HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases

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Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

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Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis

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PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

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Toll receptors remodel epithelia by directing planar-polarized Src and PI3K activity

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KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice

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Exosomal miR-27b-3p secreted by visceral adipocytes contributes to endothelial inflammation and atherogenesis

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APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin

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m6A-driven SF3B1 translation control steers splicing to direct genome integrity and leukemogenesis

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Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos

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The Mettl3 epitranscriptomic writer amplifies p53 stress responses

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Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity

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Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development

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Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study

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TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation

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Spatiotemporal control of ERK pulse frequency coordinates fate decisions during mammary acinar morphogenesis

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Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response

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Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover

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Structure of the human UBR5 E3 ubiquitin ligase

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Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis,transitions between metabolic states,and their regulatory mechanisms

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