共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
Highlights? Involvement of formin mDia3 in stable kinetochore microtubule attachment ? The actin activity of mDia3 is not necessary for metaphase chromosome alignment ? EB1-binding by mDia3 contributes to position chromosomes at the metaphase plate ? Aurora B phosphorylates mDia3 to regulate its microtubule activity 相似文献
3.
Highlights? Gene expression noise is an efficient means to probe dose responses ? Variability in MYC reveals biphasic E2f1 dose response ? Modeling predicts serum attenuates E2F repression by MYC ? Biphasic expression underlies discrimination of aberrant levels of growth signaling 相似文献
4.
Daniela G Seidler 《Current opinion in structural biology》2012,22(5):578-582
Highlights? Mutation in the decorin gene causes opacity. ? Gene involved in the synthesis of CS/DS of decorin leads to defects in dermal collagen fibrils. ? Genes involved in the sulfation of CS/DS also lead to altered dermal collagen fibrils. ? Lack of decorin and changes in CS/DS structures might lead to an altered cell signaling. 相似文献
5.
Highlights? The crystal structure of 12-lipoxygenase was solved at high resolution ? The position of an inhibitor identified the substrate binding/active site ? A channel providing access for oxygen to the active site was also discovered ? The structure accounts for virtually all features of catalysis and inhibition 相似文献
6.
Highlights? Discovery that Rspo3 binds syndecan 4 ? Rspo3/Sdc4 induce Wnt/PCP signaling via clathrin-mediated endocytosis ? Rspo3/PCP signaling is essential for gastrulation and cartilage morphogenesis 相似文献
7.
Meng Zhang Liang Dong Zhubing Shi Shi Jiao Zhen Zhang Wenqing Zhang Guoguang Liu Cuicui Chen Miao Feng Qian Hao Wenjia Wang Mengxin Yin Yun Zhao Lei Zhang Zhaocai Zhou 《Structure (London, England : 1993)》2013,21(4):680-688
Highlights? Crystal structure of CCM3-MST4 heterodimeric complex ? Structural mechanism driving CCM3-GCKIII heterodimerization ? Conformational changes required for CCM3-GCKIII heterodimerization ? Synergistic effects of CCM3-MST4 complex on cell proliferation and migration 相似文献
8.
Murphy GS Mills JL Miley MJ Machius M Szyperski T Kuhlman B 《Structure (London, England : 1993)》2012,20(6):1086-1096
Highlights? Flexible backbone design has been used to mutate every position in a protein core ? The redesign is hyperthermostable (melting temperature >140°C) ? An NMR structure and an X-ray structure closely match the design model ? Designed backbone perturbations were accurately recapitulated 相似文献
9.
Bénédicte F. Py Mi-Sung Kim Helin Vakifahmetoglu-Norberg Junying Yuan 《Molecular cell》2013,49(2):331-338
Highlights? Inhibition of deubiquitination blocks inflammasome activation ? Inhibition of deubiquitination induces NLRP3 polyubiquitination ? Deubiquitination of NLRP3 regulates the activation of inflammasome ? The deubiquitinating enzyme BRCC3 deubiquitinates the LRR domain of NLRP3 相似文献
10.
Highlights? The 3D structure of PKCι in complex with a peptide from Par-3 is determined ? PKCι does not need phosphorylation of Thr402 in its activation loop for its activity ? aPKCs do not need a priming kinase for their activations ? The PKCι/Par-3 structure reveals a unique substrate recognition patterns for aPKCs 相似文献
11.
Highlights? Smad-interacting protein 1 (SIP1) regulates hESC differentiation ? SIP1 upregulation promotes neuroectodermal differentiation ? SIP1 inhibits mesendodermal and endodermal differentiation ? SMAD2/3 and NANOG/OCT4/SOX2 cooperatively regulate SIP1 expression 相似文献
12.
Minmin Liu Kayo Imamura April M. Averill Susan S. Wallace Sylvie Doublié 《Structure (London, England : 1993)》2013,21(2):247-256
Highlights? Neil3 is an Fpg/Nei DNA glycosylase of the base excision repair pathway ? Neil3 excises a broad spectrum of base lesions, with a marked preference for ssDNA ? We report a crystal structure of Neil3 DNA glycosylase ? The structure provides valuable insights into Neil3′s unusual substrate specificity 相似文献
13.
Caiyong Chen Daniel Garcia-Santos Yuichi Ishikawa Alexandra Seguin Liangtao Li Katherine H. Fegan Gordon J. Hildick-Smith Dhvanit I. Shah Jeffrey D. Cooney Wen Chen Matthew J. King Yvette Y. Yien Iman J. Schultz Heidi Anderson Arthur J. Dalton Matthew L. Freedman Paul D. Kingsley James Palis Barry H. Paw 《Cell metabolism》2013,17(3):343-352
Highlights? Snx3 is highly expressed in vertebrate hematopoietic tissues ? Silencing of Snx3 results in anemia and hemoglobin defects in vertebrates ? Snx3 and Vps35 physically interact with Tfrc ? Snx3 is required for endosomal recycling of Tf-Tfrc complex 相似文献
14.
Kensuke Kawade Gorou Horiguchi Takeshi Usami Masami Yokota Hirai Hirokazu Tsukaya 《Current biology : CB》2013,23(9):788-792
Highlights? AN3 is produced specifically in mesophyll cells and moves into epidermal cells ? AN3 participates in the control of epidermal cell proliferation ? AN3 signaling is essential for normal leaf development ? AN3 movement does not require the action of the type II chaperonin complex 相似文献
15.
Ko Sato Elayanambi Sundaramoorthy Eeson Rajendra Hiroyoshi Hattori Anand D. Jeyasekharan Nabieh Ayoub Ralph Schiess Ruedi Aebersold Hiroyuki Nishikawa Anna S. Sedukhina Haruka Wada Tomohiko Ohta Ashok R. Venkitaraman 《Current biology : CB》2012,22(18):1659-1666
Highlights? BRCA1 E3 ligase activity is essential for a subset of DNA damage responses ? BRCA1 V26A mutant cells are sensitive to topoisomerase inhibitors but not mitomycin C ? BRCA1 selectively ubiquitylates claspin after topoisomerase inhibition ? BRCA1 E3 ligase inactivation selectively impairs CHK1 activation 相似文献
16.
Hallows WC Yu W Smith BC Devries MK Devires MK Ellinger JJ Someya S Shortreed MR Prolla T Markley JL Smith LM Zhao S Guan KL Denu JM 《Molecular cell》2011,41(2):139-149
Highlights? High-throughput analyses identify potential targets of Sirt3 ? Sirt3 deacetylates and stimulates ornithine transcarbamoylase ? Caloric restriction induces Sirt3 expression and stimulation of the urea cycle ? Sirt3 regulates amino acid catabolism and β-oxidation during caloric restriction 相似文献
17.
Melissa J. Collins Ilaria Napoli Sara Ribeiro Sinead Roberts Alison C. Lloyd 《Current biology : CB》2012,22(19):1765-1773
Highlights? Oncogenic Ras drives weak growth through the PI3K canonical growth pathway ? A novel E2F-independent role for the Rb family in cell biogenesis ? Ras and loss of Rb synergize to give robust and sustained cell growth ? PI3K pathway is crucial for sustained growth, acting to maintain nutrient uptake 相似文献
18.
Mi-Hyeon Jang Michael A. Bonaguidi Yasuji Kitabatake Jiaqi Sun Juan Song Eunchai Kang Heechul Jun Chun Zhong Yijing Su Junjie U. Guo Marie Xun Wang Kurt A. Sailor Ju-Young Kim Yuan Gao Kimberly M. Christian Guo-li Ming Hongjun Song 《Cell Stem Cell》2013,12(2):215-223
Highlights? Wnt inhibitor sFRP3 exhibits activity-dependent expression in the adult hippocampus ? sFRP3 maintains quiescence of adult hippocampal radial glia-like neural stem cells ? sFRP3 inhibits maturation, dendritic development, and spinal formation of new neurons ? sFRP3 partially mediates activity-dependent adult hippocampal neurogenesis 相似文献
19.
Chengqi Lin Alexander S. Garruss Zhuojuan Luo Fengli Guo Ali Shilatifard 《Cell》2013,152(1-2):144-156
Highlights? Ell3 is preferentially found at active, poised, and inactive enhancers in ES cells ? Promoter-proximal Pol II occupancy at key developmental genes requires Ell3 ? Cohesin functions in Ell3-associated enhancer-promoter communication ? Recruitment of P-TEFb within SEC during differentiation is Ell3 dependent 相似文献
20.
Karin J. Jensen Farshid S. Garmaroudi Jingchun Zhang Jun Lin Seti Boroomand Mary Zhang Zongshu Luo Decheng Yang Honglin Luo Bruce M. McManus Kevin A. Janes 《Cell host & microbe》2013,13(1):67-76
Highlights? Intracellular signaling predicts the fate of coxsackievirus B3 (CVB3)-infected cells ? p38 and ERK signaling pathways are tightly interconnected during CVB3 infection ? CVB3-induced apoptosis of cardiomyocytes is inhibited by ERK5 and ERK1/2 pathways ? CVB3 induces necrosis of cardiomyocytes via p38 activation 相似文献