共查询到20条相似文献,搜索用时 31 毫秒
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Mathew A Mathur SK Jolly C Fox SG Kim S Morimoto RI 《Molecular and cellular biology》2001,21(21):7163-7171
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Shinkawa T Tan K Fujimoto M Hayashida N Yamamoto K Takaki E Takii R Prakasam R Inouye S Mezger V Nakai A 《Molecular biology of the cell》2011,22(19):3571-3583
Heat shock response is characterized by the induction of heat shock proteins (HSPs), which facilitate protein folding, and non-HSP proteins with diverse functions, including protein degradation, and is regulated by heat shock factors (HSFs). HSF1 is a master regulator of HSP expression during heat shock in mammals, as is HSF3 in avians. HSF2 plays roles in development of the brain and reproductive organs. However, the fundamental roles of HSF2 in vertebrate cells have not been identified. Here we find that vertebrate HSF2 is activated during heat shock in the physiological range. HSF2 deficiency reduces threshold for chicken HSF3 or mouse HSF1 activation, resulting in increased HSP expression during mild heat shock. HSF2-null cells are more sensitive to sustained mild heat shock than wild-type cells, associated with the accumulation of ubiquitylated misfolded proteins. Furthermore, loss of HSF2 function increases the accumulation of aggregated polyglutamine protein and shortens the lifespan of R6/2 Huntington's disease mice, partly through αB-crystallin expression. These results identify HSF2 as a major regulator of proteostasis capacity against febrile-range thermal stress and suggest that HSF2 could be a promising therapeutic target for protein-misfolding diseases. 相似文献
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Tanikawa J Ichikawa-Iwata E Kanei-Ishii C Nakai A Matsuzawa S Reed JC Ishii S 《The Journal of biological chemistry》2000,275(20):15578-15585
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HSF4 is required for normal cell growth and differentiation during mouse lens development 总被引:8,自引:0,他引:8
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Fujimoto M Izu H Seki K Fukuda K Nishida T Yamada S Kato K Yonemura S Inouye S Nakai A 《The EMBO journal》2004,23(21):4297-4306
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Activation of heat shock genes is not necessary for protection by heat shock transcription factor 1 against cell death due to a single exposure to high temperatures
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Inouye S Katsuki K Izu H Fujimoto M Sugahara K Yamada S Shinkai Y Oka Y Katoh Y Nakai A 《Molecular and cellular biology》2003,23(16):5882-5895
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