共查询到20条相似文献,搜索用时 187 毫秒
1.
De Rooy DP Willemze A Mertens B Huizinga TW Van der Helm-van Mil AH 《Arthritis research & therapy》2011,13(5):R180
Introduction
Studies investigating genetic risk factors for susceptibility to rheumatoid arthritis (RA) studied anti-citrullinated peptide antibody (CCP)-positive RA more frequently than anti-CCP-negative RA. One of the reasons for this is the perception that anti-CCP-negative RA may include patients that fulfilled criteria for RA but belong to a wide range of diagnoses. We aimed to evaluate the validity of this notion and explored whether clinical subphenotypes can be discerned within anti-CCP-negative RA. 相似文献2.
Alejandro Balsa Arancha Cabezón Gisela Orozco Tatiana Cobo Eugenia Miranda-Carus Miguel Ángel López-Nevot José Luis Vicario Emilio Martín-Mola Javier Martín Dora Pascual-Salcedo 《Arthritis research & therapy》2010,12(2):R62
Introduction
The purpose of this study was to investigate the association between HLA-DRB1 alleles with susceptibility to rheumatoid arthritis (RA) and production of antibodies against citrullinated proteins (ACPA) and rheumatoid factor (RF). 相似文献3.
Zhao X Okeke NL Sharpe O Batliwalla FM Lee AT Ho PP Tomooka BH Gregersen PK Robinson WH 《Arthritis research & therapy》2008,10(4):R94
Introduction
There is increasing evidence that autoantibodies and immune complexes (ICs) contribute to synovitis in rheumatoid arthritis (RA), yet the autoantigens incorporated in ICs in RA remain incompletely characterised. 相似文献4.
Syversen SW Goll GL Haavardsholm EA Bøyesen P Lea T Kvien TK 《Arthritis research & therapy》2008,10(2):R28
Introduction
Prognosis in rheumatoid arthritis (RA) is difficult to assess. The aim of this study was to examine whether serum levels of a spectrum of cytokines were predictive of radiographic progression in early RA patients. 相似文献5.
Vincent Goëb Marlène Thomas-L'Otellier Romain Daveau Roland Charlionet Patrice Fardellone Xavier Le Loët François Tron Danièle Gilbert Olivier Vittecoq 《Arthritis research & therapy》2009,11(2):R38-14
Introduction
The aim of our study was to identify new early rheumatoid arthritis (RA) autoantibodies. 相似文献6.
Pascale Nicaise Roland Sabine Grootenboer Mignot Alessandra Bruns Margarita Hurtado Elisabeth Palazzo Gilles Hayem Philippe Dieudé Olivier Meyer Sylvie Chollet Martin 《Arthritis research & therapy》2008,10(6):R142
Introduction
Antibodies against cyclic citrullinated peptides (CCPs) are useful for diagnosing rheumatoid arthritis (RA). Antibodies to mutated citrullinated vimentin (MCV) were described recently in RA. The aims of this study were to evaluate the usefulness of anti-MCV for diagnosing RA in anti-CCP-negative patients and to monitor anti-MCV titres during infliximab therapy for RA. 相似文献7.
Introduction
Many people with rheumatoid arthritis (RA) do not receive care from a rheumatologist. We surveyed primary care physicians (PCPs) to better understand their attitudes, knowledge, and practices regarding the optimal treatment of RA. 相似文献8.
Ann-Charlotte Elkan Niclas Håkansson Johan Frostegård Tommy Cederholm Ingiäld Hafström 《Arthritis research & therapy》2009,11(2):R37-11
Introduction
Patients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease (CVD) independent of traditional risk factors. The aim of this study was to analyze the associations between diet, body composition, lipids and atheroprotective natural antibodies against phosphorylcholine (anti-PC) in patients with RA. 相似文献9.
Bianca Miterski Susanne Drynda Gundula B?schow Wolfram Klein Joachim Oppermann J?rn Kekow J?rg Thomas Epplen 《BMC genetics》2004,5(1):2
Background
Rheumatoid arthritis (RA) and juvenile rheumatoid arthritis (JRA) are complex multifactorial diseases caused by environmental influences and an unknown number of predisposing genes. The present study was undertaken in order to investigate association of polymorphisms in candidate genes with RA and JRA in German subjects. 相似文献10.
Yvonne C Lee Lori B Chibnik Bing Lu Ajay D Wasan Robert R Edwards Anne H Fossel Simon M Helfgott Daniel H Solomon Daniel J Clauw Elizabeth W Karlson 《Arthritis research & therapy》2009,11(5):R160
Introduction
Despite recent advances in anti-inflammatory therapy, rheumatoid arthritis (RA) patients continue to rate pain as a priority. The etiology of RA pain is likely multifactorial, including both inflammatory and non-inflammatory components. In this study, we examine the association between disease activity, sleep, psychiatric distress and pain sensitivity in RA. 相似文献11.
Madsen RK Lundstedt T Gabrielsson J Sennbro CJ Alenius GM Moritz T Rantapää-Dahlqvist S Trygg J 《Arthritis research & therapy》2011,13(1):R19
Introduction
The aim of this study was to assess the feasibility of diagnosing early rheumatoid arthritis (RA) by measuring selected metabolic biomarkers. 相似文献12.
Introduction
Infection is a major cause of morbidity and mortality in patients with rheumatoid arthritis (RA). The objective of this study was to perform a systematic review and meta-analysis of the effect of glucocorticoid (GC) therapy on the risk of infection in patients with RA. 相似文献13.
Van Doornum S Brand C Sundararajan V Ajani AE Wicks IP 《Arthritis research & therapy》2010,12(5):R183
Introduction
The 30-day case-fatality rate after acute myocardial infarction (MI) for rheumatoid arthritis (RA) patients is twice that of the general population. This study compared the frequency and timeliness of early reperfusion therapy and treatment with secondary prevention medications after acute MI in RA patients and controls. 相似文献14.
Introduction
Macrophage migration inhibitory factor (MIF) is one of key regulators in acute and chronic immune-inflammatory conditions including rheumatoid arthritis (RA). We examined the effect of MIF on osteoclastogenesis, which is known to play a crucial role in bone destruction in RA. 相似文献15.
Vanina Jodon de Villeroché Jérome Avouac Aurélie Ponceau Barbara Ruiz André Kahan Catherine Boileau Georges Uzan Yannick Allanore 《Arthritis research & therapy》2010,12(1):R27
Introduction
Angiogenesis and vasculogenesis are critical in rheumatoid arthritis (RA) as they could be a key issue for chronic synovitis. Contradictory results have been published regarding circulating endothelial progenitor cells (EPCs) in RA. We herein investigated late outgrowth EPC sub-population using recent recommendations in patients with RA and healthy controls. 相似文献16.
Kim SY Servi A Polinski JM Mogun H Weinblatt ME Katz JN Solomon DH 《Arthritis research & therapy》2011,13(1):R32
Introduction
Health care utilization databases have been increasingly used for studies of rheumatoid arthritis (RA). However, the accuracy of RA diagnoses in these data has been inconsistent. 相似文献17.
Franziska Renger Holger Bang Eugen Feist Gert Fredenhagen Alexander Natusch Marina Backhaus Gerd-R Burmester Karl Egerer 《Arthritis research & therapy》2010,12(3):R120
Introduction
Autoantibodies against mutated and citrullinated vimentin (MCV) represent a novel diagnostic marker for rheumatoid arthritis (RA). Recently, an increased sensitivity for anti-MCV compared to autoantibodies against cyclic citrullinated peptides (anti-CCP2) was shown in cohorts of patients with early RA and established disease. 相似文献18.
Jeffrey H Ruth Christy C Park M Asif Amin Charles Lesch Hubert Marotte Shiva Shahrara Alisa E Koch 《Arthritis research & therapy》2010,12(3):R118
Introduction
The function of interleukin-18 (IL-18) was investigated in pertinent animal models of rodent rheumatoid arthritis (RA) to determine its proinflammatory and monocyte recruitment properties. 相似文献19.
Wei Zhang Nick Bansback Annelies Boonen Adam Young Amitabh Singh Aslam H Anis 《Arthritis research & therapy》2010,12(5):R177
Introduction
The Work Productivity and Activity Impairment (WPAI) questionnaire is a well validated instrument to measure impairments in work and activities. However, its validation among patients with rheumatoid arthritis (RA) has not been well established. The present study's purpose is to evaluate the construct validity of the WPAI-general health version among RA patients and its ability to differentiate between RA patients with varying health status. 相似文献20.
Manathip Osiri Jeerapat Wongchinsri Sitthichai Ukritchon Punchong Hanvivadhanakul Nuntana Kasitanon Boonjing Siripaitoon 《Arthritis research & therapy》2009,11(4):R129-8