共查询到20条相似文献,搜索用时 15 毫秒
1.
Harri T Kiiveri 《BMC bioinformatics》2011,12(1):42
Background
Typical analysis of microarray data ignores the correlation between gene expression values. In this paper we present a model for microarray data which specifically allows for correlation between genes. As a result we combine gene network ideas with linear models and differential expression. 相似文献2.
Gabriela G Loots Patrick SG Chain Shalini Mabery Amy Rasley Emilio Garcia Ivan Ovcharenko 《BMC bioinformatics》2006,7(1):307-8
Background
There are several isolated tools for partial analysis of microarray expression data. To provide an integrative, easy-to-use and automated toolkit for the analysis of Affymetrix microarray expression data we have developed Array2BIO, an application that couples several analytical methods into a single web based utility. 相似文献3.
Background
The availability of high throughput methods for measurement of mRNA concentrations makes the reliability of conclusions drawn from the data and global quality control of samples and hybridization important issues. We address these issues by an information theoretic approach, applied to discretized expression values in replicated gene expression data. 相似文献4.
Birte Hellwig Jan G Hengstler Marcus Schmidt Mathias C Gehrmann Wiebke Schormann Jörg Rahnenführer 《BMC bioinformatics》2010,11(1):276
Background
A major goal of the analysis of high-dimensional RNA expression data from tumor tissue is to identify prognostic signatures for discriminating patient subgroups. For this purpose genome-wide identification of bimodally expressed genes from gene array data is relevant because distinguishability of high and low expression groups is easier compared to genes with unimodal expression distributions. 相似文献5.
Pamela A Nieto Paulo C Covarrubias Eugenia Jedlicki David S Holmes Raquel Quatrini 《BMC molecular biology》2009,10(1):63
Background
Normalization is a prerequisite for accurate real time PCR (qPCR) expression analysis and for the validation of microarray profiling data in microbial systems. The choice and use of reference genes that are stably expressed across samples, experimental conditions and designs is a key consideration for the accurate interpretation of gene expression data. 相似文献6.
Bruz Marzolf Eric W Deutsch Patrick Moss David Campbell Michael H Johnson Timothy Galitski 《BMC bioinformatics》2006,7(1):286-7
Background
The biological information in genomic expression data can be understood, and computationally extracted, in the context of systems of interacting molecules. The automation of this information extraction requires high throughput management and analysis of genomic expression data, and integration of these data with other data types. 相似文献7.
8.
Yao Yu Kang Tu Siyuan Zheng Yun Li Guohui Ding Jie Ping Pei Hao Yixue Li 《BMC bioinformatics》2009,10(1):264-7
Background
In the post-genomic era, the development of high-throughput gene expression detection technology provides huge amounts of experimental data, which challenges the traditional pipelines for data processing and analyzing in scientific researches. 相似文献9.
Background
A key step in the analysis of microarray expression profiling data is the identification of genes that display statistically significant changes in expression signals between two biological conditions. 相似文献10.
GW Patton R Stephens IA Sidorov X Xiao RA Lempicki DS Dimitrov RH Shoemaker G Tudor 《BMC bioinformatics》2006,7(1):81
Background
Microarrays used for gene expression studies yield large amounts of data. The processing of such data typically leads to lists of differentially-regulated genes. A common terminal data analysis step is to map pathways of potentially interrelated genes. 相似文献11.
12.
Background
The most fundamental task using gene expression data in clinical oncology is to classify tissue samples according to their gene expression levels. Compared with traditional pattern classifications, gene expression-based data classification is typically characterized by high dimensionality and small sample size, which make the task quite challenging. 相似文献13.
Evert-Jan Blom Sacha AFT van Hijum Klaas J Hofstede Remko Silvis Jos BTM Roerdink Oscar P Kuipers 《BMC bioinformatics》2008,9(1):535
Background
A typical step in the analysis of gene expression data is the determination of clusters of genes that exhibit similar expression patterns. Researchers are confronted with the seemingly arbitrary choice between numerous algorithms to perform cluster analysis. 相似文献14.
15.
Background
The increasing availability of time-series expression data opens up new possibilities to study functional linkages of genes. Present methods used to infer functional linkages between genes from expression data are mainly based on a point-to-point comparison. Change trends between consecutive time points in time-series data have been so far not well explored. 相似文献16.
Background
Time series microarray experiments are widely used to study dynamical biological processes. Due to the cost of microarray experiments, and also in some cases the limited availability of biological material, about 80% of microarray time series experiments are short (3–8 time points). Previously short time series gene expression data has been mainly analyzed using more general gene expression analysis tools not designed for the unique challenges and opportunities inherent in short time series gene expression data. 相似文献17.
Background
Survival time is an important clinical trait for many disease studies. Previous works have shown certain relationship between patients' gene expression profiles and survival time. However, due to the censoring effects of survival time and the high dimensionality of gene expression data, effective and unbiased selection of a gene expression signature to predict survival probabilities requires further study. 相似文献18.
19.