Dynamin 2 Potentiates Invasive Migration of Pancreatic Tumor Cells through Stabilization of the Rac1 GEF Vav1

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Highlights? Dyn2 promotes lamellipodia formation and pancreatic tumor cell migration ? Direct binding between Dyn2 and Vav1 promotes Rac1 activation and migration ? Dyn2 binding protects Vav1 from degradation by the lysosome ? Vav1 is targeted for degradation through an interaction with Hsc70     

Pou5f1-Dependent EGF Expression Controls E-Cadherin Endocytosis,Cell Adhesion,and Zebrafish Epiboly Movements

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Highlights? Pou5f1 regulates EGF expression during oogenesis ? EGFR signaling controls E-cadherin trafficking at blastula and gastrula stages ? E-cadherin subcellular trafficking controls adhesion and cell migration ? Dynamics of E-cadherin adhesion is essential for effective cell migration     

Loss of Dickkopf-1 Restores Neurogenesis in Old Age and Counteracts Cognitive Decline

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Highlights? Dkk1 antagonizes Wnt activity in NPCs ? Loss of Dkk1 increases NPCs, neuronal progeny, and neuronal activity in DG ? Loss of Dkk1 has beneficial effects on affective behavior in the tail suspension test ? Loss of Dkk1 in NPCs restores DG neurogenesis and cognition in old age     

Peripheral Nerve-Derived CXCL12 and VEGF-A Regulate the Patterning of Arterial Vessel Branching in Developing Limb Skin

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Highlights? Cxcr4 is expressed by a subset of endothelial cells in the capillary network ? Genetic inactivation of Cxcl12-Cxcr4 signaling perturbs nerve-vessel alignment ? Cxcl12 controls endothelial migration, whereas VEGF directs arterial differentiation     

p58IPK-Mediated Attenuation of the Proapoptotic PERK-CHOP Pathway Allows Malignant Progression upon Low Glucose

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Highlights? Transformation-associated glucose shortage triggers ER stress ? The ER stress acts as barrier to malignancy by triggering UPR-dependent apoptosis ? p58^IPK expression removes the UPR barrier by attenuating its PERK-CHOP branch ? This adaptive mechanism enables implementation of UPR cytoprotective features     

Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis

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Highlights? E. histolytica expresses a convergently evolved RGS-RhoGEF protein ? EhRGS-RhoGEF possesses a conventional nine-helix RGS domain ? Activated EhRGS-RhoGEF induces S2 cell spreading through Rac1/2 ? EhRGS-RhoGEF modulates amoebic migration and host cell killing     

Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis

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Highlights? A metabolic behavior revealing a key homeostatic role for the invertebrate intestine ? Enteric neurons couple reproductive state with intestinal physiology ? An insulinergic brain-gut neuronal circuit adjusts feeding to nutritional conditions ? A vasopressin-like system of central neurons is essential for water homeostasis     

MicroRNA-9 Coordinates Proliferation and Migration of Human Embryonic Stem Cell-Derived Neural Progenitors

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Highlights? miR-9 is expressed in hESC-derived early hNPCs and their progeny ? Loss of miR-9 inhibits early hNPC proliferation and delays maturation ? miR-9 knockdown promotes hNPC migration in vitro and in vivo ? Stathmin is a target of miR-9 and mediates its effects in early hNPCs     

A novel aux/IAA28 signaling cascade activates GATA23-dependent specification of lateral root founder cell identity

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Highlights? GATA23 is involved in lateral root founder cell specification ? A coordinated migration of pericycle nuclei precedes the first asymmetric division ? An Aux/IAA28-dependent auxin signaling cascade controls GATA23 expression     

Structural Mechanism of CCM3 Heterodimerization with GCKIII Kinases

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Highlights? Crystal structure of CCM3-MST4 heterodimeric complex ? Structural mechanism driving CCM3-GCKIII heterodimerization ? Conformational changes required for CCM3-GCKIII heterodimerization ? Synergistic effects of CCM3-MST4 complex on cell proliferation and migration     

Calponin 2 Acts As an Effector of Noncanonical Wnt-Mediated Cell Polarization during Neural Crest Cell Migration

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Highlights? Cnn2 is expressed in NCCs and required for their migration in frogs and chicks ? Cnn2 is inactivated by noncanonical Wnt signaling ? Loss of Cnn2 causes a switch from cortical actin to central stress fibers ? Cnn2 polarizes the actin cytoskeleton downstream of PCP     

Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions

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Highlights? Myosin-IXA, an actin-motor- and RhoGAP-protein, is required for collective migration ? Myosin-IXA is required for radial actin bundle assembly at nascent cell-cell contacts ? The localization of myosin-IXA to actin bundles is dependent on its motor domain ? Myosin-IXA RhoGAP domain locally inhibits Rho stabilizing nascent cell-cell contacts     

Syndecan-4 Phosphorylation Is a Control Point for Integrin Recycling

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Highlights? c-Src phosphorylates syndecan-4 in response to extracellular stimuli ? Syndecan-4 phosphorylation and engagement regulate Arf6 activity ? Syndecan-4-mediated Arf6 activity regulates differential integrin recycling ? Syndecan-4-mediated integrin recycling controls FA dynamics and cell migration     

ESCs Require PRC2 to Direct the Successful Reprogramming of Differentiated Cells toward Pluripotency

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Highlights? Mouse pluripotent cells reprogram human B cells in heterokaryons ? ESCs lacking PRC1 or PRC2 cannot successfully reprogram ? Failure of PRC1/2-deficient ESCs to reprogram is functionally dominant ? PRC1/2 play a critical role in the chromatin reorganization required for reprogramming     

Asymmetric mode of Ca²⁺-S100A4 interaction with nonmuscle myosin IIA generates nanomolar affinity required for filament remodeling

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Highlights? S100A4 dimer binds single-myosin IIA molecule in an asymmetrical mode ? Synergy between Ca-dependent sites in S100A4 leads to high-affinity interaction ? Electron microscopy shows that two S100A4 dimers bind to the myosin coiled coil ? S100A4 has direct effect on formation of stress fibers and cell migration     

CRL1-FBXO11 Promotes Cdt2 Ubiquitylation and Degradation and Regulates Pr-Set7/Set8-Mediated Cellular Migration

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Highlights? Cullin 4A promotes the autoubiquitylation of Cdt2, a substrate adaptor of CRL4^Cdt2 ? CRL1^FBXO11 also ubiquitylates and promotes the degradation of Cdt2 ? FBXO11 degrades Cdt2 to stabilize Set8 and regulate the response to TGF-β ? FBXO11 is similarly required to stabilize Set8 and promote cell migration     

Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish

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Highlights? Neutrophil motility in live zebrafish requires PI(3)K activity at the leading edge ? Localized photo-activation of Rac can to direct migration in vivo ? Rac activation rescues protrusion but not polarization in PI(3)K-inhibited cells ? Separable two-tier regulation of F-actin dynamics and protrusion by PI(3)K     

Evolutionary Shift from Fighting to Foraging in Blind Cavefish through Changes in the Serotonin Network

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Highlights? Astyanax cavefish have lost aggressive behavior during adaptation to life in the dark ? Astyanax raphe serotonergic neurons control social behavior ? Astyanax hypothalamic serotonergic neurons control homeostatic functions ? The development of a neuronal network links to the behaviors it controls     

Role of the Mad2 Dimerization Interface in the Spindle Assembly Checkpoint Independent of Kinetochores

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Highlights? Mad2 overexpression activates the SAC independently from Mad1 in budding yeast ? Mad2 dimerization surface is required for the SAC independently from Mad1 ? Mad2 dimerization downstream of kinetochores is negligible for the SAC ? Mad2 dimerization surface interacts with Mad3 and is required for MCC stability