清栓酶治疗脑动脉硬化症80例疗效观察（摘要）

清栓酶治疗脑动脉硬化症８０例疗效观察（摘要）烟台市海阳荣军医院张维仕,车至英本文报告以清栓酶治疗脑动脉硬化症８０例,男６２例,女１８例,年龄４５～７０岁,其中合并高血压７例,风湿性心脏病４例。清栓酶常规治疗两疗程。结果显效率９６．３％,总有效率１００...     

清栓酶治疗脑梗塞90例疗效观察（摘要）

清栓酶治疗脑梗塞９０例疗效观察（摘要）解放军第１６８医院刘洪波,何造雄,邓诗梅,钱启颐本文报告用清栓酶治疗脑梗塞９０例,发病年龄平均６２岁,以清栓酶常规用药,结果痊愈４３例,显效１７例,有效２９例,无效１例,总有效率９８．８％。其中轻度６７例,痊愈４...     

清栓酶治疗过程中发生过敏反应1例报告

清栓酶治疗过程中发生过敏反应１例报告河北省沧州市中心医院中医科杜淑华吴某,女,５４岁,因患脑血栓,,于９０年９月入院。以５％葡萄糖氯化钠３００ｍｌ加入清栓酶０．７５ｕ稀释后静脉点滴,（清栓酶皮试阴性）用药２周后病情减轻,无任何不适,出院。于９１年１２...     

清栓酶的临床新用途

清栓酶的临床新用途吴青山近年来随着临床应用清栓酶的经验进一步积累,用途更为广泛,特作如下介绍：１．清栓酶治疗颅脑损伤综合征收治颅底骨折１例,脑震荡１５例。给予清栓酶０．７５单位加入５％葡萄糖氯化钠注射液５００毫升内静滴,每日一次,１４天为一疗程。治疗...     

蛇毒清栓酶治疗突发性耳聋48例疗效报告

本文报告用清栓酶治疗突聋48例的疗效观察。其中男40例,女8例,总有效率为88％。文章指出,病程越短,疗效越好,强调早期诊断,早期治疗。清栓酶与低分子右旋糖酐组治疗突聋进行了对比。清栓酶的疗效明显优于后者。清栓酶治疗突聋的机理是通过药物去纤、降粘、解聚、溶栓、扩血管,改善微循环等作用而实现的。清栓酶为治疗突聋的一种新方法,此药治疗作用迅速。效果可靠,无明显毒副作用,值得推广使用。     

清栓酶、维脑路通治疗缺血性脑梗塞30例临床疗效对比（摘要）

清栓酶、维脑路通治疗缺血性脑梗塞３０例临床疗效对比（摘要）天津市天和医院脑系科梁兴民河北省献县淮镇医院内科李向前本文报告清栓酶及维脑路通分别治疗脑血栓病各３０例,均为急性期。清栓酶常规用药,每日０．７５ｕ,维脑路通每日０．４克,均治疗２０天为一疗程。...     

清栓酶治疗系统性红斑狼疮46例疗效观察

清栓酶治疗系统性红斑狼疮４６例疗效观察陆军船艇学校朱雨生本人自１９９２年以来,采用清栓酶治疗系统性红斑狼疮４６例,取得了较满意的疗效,现报告如下。１临床资料本组４６例,其中男性９例,女性３７例;年龄１１－５８岁,平均年龄３３．２６岁;病程最短者４个月...     

清栓酶伍用消心痛治疗肺心病心衰30例疗效观察（摘要）

清栓酶伍用消心痛治疗肺心病心衰３０例疗效观察（摘要）武汉市第八人民医院内１科胡慧君本文报告应用清栓酶伍用消心痛治疗肺心病心衰３０例,并以常规药物治疗作对照２６例,消心痛每次服１０毫克,每日３次,清栓酶０．５ｕ加入１０％葡萄糖２５０～５００毫升中静滴,...     

清栓酶膀胱内注药致血尿1例

清栓酶膀胱内注药致血尿１例南京解放军３５０３厂医院熊汉璧清栓酶的临床应用日趋广泛,使用方法也多种多样,可全身血管内用药,也可局部用药腔内注射。作者曾使用清栓酶膀胱内注射引起全程血尿１例,特报导望引起同道注意。患者李××,男,８２岁,因慢支咳喘入院,有...     

对70例急性心肌梗塞行清栓酶静脉给药的溶栓效果分析

用清栓酶静脉给药对７０例急性心肌梗塞病人持续进行２４ｈ溶栓疗法,再通率为８８．５７％;发病６ｈ内接受溶栓者,再通率为９３．９％,发病１２ｈ～２４ｈ接受溶栓者,再通率为３３．３％,二者有显著性差异（Ｐ＜０．０５）;阐述了清栓酶溶栓的疗效机理,认为这是目前最理想的溶栓剂     

DNA synthesis in vivo in Bacillus subtilis

DNA polymerase III is the enzyme responsible for deoxynucleotide addition to nascent DNA fragments in Bacillus subtilis protoplasts. Nascent single-stranded fragments separated from bulk DNA by hydroxyapatite chromatography cannot self-anneal. Partial inhibition of DNA polymerase III by 6-(hydroxyphenylazo)-uracil, a specific inhibitor, slows the rate of nascent fragment synthesis but has no effect on final size. Neither DNA polymerase I nor II can elongate nascent fragments in protoplasts when DNA polymerase III is completely inhibited.     

Alterations in central and peripheral adrenergic receptors in deoxycorticosterone/salt hypertensive rats

The treatment of uninephrectomized rats with deoxycorticosterone (DOCA) and salt for 6 weeks caused a significant systolic hypertension and cardiac and renal hypertrophy. There was a significant decrease in the density of cardiac α₁- and β-, and renal α₁-adrenoceptors in DOCA/salt hypertensive rats, as compared to uninephrectomized salt loaded control rats. In contrast, the cerebral cortex, corpus striatum, hippocampus and hypothalamus/thalamus of hypertensive rats showed a significant increase in adrenoceptor binding in these hypertensive rats. In contrast, muscarinic cholinergic receptors and [³H]yohimbine binding sites were not altered in most tissues of the hypertensive rats. The present study suggests an important role for central and peripheral α₁- and β-adrenoceptors in the pathogenesis of hypertension.     

Opioid receptor agonists in the rabbit colon: comparison of in vivo and in vitro studies

Myoelectrical activity was recorded in the proximal and distal colon of rabbits using chronically implanted electrodes. The motility in both the proximal and distal colon was inhibited by the intravenous (IV) administration of the following opioid agonists for mu receptors: morphine and fentanyl, kappa receptors: ethylketazocine (EKC) and U 50 488 H, and delta receptors: D-Ala2 D-Leu5-enkephalin (DADLE) and D-Ser2 Leu-enkephalin-Thr6 (DSLET). In contrast, the myoelectric activity in the distal colon was increased during the infusion of an endogenous kappa opioid agonist, dynorphin (DYN). All of these effects were prevented by naloxone pretreatment. During in vitro studies using extraluminal force transducers, fentanyl, U 50 488 H and DSLET inhibited spontaneous contractions of the proximal colon, but U 50 488 H and DSLET caused a substantial increase in the motility of the distal colon. The observed motor responses in the proximal and distal colon following opioid agonist administration indicate that the control of these two intestinal segments may be different. It is suggested that the stimulatory effect of dynorphin on the distal colon is peripherally-mediated while inhibition of the whole colon by opioid agonists regardless of subtypes seems to be centrally-mediated.     

Photosynthesis research in India: transition from yield physiology into molecular biology

Photosynthesis research in India can be traced back several thousand years, with the mention of the Sun energizing the plants, which form food for all living creatures on the earth (from the Mahabharata, the great epic, ca. 2600 B.C.) and the report of Sage Parasara (ca. 100 B.C.) on the ability of plants to make their own food, due to their pigments. With the pioneering studies by Sir Jagdish Chandra Bose, work on photosynthesis proceeded steadily during the first half of the 20th century. Some of the classic reports during this period are: malate metabolism in Hydrilla, spectrophotometric estimation of chlorophylls, importance of spectral quality for photosynthesis – an indication of two photosystems, photoinactivation of photosynthesis, and importance of flag leaf photosynthesis to grain yield. After the 1960s, there was a burst of research in the areas of physiology and biochemistry of carbon assimilation and photochemistry. A significant transition occurred, before the beginning of new millennium, into the area of molecular biology of chloroplasts, regulation of photosynthesis and stress tolerance. Future research work in India is geared to focus on the following aspects of photosynthesis: elucidation/analysis of genes, molecular biology/evolution of enzymes, development/use of transgenics and modeling. This revised version was published online in August 2006 with corrections to the Cover Date.     

Endocytosis in Chinese hamster fibroblasts : Inhibition by glucose

Endocytosis in Chinese hamster ovary fibroblasts was investigated by measuring the rate of uptake of ³H-sucrose, which is known to enter cells only by endocytosis. Serum, polyvinylpyrrolidone (PVP), adenosine triphosphate, insulin, and cyclic 3′,5′-adenosine monophosphate, all of which are known to increase the rate of endocytosis by other cell systems, had no effect on Chinese hamster fibroblasts. However, medium in which these cells had been maintained for several days, referred to as conditioned medium, had a profound effect on endocytosis. These cells endocytosed 3 to 5 times as rapidly in conditioned medium as in fresh medium. A logarithmic inhibition of this effect was observed with increasing -glucose concentrations, however, glucose-free medium did not produce as great an effect as conditioned medium. This suggests that these cells may endocytose in response to their nutritional requirements.     

Counts and characteristics of macrophage precursors in human peripheral blood.

A method is described for counting the number of macrophages which develop from a sample of human venous blood. Because the macrophages are nondividing cells under these conditions of culture, it is possible to use the count to describe the size of a population of macrophage precursors in the blood. Counts on 43 healthy individuals show that on average there are some 200,000/ml of blood, which is 5–6% of the total white cell count. The precursor cells are mononuclear and the majority of them will adhere to plastic. These characteristics suggest that monocytes are the precursor cells.     

Diurnal variations in learning performance in chickens

Diurnal variations in the learning performance of young chicks were investigated using a visual discrimination task which requires birds to discrminate grains from a background of pebbles. Chicks accustomed to receiving fresh food daily in the morning were found to learn well during the day, in that they pecked almost exclusively at grains; but during the night they pecked indiscriminately at grains and pebbles. This occurred even though food was available ad libitum. Chicks accustomed to receiving fresh food daily in the evening learnt the task during the day, and also late at night. Thus the shape of the performance cycle depends in part on environmental factors. Other factors, such as activity, which may contribute to, or co-vary with, this variation in learning performance were investigated.