TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains

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Branching via K11 and K48 Bestows Ubiquitin Chains with a Unique Interdomain Interface and Enhanced Affinity for Proteasomal Subunit Rpn1

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Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase

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Cryo-EM Reveals Unanchored M1-Ubiquitin Chain Binding at hRpn11 of the 26S Proteasome

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K63-linked ubiquitin chains are a global signal for endocytosis and contribute to selective autophagy in plants

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Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition

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The Cdc48 N-terminal domain has a molecular switch that mediates the Npl4-Ufd1-Cdc48 complex formation

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APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain

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Orphan quality control shapes network dynamics and gene expression

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Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216

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Co-adaptor driven assembly of a CUL3 E3 ligase complex

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Cullin-independent recognition of HHARI substrates by a dynamic RBR catalytic domain

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A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis

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Structural basis for the interaction between human Npl4 and Npl4-binding motif of human Ufd1

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The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway

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H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

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The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia

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Phosphorylation at Ser65 modulates ubiquitin conformational dynamics

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Ubiquitination of phosphatidylethanolamine in organellar membranes

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Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1

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