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Novel transcription map for the B19 (human) pathogenic parvovirus 总被引:15,自引:15,他引:15
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A putative nucleoside triphosphate-binding domain in the nonstructural protein of B19 parvovirus is required for cytotoxicity. 总被引:2,自引:5,他引:2 下载免费PDF全文
Cytotoxicity secondary to B19 parvovirus infection is due to expression of the viral nonstructural protein. Nonstructural proteins of many parvoviruses contain a well-conserved nucleoside triphosphate (NTP)-binding motif, which has been shown to be essential for a variety of protein functions. We show here that cytotoxicity of the B19 parvovirus nonstructural protein was abolished by single mutations of amino acids within the NTP-binding domain, especially within the A motif, implicating NTP-binding in virus-induced cell death. 相似文献
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Bor-Show Tzang Chun-Ching Chiu Chun-Chou Tsai Yi-Ju Lee I-Jung Lu Jing-Yu Shi Tsai-Ching Hsu 《Journal of biomedical science》2009,16(1):13-9
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Activity of secreted phospholipase A (sPLA2) has been implicated in a wide range of cellular responses. However, little is known about the function of human parvovirus B19-VP1 unique region (VP1u) with sPLA2 activity on macrophage. 相似文献14.
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