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海参生物活性研究进展 总被引:3,自引:0,他引:3
海参是重要的海洋食物和药物资源,含有多种生物活性成分,如多糖、皂苷、多肽及蛋白质和脂类等其他活性成分,具有增强免疫力、抗凝血、镇痛、抗肿瘤、抗真菌、抗病毒、抗衰老和抗疲劳等生理功能.本文简要介绍了我国海参资源的分布情况,综述了国内外对海参生物活性物质组成及其药理作用研究的新进展.旨在为科学工作者对海参展开细胞和分子水平上的研究、寻找新型的海洋高效药物和功能性食品的开发提供参考,同时为我国丰富的海参资源的开发利用提供新思路. 相似文献
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综述瑞香素的生物活性研究进展。药理研究证实其有抗炎、抑菌、抗血栓、抗凝等作用,在临床上也极具有广泛的应用前景。 相似文献
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超氧化物歧化酶模拟化合物的生物活性研究 总被引:16,自引:0,他引:16
根据天然超氧化物歧化酶(SOD)活性部位结构合成了含苯并咪唑的5种配体及其32种分别含Cu(Ⅱ)、Fe(Ⅲ)、Mn(Ⅱ)、Co(Ⅱ)的模拟化合物.经光谱、电化学测试证明这些化合物具有拟S3D活性,其50%抑制率浓度(IC50)为10-6~10-8mol·L-1,催化超氧离子自由基(O-·2)歧化的反应速率常数kq为106~108mol-1·L·s-1.同时观察到几种模拟化合物有抗肿瘤活性或增强水稻抗寒性. 相似文献
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褐藻胶寡糖生物活性研究进展 总被引:1,自引:0,他引:1
褐藻寡糖AOS由β-D-甘露糖醛酸(ManA)和α-L-古洛糖醛酸(GulA)通过1-4糖苷键连接而成,具有广泛的生物活性,如促进植物生长、缓解植物非生物胁迫、抗肿瘤、抑菌等作用,在绿色农业、医药保健等领域具有广阔的前景。本文综述了近几年来褐藻胶寡糖在生物活性方面的研究进展,并对其应用前景进行了展望。 相似文献
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神经节苷脂的生物学活性 总被引:7,自引:0,他引:7
神经节苷脂(ganglioside, GS)是一类含唾液酸的糖鞘脂,广泛存在于脊椎动物各组织细胞膜上,尤其在胎儿和新生儿的脑中高浓度存在,因此被认为与神经细胞的分化、神经树突的伸长、突触的形成有重要关系,较早的研究就已发现外源性施加神经节苷脂可以促进神经系统的再生和突触的形成.随着合成技术和分子生物学技术的进步,发现神经节苷脂不仅与神经系统的发育、老年痴呆、帕金森症等神经退行性疾患有密切关系,而且与肿瘤的发病过程也有一定的联系,由此受到广泛关注.本文结合本实验室的研究工作,对近年国际上对神经节苷脂在生物学活性方面的研究进展,从突触可塑性、神经退行性疾病、肿瘤三方面予以综述. 相似文献
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Pregnane glycosides are exist in Asclepiadaceae, Apocynaceae, Malpighiaceae, Ranunculaceae and Zygophyllaceae. This is a class of substances with steroids as the mother nucleus and containing a glyosidic bond structure. Modern pharmacology has shown that these compounds are a class of compounds with different structures and multiple biological activities. It has a good development prospect in anti-cancer and anti-tumor directions. This article reviews the chemical structures and biological activities of 345 compounds from 1984 to 2019. 相似文献
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双歧杆菌脂磷壁酸生物学活性研究进展 总被引:1,自引:0,他引:1
本文综述了双歧杆菌脂磷壁酸(lipoteichoic acid,LTA)的免疫激活、抗肿瘤、抗突变、抗衰老及粘附等重要生物学功能。 相似文献
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悬钩子属植物生物学作用研究进展 总被引:5,自引:0,他引:5
悬钩子属(Rubus)植物是蔷薇科(Rosaceae)中的一个大属,全世界已知有750余种,我国约有210多种,分布广泛,但以长江以南及西北地区多见。本属植物中有些种类果实柔嫩多汁,营养丰富;有些种类的果实、种子、根及叶可入药,药用价值较高,具活血化瘀,祛风祛湿,清热解毒,止血止痛,固肾涩精等功效。20世纪80年代以来,我国覆盆子研究利用引起了人们的关注。就近年来悬钩子属植物生物学作用研究情况作一总结。 相似文献
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Saburo Takei Yuzo Inouye Minoru Ohno Sankichi Takei 《Bioscience, biotechnology, and biochemistry》2013,77(6):362-366
The separation of (±) -2,2-dimethyl-3- (3′,4′-methylenedioxyphenyl) -cyclopropane-1-carboxylic acid into the geometrical isomers and the assignment of their configurations were achieved. Of the two isomers, the (±) -trans-acid, which was found more toxic when esterified with (±) -allethrolone, was resolved by means of an optically active α-phenylethylamine salt into (+) - and (-) -enantiomers. (IR:3R) -Configuration was assigned to the (+) -trans-acid and (IS:3S) -configuration to the (-) -trans-acid. The bioassay revealed that the (±) -allethrolone ester with the (+) -trans-acid, which belongs to the same optical series as the natural chrysanthemum acids, was the most toxic against common houseflies, as was the case with other pyrethroids. 相似文献
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咖啡为茜草科(Rubiaceae)咖啡属(Coffea)植物,位居世界三大饮品之首,具有降低血糖、保护肝脏和神经保护等作用.咖啡化学成分类别较多,包括生物碱、酚酸类、黄酮类、萜类等.咖啡中的化学成分是发挥其生物学功能和形成特色风味的基础,对其化学成分来源和生物活性进行综述,为进一步发展咖啡产业提供依据和理论支撑. 相似文献
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Some new allethronyl esters of cyclopropanecarboxylic acids were prepared, and their insecticidal activities were tested against common housefly. Allethronyl esters of cyclopropanecarboxylic acids having 3,4-methylenedioxyphenyl group on the cyclopropane ring were more or less toxic. Among them, allethronyl 2,2-dimethyl-3-(3′,4′-methylenedioxyphenyl)-cycloopropane-l-carboxylate was found to be more toxic than α-dl-trans-allethrin, and the calculated relative effectiveness were 1.48 and 1.21 on the mortality and knock-down activity respectively as compared with α-dl-trans-allethrin. 相似文献
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Lignans, which are widely distributed in higher plants, represent a vast and rather diverse group of phenylpropane derivatives. They have attracted considerable attention due to their pharmacological activities. Some of the lignans have been developed approved therapeutics, and others are considered as lead structures for new drugs. This article is based on our previous review of lignans discovered in the period 2000–2004, and it provides a comprehensive compilation of the 354 new naturally occurring lignans obtained from 61 plant families between 2005 and 2011. We classified five main types according to their structural features, and provided the details of their sources, some typical structures, and diverse biological activities. A tabular compilation of the novel lignans by species is presented at the end. A total of 144 references were considered for this review. 相似文献
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Rachel Haynes 《Biotechnic & histochemistry》1928,3(4):131-139
The effect of buffer solutions of varying reaction upon staining fixed sections with thionin, azures A, B, and C, and methylene blue has been studied. The buffer solutions were employed in one of three different ways: for pre-treatment of the sections, for post-treatment, or as solvents for the dyes. Regardless of the method of employing the buffer solutions it was found that the intensity of staining increased with increasing pH-values (a fact which is generally known to be true in the case of basic dyes). It is not certain whether this effect is due to varying the H-ion concentration or to altering the salt content of the solution, or to both. It was also noticed that there was one point where the staining intensify increased most rapidly. This point was either between pH 5 and pH 6 or between pH 6 and pH 7, its position varying with the method of fixation and of applying the buffer solutions. It was further observed that between pH 5 and pH 7 there were always more pronounced metachromatic effects than with either more acid or more alkaline buffer solutions. 相似文献