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1.
《Molecular & cellular proteomics : MCP》2019,18(1):151-161
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- •New MALDI MS imaging sample preparation workflow reveals tissue protease activity.
- •Differential time- and inhibitor concentration-dependence confirm active proteases.
- •Mouse gastric tumor displays high protease activity compared to surrounding tissue.
- •Proteomic data and biochemical protease activity assay support MALDI MSI results.
2.
Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation*
《Molecular & cellular proteomics : MCP》2019,18(5):909-922
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- •Characterization of the phagosomal proteome comparing resting and LPS-treated BMDCs.
- •Label-free quantification determined 2843 phagosomal proteins.
- •Reduced recruitment of hydrolases and V-ATPase to phagosomes of LPS-treated cells.
- •Increased recruitment of antigen cross-presentation molecules to these phagosomes.
3.
《Molecular & cellular proteomics : MCP》2019,18(5):854-864
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- •Zero-length chemical cross-linking of APOA1 peptides in HDL.
- •Cross-links match antiparallel isomers of APOA dimers in molecular modeling.
- •Identical MS/MS spectra of native and synthetic cross-linked peptides.
- •First biochemical evidence of LL5/5 and LL5/4 isomers in human HDL.
4.
《Molecular & cellular proteomics : MCP》2019,18(5):936-953
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- •In-depth proteome profiling of primary human myeloma cells
- •Characteristics of myeloma cells are related to hypoxic bone marrow conditions
- •Myeloma cells show specific immune evasion strategies
- •Metabolic adaptations involve tumor and stroma cells
5.
《Molecular & cellular proteomics : MCP》2019,18(6):1110-1122
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- •Comprehensive analysis of inter-individual variation of normal urinary proteome.
- •Significant gender differences were observed.
- •Proteins increased in female urine are enriched in immunological pathways.
- •Estimated reference intervals of proteins as the baseline for biomarker discovery.
6.
《Molecular & cellular proteomics : MCP》2019,18(2):320-337
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- •Hsp70 homologs differ in their oligomeric properties in the presence of ATP.
- •Human inducible Hsp70 forms ATP-dependent anti-parallel dimers with high propensity.
- •Dimerization of ATP-bound Hsp70 is required for effective Hsp70-Hsp40 interaction.
- •ATP-dependent interaction with Tomm34 TPR cochaperone disrupts Hsp70 dimer.
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8.
《Molecular & cellular proteomics : MCP》2019,18(8):1479-1490
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- •Frequent genetic polymorphism affects the glycosylation pattern of fetuin.
- •Personalized in-depth proteoform profiling of fetuin purified from 20 donors.
- •Classification of serum donors into three different genotypes.
- •Septic patients show increased level of fucosylation at N-glycolation site N176.
9.
《Molecular & cellular proteomics : MCP》2019,18(11):2324-2334
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- •Automated analysis of protein complexes in proteomic experiments.
- •Quantitative measurement of the coordinated changes in protein complex components.
- •Interactive visualizations for exploratory analysis of proteomic results.
10.
《Molecular & cellular proteomics : MCP》2018,17(12):2448-2461
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- •Chemical proteomics strategy for quantitative profiling of phosphoprotein phosphatases.
- •Compatible with quantitative multiplexing approaches.
- •Applicable to many samples types including tissues from human to yeast.
11.
《Molecular & cellular proteomics : MCP》2019,18(5):982-994
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- •MaxQuant.Live controls Orbitrap mass analyzers in real-time.
- •Freely available apps enable advanced data acquisition strategies.
- •On-the-fly mass, retention time and intensity recalibration.
- •Global targeting unifies shotgun and targeted proteomics.
12.
《Molecular & cellular proteomics : MCP》2019,18(4):786-795
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- •Quantitative cross-linking mass spectrometry (QCLMS) was automated by Spectronaut.
- •Data-independent acquisition (DIA) was adapted to QCLMS.
- •Accuracy and precision of quantitation improves with DIA over DDA.
- •QCLMS is now ready for use in complex samples.
13.
《Molecular & cellular proteomics : MCP》2019,18(8):1556-1571
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- •Functional role of a yet uncharacterized receptor kinase QSK1.
- •Activation model for SIRK1 receptor kinase in a heteromer with QSK1.
- •Role of QSK1 in substrate recruitment and stabilization of the complex.
14.
《Molecular & cellular proteomics : MCP》2018,17(11):2119-2131
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- •Temporal proteome profiling of lipotoxicity and glucolipotoxicity in β-cells
- •Palmitate induced cholesterol metabolism earlier than fatty acid metabolism
- •Setd8 promotes palmitate + glucose-stimulated INS-1 cell proliferation
- •PA induced apoptosis partially via upregulation of Rhob in INS-1 cells
15.
《Molecular & cellular proteomics : MCP》2019,18(2):231-244
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- •OMICS distinguish cancer cells from resistant or cancer stem cells.
- •Bactericidal antibiotics and mitochondria.
- •Linezolid and anticancer therapy.
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17.
《Molecular & cellular proteomics : MCP》2019,18(10):2089-2098
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- •Cathepsin-L is introduced as a novel protease for HX-MS studies.
- •Cathepsin-L improves resolution of traditionally challenging histone tails.
- •Cathepsin-L can be readily combined with pepsin for improved protein coverage.
- •In-solution dynamics of the H3.1 and H4 monomers reveal extensive EX1 kinetics.
18.
《Molecular & cellular proteomics : MCP》2019,18(8):1669-1682
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- •Spatiotemporal microproteomics analysis of TBI.
- •Injury site microproteomics reveal distinct phases in 10-day frame post TBI.
- •Uninjured proteomic profile is restored in TBI at 10 days post injury.
- •Substantia nigra protein post 3 days suggest link to Parkinson's disease.
19.
《Molecular & cellular proteomics : MCP》2018,17(12):2371-2386
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- •Stability of oxidative phosphorylation subunits are reduced in a diet-induced mouse model of NAFLD.
- •These changes are associated with impaired activities of electron transport chain complexes and ATP synthesis.
- •Increased mitophagy contributed to enhanced degradation of mitochondrial proteins.
20.
《Molecular & cellular proteomics : MCP》2019,18(2):245-262
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- •AP-DIA/SWATH analysis to identify TCTP-interacting proteins in NF1 tumor cells.
- •A highly specific TCTP–EF1A2 interaction but rather than TCTP–EF1A1 interaction.
- •TCTP–EF1A2 interaction mediating formation of EF1A2-elogation factor complex.
- •TCTP–EF1A2 dependent translation machinery regulating NF1 tumor cell growth.