Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease

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Functional map of SARS-CoV-2 3CL protease reveals tolerant and immutable sites

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Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing

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Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax

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Reduced peroxisomal import triggers peroxisomal retrograde signaling

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Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

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Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation

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Decoding the Functional Evolution of an Intramembrane Protease Superfamily by Statistical Coupling Analysis

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Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation

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Aryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes

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Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2

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SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

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Evolutionary plasticity in the requirement for force exerted by ligand endocytosis to activate C. elegans Notch proteins

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The genetic architecture of pediatric cardiomyopathy

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Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease

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SUMO Conjugation to BZR1 Enables Brassinosteroid Signaling to Integrate Environmental Cues to Shape Plant Growth

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A genome sequencing system for universal newborn screening,diagnosis, and precision medicine for severe genetic diseases

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Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging

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Trans-ethnic variation in germline variants of patients with renal cell carcinoma

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