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1.
Aydin Ece Bekir Sami Uyamik Akin IŞcan Pelin Ertan M. Ramazan Yiğitolu 《Biological trace element research》1997,59(1-3):31-39
In order to evaluate serum copper and zinc status in children with iron deficiency anemia (IDA), 60 children with IDA aged
1–14 yr and 64 healthy children as controls aged 1–14 yr were included the study. Serum copper levels were higher in children
with IDA (189 ± 49 (Μg/dL) than those of controls (163 ± 37 Μg/dL) (p = 0.001). Serum zinc levels were lower in the patient group (109 ± 59 Μg/dL) than those of control subjects (135 ± 56 Μg/dL)
(p = 0.017). In addition, there were statistically significant negative correlations between hematological parameters and serum
copper levels in the patient group, but not in controls. No correlation between hematological parameters and serum zinc levels
were found in both patient and control groups, except positive correlation between mean corpuscular volume (MCV) and serum
zinc level in patients.
It was concluded that at the time of managing children with IDA, zinc deficiency must be borne in mind and if necessary treatment
should be initiated with zinc. 相似文献
2.
Plasma selenium status in children with iron deficiency anemia 总被引:2,自引:0,他引:2
Metin Kaya Gürgze A. Denizmen Aygün Ali
lücü Yasar Doan Erdal Ylmaz 《Journal of trace elements in medicine and biology》2004,18(2):193-196
Iron and selenium are trace elements necessary for the maintenance of life and health. Iron deficiency is the most common nutritional deficiency among children in the world. The purpose of this study was to evaluate plasma selenium concentrations in children with iron deficiency anemia (IDA). Plasma selenium levels were investigated in 56 children with IDA and in 48 control subjects aged 1-8 years. A spectrofluorometric method was used for the determination. Plasma selenium concentrations in children with IDA (33.6+/-8.2 microg/l) were significantly lower than in the control group (56.0+/-17.0 microg/l) (p<0.001). However, there was no relation between plasma selenium, iron and hemoglobin concentrations. 相似文献
3.
Antonella Bertazzo Carlo Costa Monica Biasiolo Graziella Allegri Girolamo Cirrincione Giuseppe Presti 《Biological trace element research》1996,52(1):37-53
The Cu and Zn levels of both 607 men (1–85 y old) and 649 women (1–92 y old) were determined by atomic absorption spectrometry.
Sex does not influence Cu (14.89±0.89 μg/g and 15.26±0.79 μg/g hair for males and females, respectively) and Zn contents (200.97±9.68
μg/g for men and 209.81±9.49 μg/g hair for women). Age influences Cu and Zn concentrations, but only significantly in females:
Cu levels decrease over 60 y of age; whereas Zn levels increase significantly from age groups 2–5 to 20–40 years. Hair color
influences Cu concentrations in both males and females. In males, white hair containes less Cu than black hair; in females,
white hair's Cu levels are significantly lower than those of dark blond, red, light brown, and brown hair. There are no significant
differences in Zn concentrations with respect to different hair colors, in either males or females. 相似文献
4.
A number of essential trace elements play a major role in various metabolic pathways. Selenium (Se), manganese (Mn), copper
(Cu), zinc (Zn), and iron (Fe) are essential trace elements that have been studied in many diseases, including autoimmune,
neurological, and psychiatric disorders. However, the findings of previous research on the status of trace elements in patients
with schizophrenia have been controversial. We studied these elements in patients with a DSM-IV diagnosis of schizophrenia
and compared them with sex- and age-matched healthy controls. Plasma Cu concentrations were significantly higher (p<0.01) and Mn and Fe concentrations were lower (p<0.05 and p<0.05, respectively) in schizophrenic patients than in controls. Se and Zn concentrations and protein levels did not differ
between patients and healthy controls. These observations suggest that alterations in essential trace elements Mn, Cu, and
Fe may play a role in the pathogenesis of schizophrenia. However, findings from trace element levels in schizophrenia show
a variety of results that are difficult to interpret. 相似文献
5.
Plasma essential trace elements, selenium, copper, zinc, and iron concentrations and the levels of immunoregulatory cytokines,
interleukin-1β (IL-1β), interleukin-2 receptor (IL-2r), IL-6, IL-8, and tumor necrosis factor-α (TNF-α) were evaluated in patients with cutaneous leishmaniasis (CL) to investigate a possible role of these cytokines on selenium,
zinc, copper, and iron homeostasis in CL patients. Plasma albumin levels were measured as an index of nutritional status.
Plasma selenium, zinc, and iron concentrations, and IL-2r levels were significantly lower, and copper concentrations and IL-1β, IL-8, IL-6 and TNF-α levels were significantly higher in patients with CL than those of healthy controls. There was no significant difference
in plasma albumin levels between two groups. There were positive important correlations between plasma selenium and IL-2r,
copper and IL-6, and copper and IL-1β, and negative correlations between selenium and IL-8, iron and TNF-α, and zinc and IL-1β contents in patients with CL. Our results showed that plasma trace element contents change in patients with CL. These changes
may not be a result of a specific deficiency from dietary inadequacies or imbalances, but, probably, a result of a part of
the defense strategies of an organism that is regulated by immunoregulatory cytokines. 相似文献
6.
Hair zinc and copper: Relationship to hair type and serum concentrations in children and adolescents
The zinc and copper serum and hair concentrations of 691 3-18-y-old girls and boys previously determined as a part of the
Multicentre Study of Atherosclerosis Precursors in Finnish Children and Adolescents were further analyzed in order to find
a possible association between these two zinc and copper indices. The influence of hair color and the diameter of individual
hair strands on hair concentrations were studied by the analysis of covariance. Hair color and serum zinc concentrations were
found to be associated with hair zinc concentrations in boys. Such an association was not found for zinc and copper concentrations
in girls. Hair vs serum concentrations in different age and hair color groups did not show however, a significant relationship
either in copper or in zinc concentrations. The subjects with very low or high serum zinc or copper concentrations did not
usually have extreme hair concentrations and vice versa. However, there were some subjects with low or high serum concentrations
associated with low or high hair concentrations. 相似文献
7.
In recent years, a great number of studies have investigated the possible role of trace elements in the etiology and pathogenesis
of rheumatoid arthritis (RA) and osteoartritis (OA). We studied synovial fluid and plasma concentrations of selenium (Se),
zinc (Zn), copper (Cu), and iron (Fe) in patients with RA and OA and compared them with sex- and age-matched healthy subjects.
Plasma albumin levels were measured as an index of nutritional status. Plasma Se, Cu, and Zn concentrations were determined
by atomic absorption spectrophotometry and Fe concentrations were determined by the colorimetric method. Although plasma and
synovial fluid Se concentration were found to be significantly lower (p<0.05, and p<0.05, respectively), Cu concentrations were significantly higher in patients with RA than those of healthy subjects and OA
(p<0.05 and p<0.05, respectively). There were no significant differences in plasma and synovial fluid Zn concentrations and albumin levels
among three groups (p>0.05). On the other hand, synovial fluid Cu and Fe concentrations were significantly higher in patients with OA than those
of healthy subjects (p<0.05). There was a significantly positive correlation between synovial fluid Se−Cu values and Zn−Fe values in patients with
RA. Our results showed that synovial fluid and plasma trace element concentrations, excluding Zn, change in inflammatory RA,
but not in OA. These alterations in trace element concentrations in inflammatory Ra might be a result on the changes of the
immunoregulatory cytokines. 相似文献
8.
9.
Ciftci TU Ciftci B Yis O Guney Y Bilgihan A Ogretensoy M 《Biological trace element research》2003,95(1):65-71
The effectiveness and success of antituberculosis therapy is mainly measured by its ability to identify the organism in the
sputum. In certain cases, available tuberculosis tests are not satisfactory and do not provide enough information on the effectiveness
of antituberculosis therapy. Copper (Cu), zinc (Zn), and selenium (Se) are the essential elements that play a crucial role
in the immune system. The serum levels of these elements vary in many diseases including tuberculosis. In this study, we investigate
whether the serum levels of Cu, Zn, and Se change during antituberculosis therapy. We have included 22 pulmonary tuberculosis
cases that were newly diagnosed with positive sputum and 18 healthy subjects. At the beginning and 2 mo after therapy, serum
levels of Cu, Zn, and Se were measured by atomic absorption spectrometry. Despite Se and Cu levels not being affected during
the treatment, we found that there was a significant increase in the levels of Zn and a decrease in the Cu/Zn ratio. Serum
Zn levels and the Cu/Zn ratio could be used as a valuable laboratory tool for the clinicians to assess response to therapy
or effectiveness of the ongoing antituberculosis therapy. 相似文献
10.
Neural tube defects are important causes of infant mortality and childhood morbidity. We investigated the relationship between
zinc, selenium, copper, and lead concentrations and neural-tube-defect occurrence in women with a second-trimester termination
due to fetal-neural-tube defects (NTDs) in this case-control study. Fourteen pregnant women whose pregnancies were terminated
as a result of second-trimester ultrasonographic diagnosis of neural tube defects were recruited as cases. The control group
(n=14) consisted of women who were selected among age-, gravidity-, and socio-economic-state (SES)-matched women who had a normal
triple-screen and targeted ultrasound during the second trimester with documented normal fetal outcome. Zinc and copper determinations
were made using flame atomic absorption spectrophotometer (AAS). Graphite furnace AAS was used for Pb, and Se levels were
measured with hydride generation AAS. Cases had significantly low serum zinc and selenium levels (62.48±15.9 vs 102.6±23.7
and 55.16±11.3 vs 77.4±5.5, respectively, p<0.001). Serum Cu and whole-blood Pb levels were significantly high when compared to controls. There was a negative correlation
between serum zinc and selenium levels, and serum copper levels (r=−425 and −0.443, p<0.05). Our results are consistent with some previous reports. The etiology of NTDs cannot be explained with one strict etiologic
mechanism. On the contrary, an interaction among environmental, genetic, and nutritional factors such as trace elements and
vitamins would explain these anomalies. If folic acid supplementation is given, additional Zn supplementation should be considered
for the further decrease in the recurrence and occurrence of NTDs. 相似文献
11.
Van Nhien N Khan NC Yabutani T Ninh NX Kassu A Huong BT Do TT Motonaka J Ota F 《Biological trace element research》2006,111(1-3):1-9
This study was aimed at assessing the serum levels of vitamin A, copper, zinc, selenium, and iron among adult Vietnamese with
and without iron-deficiency anemia. Blood was collected from adult Vietnamese living in the midland of northern Vietnam. One
hundred twenty-three subjects in the age range 20–60 yr were included in the study. Anemia, where the concentration of hemoglobin
in whole blood is less than 120 g/L in females and 130 g/L in males, was found in 30% (37/123) of the study population. The
levels of vitamin A and selenium in the sera of anemic subjects (n=37) were significantly lower than that in nonanemic group (n=86). On the other hand, no significant differences were observed in the concentrations of copper and zinc between the two
groups. This study was the first to show serum levels of trace elements in adult Vietnamese, providing useful baseline information
for further studies. 相似文献
12.
The objective of the study was to determine whether iron and micronutrient status is improved with an increased amount of
meat in the diet. To this end, a longitudinal prospective study with infants recruited at 4 mo and followed until 24 mo of
age was undertaken. One hundred ninety-eight infants formed the original study cohort; 48 withdrew before the end of the study.
Subjects were classified as nonmeat eaters or as mixed (red and white)-meat eaters subgrouped into tertiles depending on the
meat content reported in diet diaries. Seven-day weighed food records were recorded at 4, 8, 12, 16, 20, and 24 mo. Blood
samples taken at 4, 12, and 24 mo were analyzed for parameters of iron and micronutrient status. Iron intake increased during
the first year, thereafter remaining constant. The percentages of subjects with hemoglobin values below 110 g/L were 34.1,
23.1, and 13.4 at 4, 12, and 24 mo, respectively. For parameters of iron status, the number of results below the reference
range was determined for each diet group and a significant negative relationship between serum iron and meat intake at 12
mo of age was seen (p<0.023). There was a trend for hemoglobin concentrations to be inversely related to the meat intake, at the same age (p<0.068). No effects on zinc or copper status were seen. We conclude that a weak association between dietary meat and iron/Hb
suggests a positive role for red meat. There was no disadvantage to the nonmeat-eating infants with respect to zinc or copper. 相似文献
13.
Lead, copper, zinc, and magnesium content in hair of children and young people with some neurological diseases 总被引:1,自引:0,他引:1
Lech T 《Biological trace element research》2002,85(2):111-126
The lead, copper, zinc, and magnesium levels of scalp hair taken from 153 children aged 1–15 yr and young people (16–18 yr)
with selected neurological disorders (hyperexcibility, loss of consciousness, and epileptiform convulsions of an unknown origin,
etc.), were measured using the atomic absorption spectrometry method and then compared with a control group of healthy children
(n=108). The research indicated significantly reduced mean levels of magnesium in the hair of children suffering from selected
neurological diseases (in children aged 11–15 yr of age, above 30%; up to 5 yr of age, nearly 30%; the differences were statistically
significant at p<0.05) and slightly decreased mean levels of copper (differences statistically significant at p<0.05, particularly in the 11 to 15-yr category). Differences in zinc levels in hair were inconsiderable (not statistically
significant in any age groups). The lead level in the hair of the above-mentioned group of children was exceeded in relation
to the control group (a statistically significant difference at p<0.05 for the total group). A more than twofold decrease in the mean value of the Mg/Pb ratio (and a nearly 30% decrease in
the value of the Mg/Zn ratio) in the hair of children suffering from neurological diseases suggests that the high toxicity
of lead accompanying, among other things, magnesium deficiencies might be a cause of the observed disorders in children. 相似文献
14.
Mahomed K Williams MA Woelk GB Mudzamiri S Madzime S King IB Bankson DD 《Biological trace element research》2000,75(1-3):107-118
Preeclampsia is an important cause of maternal and perinatal mortality worldwide. The etiology of this relatively common medical
complication of pregnancy, however, remains unknown. We studied the relationship between maternal leukocyte selenium, zinc,
and copper concentrations and the risk of preeclampsia in a large hospital-based case-control study. One hundred seventy-one
women with proteinuric pregnancy-induced hypertension (with or without seizures) comprised the case group. Controls were 184
normotensive pregnant women. Leukocytes were separated from blood samples collected during the patients’ postpartum labor
and delivery admission. Leukocyte concentrations for the three cations were measured by inductively coupled plasma-mass spectrometry
(ICP-MS). Concentrations for each cation were reported as micrograms per gram of total protein. Women with preeclampsia had
significantly higher median leukocyte selenium concentrations than normotensive controls (3.23 vs 2.80 μg/g total protein,
p<0.0001). Median leukocyte zinc concentrations were 31% higher in preeclamptics as compared with controls (179.15 vs 136.44
μg/g total protein, p<0.0001). Although median leukocyte copper concentrations were slightly higher for cases than controls, this difference did
not reach statistical significance (17.72 vs 17.00 μg/g total protein, p=0.468). There was evidence of a linear increase in risk of preeclampsia with increasing concentrations of selenium and zinc.
The relative risk for preeclampsia was 3.38 (adjusted odds ratio [OR]=3.38, 95% confidence interval [CI]=1.53–7.54) among
women in the highest quartile of the control selenium distribution compared with women in the lowest quartile. The corresponding
relative risk and 95% CI for preeclampsia was 5.30 (2.45–11.44) for women in the highest quartile of the control zinc distribution
compared with women in the lowest quartile. There was no clear pattern of a linear trend in risk with increasing concentration
of leukocyte copper concentrations (adjusted for linear trend in risk =0.299). Our results are consistent with some previous
reports. Prospective studies are needed to determine whether observed alterations in selenium and zinc concentrations precede
preeclampsia or whether the differences may be attributed to preeclampsia-related alterations in maternal and fetal-placental
trace metal metabolism. 相似文献
15.
To clarify the changes of mineral levels in different tissues of riboflavin-deficient rats, Wistar rats were separated into
three groups. One group was fed a diet ad libitum that was deficient in riboflavin. The other two were fed either the complete
diet that was weight-matched to the riboflavin-deficient group or fed a complete diet ad libitum. In riboflavin-deficient
rats, the hemoglobin concentration and riboflavin contents of blood, liver, and kidney were significantly decreased, compared
with weight-matched and ad libitum-fed controls. The mineral concentrations of tissues are summarized as follows: The iron
(Fe) concentration in the heart, liver, and spleen was decreased in the riboflavin-deficient group compared with the other
groups. Calcium (Ca) and magnesium (Mg) concentrations in tibia were decreased in the riboflavin-deficient group compared
with the other two groups. Copper (Cu) concentration was increased in the heart and liver when the riboflavin-deficient group
was compared with the other groups. Zinc (Zn) concentration was increased in tibia when the riboflavin-deficient group was
compared with the other groups. 相似文献
16.
Lino Piccinini Paola Borella Annalisa Bargellini Cristina Incerti Medici Alessandra Zoboli 《Biological trace element research》1996,51(1):23-30
The purpose of our study was to investigate the relationship between plasma and hair levels of Se, Zn, and Cu, and cancer.
We selected a total of 66 patients affected by either breast (38) or lung (28) cancer. They entered into the study at the
onset of disease, and before any chemical or radiotherapy. Controls were randomly selected among healthy people and were matched
for sex, age, smoking habits, and residence. In the group of breast cancer, a significant decrease in hair Se was found compared
to controls (p<0.01), whereas plasma Se was only slightly decreased. No difference between cases and controls was detected in both hair
and plasma levels of Zn and Cu. Subjects who developed lung cancer were significantly lower in hair Zn (p<0.05) and Cu (p<0.01) than controls, whereas there was no difference with regard to Se. In addition, plasma Cu of these patients was increased
as compared to controls. 相似文献
17.
The concentration of zinc, copper, selenium, albumin, and ceruloplasmin in blood plasma and the activity of superoxide dismutase
and glutathione peroxidase in erythrocytes were determined in a set of patients with idiopathic scoliosis (n=51). A significant decrease of selenium concentration (0.50±0.16 μmol/L) was found when compared with a control group (0.69±0.07
μmol/L) (p<0.01). The same levels of significance were found out for selenium levels corrected for albumin content. In a group of patients
with a curvature over 45° indicated for a surgical correction, the average plasma concentrations of selenium were significantly
lower (p<0.05) in comparison with a group of patients with a curvature below 45° treated conservatively.
The GSH-Px activity in erythrocytes was the same in both sets. In comparison with the controls, no significant differences
were revealed in all of the other parameters. The detection of the decreased blood plasma concentration of selenium has suggested
possible disturbance of well-proportioned distribution and of general optimal availability of selenium in the organism of
patients with idiopathic scoliosis with likely effects on the process of synthesis and maturation of collagen affecting the
axial skeleton stability. 相似文献
18.
Lech T 《Biological trace element research》2002,89(2):111-125
The lead, copper, zinc, and magnesium contents of scalp hair taken from 173 children aged 1–15 yr and young people (16–18
yr) with certain disorders of the osteomuscular articular system (osteomuscular pains of unknown origin, once described as
“growing pains”) were measured, using the flame atomic absorption spectrometry method, and then compared with those of 108
normal, healthy children. The research showed increased average levels of lead (a statistically significant p<0.05 in both the overall group of children, and in those over 11 yr old), and zinc (increased in the total group, in a statistically
significant way at p<0.10 only in adolescents over 15 yr old) and decreased levels of copper (although not significantly) in the hair of children
suffering from “rheumatic” diseases, as compared with controls. The magnesium levels for the total group of ill children were
admittedly enhanced, but in the youngest children, the levels were reduced.
The values of the Mg/Pb and Mg/Zn ratios were lower (in the youngest children, 70% decrease of the Mg/Pb ratio) and Zn/Cu
were higher in the group of children suffering from rheumatic diseases than in the healthy children. The difference of Mg/Pb
ratio between the total controls and rheumatic subjects was statistically significant at p<0.05 and the Zn/Cu at p<0.10. The Mg/Zn ratio was not statistically significant. 相似文献
19.
Iodine and zinc, but not selenium and copper, deficiency exists in a male Turkish population with endemic goiter 总被引:1,自引:0,他引:1
Metin Ozata Murat Salk Ahmet Aydin Savas Sayin Cagatay Oktenli Zeynel Beyham Askin Isimer I. Caglayan Ozdemir 《Biological trace element research》1999,69(3):211-216
Although endemic goiter has been shown to have a high prevalence in Turkey, little is known about the concentration of urinary
iodine, plasma selenium (Se), copper (Cu), and zinc (Zn) in these patients. We studied on 140 male patient with endemic goiter
(mean age: 22.2 ± 0.19 yr) and 140 healthy male subjects (mean age: 21.8 ± 0.28 yr). Daily urinary iodine excretion was determined
by the ionometric method. Plasma Se, Zn, and Cu were determined by using atomic absorption spectrometry. Daily urinary iodine
excretion was found to be significantly lower in the patient group (38.7 ± 2.26 μg/d) than that of controls (50.73 ± 2.56
μg/day,p = 0.001). Plasma Zn concentrations were also found to be significantly lower in the patient group (1.04 ± 0.03 μg/mL) than
that of controls (1.16 ± 0.02 μg/mL,p = 0.001). No significant difference was determined in Se and Cu concentrations between the patient and control groups. Our
study shows that a moderate iodine deficiency exists in both patients with endemic goiter and control subjects, which indicates
the important role of iodine deficiency in the etiopathogenesis of endemic goiter in Turkey. Zinc deficiency may also contribute
to the pathogenesis of endemic goiter. However, Se and Cu do not seem to have any role in the etiopathogenesis of endemic
goiter in Turkey. A community-based iodine fortification program throughout the country may be proposed to take over the problem,
which also can prevent the contributing effects of other element deficiencies that occur when iodine deficiency is the prevailing
factor. 相似文献
20.
Abdurrahim Kocyigit Ozcan Erel Mehmet S. Gurel Senel Avci Necmeddim Aktepe 《Biological trace element research》1998,65(3):271-281
The aim of this study was to measure the alterations in serum selenium (Se), copper (Cu), zinc (Zn), and iron (Fe) concentrations
and their carrier proteins, ceruloplasmin (Cp), transferrin (Tf) albumin, and related antioxidant enzyme activities, erythrocyte
Cu-Zn Superoxide dismutase (Cu-Zn SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities in patients with cutaneous
leishmaniasis (CL). Erythrocyte Cu-Zn SOD activities, serum Cu concentrations, and Cp levels were found to be significantly
higher in the patients group than those of controls. However, GSH-Px and CAT activities and Se, Zn, Fe, and Tf levels were
lower in patients than in the control subjects. There were positive important correlation’s between Cu-Zn SOD and Cp, Cu-Zn
SOD and Cu, Cp and Cu, GSH-Px and Se, and Fe and CAT in the patients group. Our results showed that serum essential trace
elements Se, Zn, Cu, and Fe concentrations and their related enzymes Cu-Zn SOD, GSH-Px, and CAT activities change in CL patients.
The changes may be a part of defense strategies of organism and are induced by the hormonelike substances. 相似文献