes during neurogenesis ? 5hmC gain is accompanied by H3K27me3 loss at promoters and gene bodies ? Gain of 5hmC is not associated with substantial DNA demethylation ? Polycomb and Tet protein together promote proper progression of neurogenesis 相似文献
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María J. Barrero Borja Sese Bernd Kuebler Josipa Bilic Stephanie Boue Mercè Martí Juan Carlos Izpisua Belmonte 《Cell reports》2013,3(4):1005-1011
Highlights? Macrohistone variants are regulated during reprogramming and differentiation ? The levels of macrohistone variants modulate the efficiency of reprogramming ? MacroH2A.1 occupies pluripotency and differentiation genes in keratinocytes ? MacroH2A.1 occupancy prevents the gain of H3K4me2 during reprogramming 相似文献
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Highlights? ESCs with short telomeres do not stably differentiate and can resume proliferation ? Critically short telomeres impair Nanog regulation during ESC differentiation ? Short telomeres elicit genome-wide DNA hypomethylation and altered H3K27me3 levels ? Impaired DNA methylation and differentiation are rescued by Dnmt3b or telomere elongation 相似文献
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Monica Rolando Serena Sanulli Christophe Rusniok Laura Gomez-Valero Clement Bertholet Tobias Sahr Raphael Margueron Carmen Buchrieser 《Cell host & microbe》2013,13(4):395-405
Highlights? Upon infection, L. pneumophila secretes RomA, a SET domain-containing methyltransferase ? RomA triggers H3K14 trimethylation, causing a switch from gene activation to repression ? ChIP-seq identified 4,870 H3K14 methylated promoter regions, including innate immune genes ? RomA SET domain is required for efficient intracellular replication of L. pneumophila 相似文献
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Lipeng Wu Shirley Y. Lee Bo Zhou Uyen T.T. Nguyen Tom W. Muir Song Tan Yali Dou 《Molecular cell》2013,49(6):1108-1120
Highlights? ASH2L WH motif is important for trans-regulation of H3 K4 methylation by H2Bub ? Ub stimulates MLL activity in trans, in contrast to DOT1L regulation by H2Bub ? H2Bub enhances MLL, but not MLL3, methyltransferase activity ? H2Aub directly represses MLL methyltransferase activity 相似文献
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Rui Fang Fei Chen Zhenghong Dong Di Hu Andrew J. Barbera Erin A. Clark Jian Fang Ying Yang Pinchao Mei Michael Rutenberg Ze Li Ying Zhang Youwei Xu Huirong Yang Ping Wang Matthew D. Simon Qiongjie Zhou Jing Li Yujiang Geno Shi 《Molecular cell》2013,49(3):558-570
Highlights? Identifying NPAC as a novel LSD2 cofactor stimulating H3K4 demethylation ? Structure determination of LSD2 alone or in complex with NPAC and histone H3 peptide ? Defining the key NPAC residues essential for its intrinsic LSD2 cofactor activity ? Establishing a molecular model for how a cofactor regulates histone demethylation 相似文献
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Repression of the Long Noncoding RNA-LET by Histone Deacetylase 3 Contributes to Hypoxia-Mediated Metastasis 总被引:1,自引:0,他引:1
Fu Yang Xi-song Huo Sheng-xian Yuan Ling Zhang Wei-ping Zhou Fang Wang Shu-han Sun 《Molecular cell》2013,49(6):1083-1096
Highlights? There is low expression of lncRNA-LET in various tumor tissues ? Hypoxia-induced low expression of lncRNA-LET occurred through histone deacetylase 3 ? The lncRNA-LET is bound to NF90, which increases NF90 degradation by the proteasome ? Low lncRNA-LET expression contributes to hypoxia-induced cell invasion 相似文献
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Florian MC Dörr K Niebel A Daria D Schrezenmeier H Rojewski M Filippi MD Hasenberg A Gunzer M Scharffetter-Kochanek K Zheng Y Geiger H 《Cell Stem Cell》2012,10(5):520-530
Highlights? Constitutively increasing Cdc42 activity causes aging of young HSCs ? Elevated Cdc42 activity correlates with a loss of cell polarity in aged HSCs ? Inhibition of Cdc42 activity rejuvenates aged LT-HSC function ? Cdc42 inhibition restores the level and spatial distribution of AcH4K16 相似文献
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Matthew A. McBrian Iman Saramipoor Behbahan Roberto Ferrari Trent Su Ta-Wei Huang Kunwu Li Candice S. Hong Heather R. Christofk Maria Vogelauer David B. Seligson Siavash K. Kurdistani 《Molecular cell》2013,49(2):310-321
Highlights? Global levels of histone acetylation change in response to pHi alterations ? Histone deacetylation and acetate transport through H+-coupled MCTs regulates pHi ? Proliferation of T cells results in increases in pHi and global histone acetylation ? HDAC and MCT inhibitors decrease pHi 相似文献
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Sen GL Boxer LD Webster DE Bussat RT Qu K Zarnegar BJ Johnston D Siprashvili Z Khavari PA 《Developmental cell》2012,22(3):669-677
Highlights? Induction of ZNF750 expression is necessary for terminal epidermal differentiation ? The C2H2 domain of ZNF750 is necessary for its prodifferentiation function ? p63 is necessary for the induction of ZNF750 expression during differentiation ? ZNF750 activates the expression of KLF4 to drive differentiation gene expression 相似文献
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Renato Ostuni Viviana Piccolo Iros Barozzi Sara Polletti Alberto Termanini Silvia Bonifacio Alessia Curina Elena Prosperini Serena Ghisletti Gioacchino Natoli 《Cell》2013,152(1-2):157-171
Highlights? Latent enhancers are regulatory elements unmarked and unbound in differentiated cells ? Stimulus-dependent TFs co-opt lineage-determining TFs to activate latent enhancers ? Latent enhancers may confer short-term memory of environmental exposure ? Environmental stimulation qualitatively alters the pre-existing enhancer repertoire 相似文献