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1.
Hierarchical generative models, such as Bayesian networks, and belief propagation have been shown to provide a theoretical framework that can account for perceptual processes, including feedforward recognition and feedback modulation. The framework explains both psychophysical and physiological experimental data and maps well onto the hierarchical distributed cortical anatomy. However, the complexity required to model cortical processes makes inference, even using approximate methods, very computationally expensive. Thus, existing object perception models based on this approach are typically limited to tree-structured networks with no loops, use small toy examples or fail to account for certain perceptual aspects such as invariance to transformations or feedback reconstruction. In this study we develop a Bayesian network with an architecture similar to that of HMAX, a biologically-inspired hierarchical model of object recognition, and use loopy belief propagation to approximate the model operations (selectivity and invariance). Crucially, the resulting Bayesian network extends the functionality of HMAX by including top-down recursive feedback. Thus, the proposed model not only achieves successful feedforward recognition invariant to noise, occlusions, and changes in position and size, but is also able to reproduce modulatory effects such as illusory contour completion and attention. Our novel and rigorous methodology covers key aspects such as learning using a layerwise greedy algorithm, combining feedback information from multiple parents and reducing the number of operations required. Overall, this work extends an established model of object recognition to include high-level feedback modulation, based on state-of-the-art probabilistic approaches. The methodology employed, consistent with evidence from the visual cortex, can be potentially generalized to build models of hierarchical perceptual organization that include top-down and bottom-up interactions, for example, in other sensory modalities. 相似文献
2.
Asymmetric regression is an alternative to conventional linear regression that allows us to model the relationship between predictor variables and the response variable while accommodating skewness. Advantages of asymmetric regression include incorporating realistic ecological patterns observed in data, robustness to model misspecification and less sensitivity to outliers. Bayesian asymmetric regression relies on asymmetric distributions such as the asymmetric Laplace (ALD) or asymmetric normal (AND) in place of the normal distribution used in classic linear regression models. Asymmetric regression concepts can be used for process and parameter components of hierarchical Bayesian models and have a wide range of applications in data analyses. In particular, asymmetric regression allows us to fit more realistic statistical models to skewed data and pairs well with Bayesian inference. We first describe asymmetric regression using the ALD and AND. Second, we show how the ALD and AND can be used for Bayesian quantile and expectile regression for continuous response data. Third, we consider an extension to generalize Bayesian asymmetric regression to survey data consisting of counts of objects. Fourth, we describe a regression model using the ALD, and show that it can be applied to add needed flexibility, resulting in better predictive models compared to Poisson or negative binomial regression. We demonstrate concepts by analyzing a data set consisting of counts of Henslow’s sparrows following prescribed fire and provide annotated computer code to facilitate implementation. Our results suggest Bayesian asymmetric regression is an essential component of a scientist’s statistical toolbox. 相似文献
3.
Steinschneider et al. (2017) investigate model choices made in the hierarchical climate reconstruction approach of Schofield et al. (2016). We identify two flaws in their approach. The first is the use of an unusual approximation to Bayesian inference that unnecessarily discards important information. The second is that they mischaracterize the robustness of their reconstructions due to overlooking important features of the out-of-sample predictions. We demonstrate how full Bayesian inference can be conducted with no additional effort, providing R/JAGS code. We also show how graphical visualization of the out-of-sample predictions can lead to better understanding and comparison of the models fitted. 相似文献
4.
The principles by which networks of neurons compute, and how spike-timing dependent plasticity (STDP) of synaptic weights generates and maintains their computational function, are unknown. Preceding work has shown that soft winner-take-all (WTA) circuits, where pyramidal neurons inhibit each other via interneurons, are a common motif of cortical microcircuits. We show through theoretical analysis and computer simulations that Bayesian computation is induced in these network motifs through STDP in combination with activity-dependent changes in the excitability of neurons. The fundamental components of this emergent Bayesian computation are priors that result from adaptation of neuronal excitability and implicit generative models for hidden causes that are created in the synaptic weights through STDP. In fact, a surprising result is that STDP is able to approximate a powerful principle for fitting such implicit generative models to high-dimensional spike inputs: Expectation Maximization. Our results suggest that the experimentally observed spontaneous activity and trial-to-trial variability of cortical neurons are essential features of their information processing capability, since their functional role is to represent probability distributions rather than static neural codes. Furthermore it suggests networks of Bayesian computation modules as a new model for distributed information processing in the cortex. 相似文献
5.
Gupta M 《Biometrics》2007,63(3):797-805
A generalized hierarchical Markov model for sequences that contain length-restricted features is introduced. This model is motivated by the recent development of high-density tiling array data for determining genomic elements of functional importance. Due to length constraints on certain features of interest, as well as variability in probe behavior, usual hidden Markov-type models are not always applicable. A robust Bayesian framework that can incorporate length constraints, probe variability, and bias is developed. Moreover, a novel recursion-based Monte Carlo algorithm is proposed to estimate the parameters and impute hidden states under length constraints. Application of this methodology to yeast chromosomal arrays demonstrate substantial improvement over currently existing methods in terms of sensitivity as well as biological interpretability. 相似文献
6.
Hierarchical organization of macaque and cat cortical sensory systems explored with a novel network processor 总被引:6,自引:0,他引:6
Hilgetag CC O'Neill MA Young MP 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》2000,355(1393):71-89
Neuroanatomists have described a large number of connections between the various structures of monkey and cat cortical sensory systems. Because of the complexity of the connection data, analysis is required to unravel what principles of organization they imply. To date, analysis of laminar origin and termination connection data to reveal hierarchical relationships between the cortical areas has been the most widely acknowledged approach. We programmed a network processor that searches for optimal hierarchical orderings of cortical areas given known hierarchical constraints and rules for their interpretation. For all cortical systems and all cost functions, the processor found a multitude of equally low-cost hierarchies. Laminar hierarchical constraints that are presently available in the anatomical literature were therefore insufficient to constrain a unique ordering for any of the sensory systems we analysed. Hierarchical orderings of the monkey visual system that have been widely reported, but which were derived by hand, were not among the optimal orderings. All the cortical systems we studied displayed a significant degree of hierarchical organization, and the anatomical constraints from the monkey visual and somato-motor systems were satisfied with very few constraint violations in the optimal hierarchies. The visual and somato-motor systems in that animal were therefore surprisingly strictly hierarchical. Most inconsistencies between the constraints and the hierarchical relationships in the optimal structures for the visual system were related to connections of area FST (fundus of superior temporal sulcus). We found that the hierarchical solutions could be further improved by assuming that FST consists of two areas, which differ in the nature of their projections. Indeed, we found that perfect hierarchical arrangements of the primate visual system, without any violation of anatomical constraints, could be obtained under two reasonable conditions, namely the subdivision of FST into two distinct areas, whose connectivity we predict, and the abolition of at least one of the less reliable rule constraints. Our analyses showed that the future collection of the same type of laminar constraints, or the inclusion of new hierarchical constraints from thalamocortical connections, will not resolve the problem of multiple optimal hierarchical representations for the primate visual system. Further data, however, may help to specify the relative ordering of some more areas. This indeterminacy of the visual hierarchy is in part due to the reported absence of some connections between cortical areas. These absences are consistent with limited cross-talk between differentiated processing streams in the system. Hence, hierarchical representation of the visual system is affected by, and must take into account, other organizational features, such as processing streams. 相似文献
7.
Trevor J. Hefley Mevin B. Hooten Robin E. Russell Daniel P. Walsh James A. Powell 《Ecology letters》2017,20(5):640-650
Ecological diffusion is a theory that can be used to understand and forecast spatio‐temporal processes such as dispersal, invasion, and the spread of disease. Hierarchical Bayesian modelling provides a framework to make statistical inference and probabilistic forecasts, using mechanistic ecological models. To illustrate, we show how hierarchical Bayesian models of ecological diffusion can be implemented for large data sets that are distributed densely across space and time. The hierarchical Bayesian approach is used to understand and forecast the growth and geographic spread in the prevalence of chronic wasting disease in white‐tailed deer (Odocoileus virginianus). We compare statistical inference and forecasts from our hierarchical Bayesian model to phenomenological regression‐based methods that are commonly used to analyse spatial occurrence data. The mechanistic statistical model based on ecological diffusion led to important ecological insights, obviated a commonly ignored type of collinearity, and was the most accurate method for forecasting. 相似文献
8.
Heath TA 《Systematic biology》2012,61(5):793-809
In Bayesian divergence time estimation methods, incorporating calibrating information from the fossil record is commonly done by assigning prior densities to ancestral nodes in the tree. Calibration prior densities are typically parametric distributions offset by minimum age estimates provided by the fossil record. Specification of the parameters of calibration densities requires the user to quantify his or her prior knowledge of the age of the ancestral node relative to the age of its calibrating fossil. The values of these parameters can, potentially, result in biased estimates of node ages if they lead to overly informative prior distributions. Accordingly, determining parameter values that lead to adequate prior densities is not straightforward. In this study, I present a hierarchical Bayesian model for calibrating divergence time analyses with multiple fossil age constraints. This approach applies a Dirichlet process prior as a hyperprior on the parameters of calibration prior densities. Specifically, this model assumes that the rate parameters of exponential prior distributions on calibrated nodes are distributed according to a Dirichlet process, whereby the rate parameters are clustered into distinct parameter categories. Both simulated and biological data are analyzed to evaluate the performance of the Dirichlet process hyperprior. Compared with fixed exponential prior densities, the hierarchical Bayesian approach results in more accurate and precise estimates of internal node ages. When this hyperprior is applied using Markov chain Monte Carlo methods, the ages of calibrated nodes are sampled from mixtures of exponential distributions and uncertainty in the values of calibration density parameters is taken into account. 相似文献
9.
The brain can learn and detect mixed input signals masked by various types of noise, and spike-timing-dependent plasticity (STDP) is the candidate synaptic level mechanism. Because sensory inputs typically have spike correlation, and local circuits have dense feedback connections, input spikes cause the propagation of spike correlation in lateral circuits; however, it is largely unknown how this secondary correlation generated by lateral circuits influences learning processes through STDP, or whether it is beneficial to achieve efficient spike-based learning from uncertain stimuli. To explore the answers to these questions, we construct models of feedforward networks with lateral inhibitory circuits and study how propagated correlation influences STDP learning, and what kind of learning algorithm such circuits achieve. We derive analytical conditions at which neurons detect minor signals with STDP, and show that depending on the origin of the noise, different correlation timescales are useful for learning. In particular, we show that non-precise spike correlation is beneficial for learning in the presence of cross-talk noise. We also show that by considering excitatory and inhibitory STDP at lateral connections, the circuit can acquire a lateral structure optimal for signal detection. In addition, we demonstrate that the model performs blind source separation in a manner similar to the sequential sampling approximation of the Bayesian independent component analysis algorithm. Our results provide a basic understanding of STDP learning in feedback circuits by integrating analyses from both dynamical systems and information theory. 相似文献
10.
How does the cerebral cortex work? Learning, attention, and grouping by the laminar circuits of visual cortex 总被引:3,自引:0,他引:3
Grossberg S 《Spatial Vision》1999,12(2):163-185
The organization of neocortex into layers is one of its most salient anatomical features. These layers include circuits that form functional columns in cortical maps. A major unsolved problem concerns how bottom-up, top-down, and horizontal interactions are organized within cortical layers to generate adaptive behaviors. This article models how these interactions help visual cortex to realize: (i) the binding process whereby cortex groups distributed data into coherent object representations; (ii) the attentional process whereby cortex selectively processes important events; and (iii) the developmental and learning processes whereby cortex shapes its circuits to match environmental constraints. New computational ideas about feedback systems suggest how neocortex develops and learns in a stable way, and why top-down attention requires converging bottom-up inputs to fully activate cortical cells, whereas perceptual groupings do not. 相似文献
11.
A major issue in cortical physiology and computational neuroscience is understanding the interaction between extrinsic signals
from feedforward connections and intracortical signals from lateral connections. We propose here a computational model for
motion perception based on the assumption that the local cortical circuits in the medio-temporal area (area MT) implement
a Bayesian inference principle. This approach establishes a functional balance between feedforward and lateral, excitatory
and inhibitory, inputs. The model reproduces most of the known properties of the neurons in area MT in response to moving
stimuli. It accounts for important motion perception phenomena including motion transparency, spatial and temporal integration/segmentation.
While integrating several properties of previously proposed models, it makes specific testable predictions concerning, in
particular, temporal properties of neurons and the architecture of lateral connections in area MT. In addition, the proposed
mechanism is consistent with the known properties of local cortical circuits in area V1. This suggests that Bayesian inference
may be a general feature of information processing in cortical neuron populations.
Received: 3 December 1997 / Accepted in revised form: 21 July 1998 相似文献
12.
G E Hinton Z Ghahramani 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》1997,352(1358):1177-1190
We describe a hierarchical, generative model that can be viewed as a nonlinear generalization of factor analysis and can be implemented in a neural network. The model uses bottom-up, top-down and lateral connections to perform Bayesian perceptual inference correctly. Once perceptual inference has been performed the connection strengths can be updated using a very simple learning rule that only requires locally available information. We demonstrate that the network learns to extract sparse, distributed, hierarchical representations. 相似文献
13.
Learning is often understood as an organism''s gradual acquisition of the association between a given sensory stimulus and the correct motor response. Mathematically, this corresponds to regressing a mapping between the set of observations and the set of actions. Recently, however, it has been shown both in cognitive and motor neuroscience that humans are not only able to learn particular stimulus-response mappings, but are also able to extract abstract structural invariants that facilitate generalization to novel tasks. Here we show how such structure learning can enhance facilitation in a sensorimotor association task performed by human subjects. Using regression and reinforcement learning models we show that the observed facilitation cannot be explained by these basic models of learning stimulus-response associations. We show, however, that the observed data can be explained by a hierarchical Bayesian model that performs structure learning. In line with previous results from cognitive tasks, this suggests that hierarchical Bayesian inference might provide a common framework to explain both the learning of specific stimulus-response associations and the learning of abstract structures that are shared by different task environments. 相似文献
14.
《Electronic Notes in Theoretical Computer Science》1990,77(2):156-160
When a stimulus is presented to a subject, different cortical areas are activated simultaneously. These cortical sources are the generators of evoked potentials. The geometry parameters and the amplitude time course of each source can be estimated on the basis of EP data and the appropriate mathematical model. In the present paper, a model is proposed which describes EPs as the result of a set of stagnant dipoles, with time varying amplitude. It is shown how the parameter estimation problem can be solved efficiently. The method automatically solves the problem of separating overlapping components. A lower limit for the residual is derived, which can be used to determine the minimum number of sources required to describe observed responses adequately. 相似文献
15.
It has previously been shown that generic cortical microcircuit models can perform complex real-time computations on continuous input streams, provided that these computations can be carried out with a rapidly fading memory. We investigate the computational capability of such circuits in the more realistic case where not only readout neurons, but in addition a few neurons within the circuit, have been trained for specific tasks. This is essentially equivalent to the case where the output of trained readout neurons is fed back into the circuit. We show that this new model overcomes the limitation of a rapidly fading memory. In fact, we prove that in the idealized case without noise it can carry out any conceivable digital or analog computation on time-varying inputs. But even with noise, the resulting computational model can perform a large class of biologically relevant real-time computations that require a nonfading memory. We demonstrate these computational implications of feedback both theoretically, and through computer simulations of detailed cortical microcircuit models that are subject to noise and have complex inherent dynamics. We show that the application of simple learning procedures (such as linear regression or perceptron learning) to a few neurons enables such circuits to represent time over behaviorally relevant long time spans, to integrate evidence from incoming spike trains over longer periods of time, and to process new information contained in such spike trains in diverse ways according to the current internal state of the circuit. In particular we show that such generic cortical microcircuits with feedback provide a new model for working memory that is consistent with a large set of biological constraints. Although this article examines primarily the computational role of feedback in circuits of neurons, the mathematical principles on which its analysis is based apply to a variety of dynamical systems. Hence they may also throw new light on the computational role of feedback in other complex biological dynamical systems, such as, for example, genetic regulatory networks. 相似文献
16.
The use of mutual information as a similarity measure in agglomerative hierarchical clustering (AHC) raises an important issue: some correction needs to be applied for the dimensionality of variables. In this work, we formulate the decision of merging dependent multivariate normal variables in an AHC procedure as a Bayesian model comparison. We found that the Bayesian formulation naturally shrinks the empirical covariance matrix towards a matrix set a priori (e.g., the identity), provides an automated stopping rule, and corrects for dimensionality using a term that scales up the measure as a function of the dimensionality of the variables. Also, the resulting log Bayes factor is asymptotically proportional to the plug-in estimate of mutual information, with an additive correction for dimensionality in agreement with the Bayesian information criterion. We investigated the behavior of these Bayesian alternatives (in exact and asymptotic forms) to mutual information on simulated and real data. An encouraging result was first derived on simulations: the hierarchical clustering based on the log Bayes factor outperformed off-the-shelf clustering techniques as well as raw and normalized mutual information in terms of classification accuracy. On a toy example, we found that the Bayesian approaches led to results that were similar to those of mutual information clustering techniques, with the advantage of an automated thresholding. On real functional magnetic resonance imaging (fMRI) datasets measuring brain activity, it identified clusters consistent with the established outcome of standard procedures. On this application, normalized mutual information had a highly atypical behavior, in the sense that it systematically favored very large clusters. These initial experiments suggest that the proposed Bayesian alternatives to mutual information are a useful new tool for hierarchical clustering. 相似文献
17.
Summary Absence of a perfect reference test is an acknowledged source of bias in diagnostic studies. In the case of tuberculous pleuritis, standard reference tests such as smear microscopy, culture and biopsy have poor sensitivity. Yet meta‐analyses of new tests for this disease have always assumed the reference standard is perfect, leading to biased estimates of the new test’s accuracy. We describe a method for joint meta‐analysis of sensitivity and specificity of the diagnostic test under evaluation, while considering the imperfect nature of the reference standard. We use a Bayesian hierarchical model that takes into account within‐ and between‐study variability. We show how to obtain pooled estimates of sensitivity and specificity, and how to plot a hierarchical summary receiver operating characteristic curve. We describe extensions of the model to situations where multiple reference tests are used, and where index and reference tests are conditionally dependent. The performance of the model is evaluated using simulations and illustrated using data from a meta‐analysis of nucleic acid amplification tests (NAATs) for tuberculous pleuritis. The estimate of NAAT specificity was higher and the sensitivity lower compared to a model that assumed that the reference test was perfect. 相似文献
18.
Using Bayesian networks to analyze expression data. 总被引:44,自引:0,他引:44
19.
Assessment of brain connectivity among different brain areas during cognitive or motor tasks is a crucial problem in neuroscience
today. Aim of this work is to use a neural mass model to assess the effect of various connectivity patterns in cortical electroencephalogram
(EEG) power spectral density, and investigate the possibility to derive connectivity circuits from EEG data. To this end,
a model of an individual region of interest (ROI) has been built as the parallel arrangement of three populations, each described
as in Wendling et al. (Eur J Neurosci 15:1499–1508, 2002). Connectivity among ROIs includes three parameters, which specify
the strength of connection in the different frequency bands. The following main steps have been followed: (1) we analyzed
how the power spectral density (PSD) is significantly modified by the kind of coupling hypothesized among the ROIs; (2) with
the model, and using an automatic fitting procedure, we looked for a simple connectivity circuit able to reproduce PSD of
cortical EEG in three ROIs during a finger-movement task. The estimated parameters represent the strength of connections among
the ROIs in the different frequency bands. Cortical EEGs were computed with an inverse propagation algorithm, starting from
measurement performed with 96 electrodes on the scalp. The present study suggests that the model can be used as a simulation
tool, able to mimic the effect of connectivity on EEG. Moreover, it can be used to look for simple connectivity circuits,
able to explain the main features of observed cortical PSD. These results may open new prospectives in the use of neurophysiological
models, instead of empirical models, to assess effective connectivity from neuroimaging information. 相似文献
20.
A Hierarchical Bayesian Design for Phase I Trials of Novel Combinations of Cancer Therapeutic Agents
Summary We propose a hierarchical model for the probability of dose‐limiting toxicity (DLT) for combinations of doses of two therapeutic agents. We apply this model to an adaptive Bayesian trial algorithm whose goal is to identify combinations with DLT rates close to a prespecified target rate. We describe methods for generating prior distributions for the parameters in our model from a basic set of information elicited from clinical investigators. We survey the performance of our algorithm in a series of simulations of a hypothetical trial that examines combinations of four doses of two agents. We also compare the performance of our approach to two existing methods and assess the sensitivity of our approach to the chosen prior distribution. 相似文献