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1.
《Molecular & cellular proteomics : MCP》2019,18(5):936-953
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- •In-depth proteome profiling of primary human myeloma cells
- •Characteristics of myeloma cells are related to hypoxic bone marrow conditions
- •Myeloma cells show specific immune evasion strategies
- •Metabolic adaptations involve tumor and stroma cells
2.
《Molecular & cellular proteomics : MCP》2019,18(5):818-836
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- •Kallikrein-related peptidase 7 is over expressed in ovarian cancer.
- •Quantitative PROTOMAP and TAILS approaches identified putative substrates of KLK7.
- •Pro-MMP10 is activated by KLK7.
- •KLK7 cleaves thrombospondin 1 and IGFBP6 in vitro.
3.
《Molecular & cellular proteomics : MCP》2018,17(12):2518-2533
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- •Chromobodies are stabilized by antigen binding in live cells.
- •Monitoring changes of endogenous protein levels in living cells with chromobodies.
- •Broadly applicable system to generate turnover-accelerated chromobodies.
- •Quantification of time- and dose-dependent compound effects.
4.
《Molecular & cellular proteomics : MCP》2018,17(12):2496-2507
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- •Quantitative (phospho)proteome analysis of antibiotic treatment in E. coli.
- •Largest bacterial phosphorylation catalogue.
- •Specific phosphorylation motifs changes during resistance development.
- •Phosphorylation mediated signaling could be a potential target for drug design.
5.
《Molecular & cellular proteomics : MCP》2019,18(5):982-994
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- •MaxQuant.Live controls Orbitrap mass analyzers in real-time.
- •Freely available apps enable advanced data acquisition strategies.
- •On-the-fly mass, retention time and intensity recalibration.
- •Global targeting unifies shotgun and targeted proteomics.
6.
《Molecular & cellular proteomics : MCP》2019,18(2):231-244
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- •OMICS distinguish cancer cells from resistant or cancer stem cells.
- •Bactericidal antibiotics and mitochondria.
- •Linezolid and anticancer therapy.
7.
《Molecular & cellular proteomics : MCP》2019,18(3):477-489
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- •Developed a data processing pipeline to format phosphopeptide identifications.
- •Identified the preferred substrate motif for FLT3 and mutant kinases.
- •Designed and validated a panel of pan-FTL3 artificial substrates.
- •Monitored FLT3 and mutant kinase activity through FAStide phosphorylation.
8.
《Molecular & cellular proteomics : MCP》2019,18(11):2149-2164
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- •Enrichment of methyl peptides using two orthogonal techniques.
- •Knockdown of PRMT1 leads to substantial changes in protein arginine “methylome”.
- •Discrimination of ADMA and SDMA using characteristic neutral losses.
- •Identification of PRMT1 targets and substrate scavenged by other PRMTs in the absence of PRMT1 activity.
9.
《Molecular & cellular proteomics : MCP》2019,18(12):2516-2523
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- •Open source software for comprehensive HDX-MS data analysis.
- •Automatic back-exchange correction options.
- •Rigorous statistical analysis of the significance of uptake differences.
- •High quality visualization tools.
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11.
《Molecular & cellular proteomics : MCP》2019,18(6):1110-1122
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- •Comprehensive analysis of inter-individual variation of normal urinary proteome.
- •Significant gender differences were observed.
- •Proteins increased in female urine are enriched in immunological pathways.
- •Estimated reference intervals of proteins as the baseline for biomarker discovery.
12.
《Molecular & cellular proteomics : MCP》2019,18(1):127-150
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- •Quantitative proteomes of the 2016 WHO Neisseria gonorrhoeae reference strains.
- •Novel gonorrhea vaccine candidates and potential global proteomic AMR markers.
- •First large-scale proteomic profiling of gonorrhea vaccine candidates and AMR.
- •A reference proteomics databank for gonococcal vaccine and AMR research endeavors.
13.
《Molecular & cellular proteomics : MCP》2019,18(7):1345-1362
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- •Plant mitoribosomes contain several pentatricopeptide repeat proteins.
- •The small mitoribosomal subunit is of an exceptionally large size.
- •Protein units not directly related to translation may be attached to plant mitoribosomes to confer additional functions to these molecular machines.
14.
《Molecular & cellular proteomics : MCP》2019,18(3):490-503
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- •MHC-II-bound peptide repertoires from DO-sufficient and DO-deficient cells.
- •Fewer unique peptides and core epitopes were presented in the absence of DO.
- •Immunopeptidome differences appeared to result from reduced DM editing.
- •DO-dependent self-epitopes elicited CD4 T cell responses in mice.
15.
《Molecular & cellular proteomics : MCP》2019,18(7):1396-1409
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- •A panel of HEK293 isogenic cell lines with knockout of GALNT genes.
- •Identification of nonredundant O-glycosylation sites regulated by specific GalNAc-T isoforms.
- •GalNAc-T7 and T10 contribute to follow-up activity in regions of high density O-glycosylation.
- •GalNAc-T11 specifically controls O-glycosylation of specific linker regions in the low-density lipoprotein receptor related proteins.
16.
《Molecular & cellular proteomics : MCP》2019,18(6):1171-1182
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- •First report on the quantitative proteomic profiling of Drosophila lymph glands.
- •Comparative proteomic analysis under conditions of perturbed blood cell homeostasis.
- •Resource for identifying new regulators of insect and vertebrate hematopoiesis.
17.
《Molecular & cellular proteomics : MCP》2019,18(4):669-685
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- •quantitative phosphoproteome analysis of TDM-activated macrophages.
- •distinct Mincle-dependent and independent phosphorylation and gene regulations.
- •Mincle-dependent activation of PI3K/AKT signaling by TDM.
- •Mincle-independent macrophage response is linked to cell cycle regulation.
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19.
《Molecular & cellular proteomics : MCP》2018,17(12):2309-2323
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- •First global study on metabolic regulation of Nt-acetylation.
- •Yeast cells maintain global Nt-acetylation levels during prolonged starvation.
- •Nt-acetylation can in some cases be either up- or downregulated by starvation.
- •Naa10/NatA affects the steady-state protein levels of Rsa3 and Rpl7a.
20.
《Molecular & cellular proteomics : MCP》2019,18(5):892-908
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- •Interplay of epithelial cells and internalized S. aureus was dissected over 96 h.
- •Surviving host cells contain nonreplicating bacteria that persists in the cytoplasm.
- •Competition over resources triggers temporal metabolic changes.
- •Metabolic adaptation of host and bacteria determines the outcome of infection.