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1.
《Molecular & cellular proteomics : MCP》2019,18(10):2078-2088
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- •Proteomic landscapes of Drosophila somatic and reproductive tissues during aging.
- •Pulsed metabolic labeling determines a decline in protein synthesis with age.
- •Drosophila model of human Parkinson's disease signifies an early-onset decline in protein synthesis.
- •Collapse of proteostasis and mitochondria are early signals for normal aging.
2.
《Molecular & cellular proteomics : MCP》2019,18(4):669-685
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- •quantitative phosphoproteome analysis of TDM-activated macrophages.
- •distinct Mincle-dependent and independent phosphorylation and gene regulations.
- •Mincle-dependent activation of PI3K/AKT signaling by TDM.
- •Mincle-independent macrophage response is linked to cell cycle regulation.
3.
《Molecular & cellular proteomics : MCP》2018,17(11):2146-2163
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- •Construction of threespine stickleback gill assay library using DDA proteomics
- •Population-specific gill proteome signatures of four ecotypes identified by DIA
- •HSP47 and extracellular matrix proteins highly elevated in warm-adapted sticklebacks
- •Inflammasome and proteolytic proteins highly elevated in freshwater sticklebacks
4.
《Molecular & cellular proteomics : MCP》2018,17(12):2324-2334
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- •C9, GSN, PON1, and PON3 validated as serum biomarker candidates of EAC.
- •Multimarker panel with AUROC of 0.93 to aid current endoscopy surveillance of BE.
- •Induction of tissue C9 in BE, dysplastic BE and EAC.
- •Alteration of complement pathway glycoproteins during BE-EAC pathogenesis.
5.
《Molecular & cellular proteomics : MCP》2019,18(12):2516-2523
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- •Open source software for comprehensive HDX-MS data analysis.
- •Automatic back-exchange correction options.
- •Rigorous statistical analysis of the significance of uptake differences.
- •High quality visualization tools.
6.
《Molecular & cellular proteomics : MCP》2019,18(5):936-953
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- •In-depth proteome profiling of primary human myeloma cells
- •Characteristics of myeloma cells are related to hypoxic bone marrow conditions
- •Myeloma cells show specific immune evasion strategies
- •Metabolic adaptations involve tumor and stroma cells
7.
《Molecular & cellular proteomics : MCP》2019,18(11):2285-2297
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- •BioID with Golgi fractions identified C10orf76 as proximal to GBF1.
- •Tagged C10orf76 overlaps with Golgi markers.
- •C10orf76 binds GBF1 and exchanges rapidly between free and bound forms.
- •C10orf76 is essential for maintenance of the Golgi and for secretion.
8.
《Molecular & cellular proteomics : MCP》2019,18(2):200-215
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- •A global lysine succinylome was investigated in A. hydrophila.
- •The lysine succinylation modifications play crucial role on various metabolic pathways.
- •Reversible succinylation on Lys23 and Lys30 regulates the activity of S-ribosylhomocysteine lyase LuxS.
- •Lysine succinylation modifications of LuxS affect quorum sensing and metabolism.
9.
《Molecular & cellular proteomics : MCP》2019,18(2):391-405
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- •PTMiner software for intelligent post-processing of open-search results.
- •Unrestrictive modification site localization based on a Bayesian model.
- •Extended transfer FDR estimation for accurate grouped FDR estimation.
- •Comprehensive PTM characterization in a draft map of human proteome.
10.
《Molecular & cellular proteomics : MCP》2019,18(2):294-307
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- •We studied mid-pregnancy alcohol exposure and baboon fetal cerebral artery.
- •238 proteins differed between control and alcohol-exposed fetuses near-term.
- •Proteins of metabolic pathways represented one of the major targets of alcohol.
- •Alcohol effect on the development of fetal brain vessels is persistent.
11.
《Molecular & cellular proteomics : MCP》2019,18(2):320-337
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- •Hsp70 homologs differ in their oligomeric properties in the presence of ATP.
- •Human inducible Hsp70 forms ATP-dependent anti-parallel dimers with high propensity.
- •Dimerization of ATP-bound Hsp70 is required for effective Hsp70-Hsp40 interaction.
- •ATP-dependent interaction with Tomm34 TPR cochaperone disrupts Hsp70 dimer.
12.
《Molecular & cellular proteomics : MCP》2018,17(11):2284-2296
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- •Pre-formed and offset gradients for high throughput, robustness and peptide re-focusing.
- •Minimal cross-contamination by disposable trap columns and partial elution.
- •Single shot DIA measurements achieve >5000 proteins in 21 min.
13.
《Molecular & cellular proteomics : MCP》2019,18(5):865-875
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- •Microvesicle proteomics of 187 utero-tubal lavage samples for early diagnosis of HGOC.
- •Machine learning-based classification of a 9-protein signature with high predictive power.
- •Signature has 70‥ sensitivity and 76.2‥ specificity, predicting stage I lesions.
14.
《Molecular & cellular proteomics : MCP》2019,18(2):216-230
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- •Mice lacking Wip1 display spermatogenesis defects at the late-stage germ cell types.
- •Proteome and phosphoproteome profiling reveals impaired dynamics of testis junction.
- •Elevated levels of cytokines may lead to abnormal BTB structure and spermatogenesis.
15.
《Molecular & cellular proteomics : MCP》2019,18(6):1123-1137
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- •Changes to the proteome of skin fibroblasts subjected to reductive stress have been quantitated.
- •Only a small set of proteins is selectively diminished upon exposure to reductants.
- •Collagens (COL1A2 and COL6A2) emerge as sentinels of reductive stress.
- •Reductive stress triggers receptor-independent Akt phosphorylation at Ser473.
16.
《Molecular & cellular proteomics : MCP》2018,17(12):2518-2533
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- •Chromobodies are stabilized by antigen binding in live cells.
- •Monitoring changes of endogenous protein levels in living cells with chromobodies.
- •Broadly applicable system to generate turnover-accelerated chromobodies.
- •Quantification of time- and dose-dependent compound effects.
17.
《Molecular & cellular proteomics : MCP》2018,17(12):2496-2507
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- •Quantitative (phospho)proteome analysis of antibiotic treatment in E. coli.
- •Largest bacterial phosphorylation catalogue.
- •Specific phosphorylation motifs changes during resistance development.
- •Phosphorylation mediated signaling could be a potential target for drug design.
18.
《Molecular & cellular proteomics : MCP》2019,18(12):2348-2358
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- •Glycosylation is not currently considered in flu vaccine design.
- •Glycosylation influences on immunodominance are not well understood.
- •Identification of site-specific glycosylation using mass spectrometry has matured.
- •New methods are needed to quantify site-specific glycosylation for vaccine design.
19.
《Molecular & cellular proteomics : MCP》2019,18(5):982-994
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- •MaxQuant.Live controls Orbitrap mass analyzers in real-time.
- •Freely available apps enable advanced data acquisition strategies.
- •On-the-fly mass, retention time and intensity recalibration.
- •Global targeting unifies shotgun and targeted proteomics.
20.
《Molecular & cellular proteomics : MCP》2019,18(9):1705-1720
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- •Quantitative changes in global proteome and ubiquitinome in Huntington's disease.
- •Differential ubiquitination of wild-type and mutant Htt in mice brain.
- •Enriched pathways include vesicle transport and mRNA processing.
- •Correlation between protein and diGly site fold changes.