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Environment‐induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children 下载免费PDF全文
Matthias Bieg Zuguang Gu Dieter Weichenhan Jan‐Philipp Mallm Stefan Röder Gunda Herberth Eiko Takada Oliver Mücke Marcus Winter Kristin M Junge Konrad Grützmann Ulrike Rolle‐Kampczyk Qi Wang Christian Lawerenz Michael Borte Tobias Polte Matthias Schlesner Michaela Schanne Stefan Wiemann Christina Geörg Hendrik G Stunnenberg Christoph Plass Karsten Rippe Junichiro Mizuguchi Irina Lehmann 《Molecular systems biology》2016,12(3)
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Mutual antagonism between DNA methylation and H3K27me3 histone methylation suggests a dynamic crosstalk between these epigenetic marks that could help ensure correct gene expression programmes. Work from Manzo et al ( 2017 ) now shows that an isoform of de novo DNA methyltransferase DNMT3A provides specificity in the system by depositing DNA methylation at adjacent “shores” of hypomethylated bivalent CpG islands (CGI) in mouse embryonic stem cells (mESCs). DNMT3A1‐directed methylation appears to be instructive in maintaining the H3K27me3 profile at the hypomethylated bivalent CGI promoters of developmentally important genes. 相似文献
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