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1.
The 20th IUPAB Congress took place online, together with the annual meetings of the Brazilian Biophysical Society and the Brazilian Society for Biochemistry and Molecular Biology, from the 4th to the 8th of October, 2021. The ten keynote lectures, 24 symposia, two poster sessions, and a series of technical seminars covered the full diversity of current biophysical research and its interfaces with other fields. The event had over 1000 attendees, with an excellent gender balance. Although the Americas dominated, there were also significant numbers of participants from Europe, Asia, and Africa.The International Union of Pure and Applied Biophysics (IUPAB) came into existence in Stockholm in 1961 and has been a member of the International Science Council since 1966 (Solomon 1968). Its overall objectives aim to foster international collaboration in all aspects of biophysics and related areas and to catalyze the advancement of basic biophysical research as well as its many applications. Although IUPAB is active on many fronts, undeniably one of its showcase events is the IUPAB Congress, traditionally organized every three years in different locations worldwide. In 2021, the event was organized and run from Brazil, albeit for the very first time in a virtual format due to travel restrictions imposed by the COVID-19 pandemic. On this occasion, the Congress was organized in conjunction with the annual meetings of both the Brazilian Biophysical Society (SBBf, in its 45th edition) and the Brazilian Society for Biochemistry and Molecular Biology (SBBq, in its 50th edition). Even with the united forces of these well-established local societies, it turned out to be a bumpy ride to bring the event to fruition.Plans for the 20th Congress began in 2016, almost immediately after the decision to hold the event in Brazil, a cause championed by the then-president of the Brazilian Biophysical Society, Marcelo Morales. The original plans had the meeting to be held in the Cidade Maravilhosa (The Wonderful City) of Rio de Janeiro in October 2020. However, it soon became apparent that the political and economic difficulties that the State of Rio was facing at the time meant that it would be wise to search for an alternative venue. The previous experience of SBBq in organizing similar events in the city of Foz do Iguaçu, on the borders with Argentina and Paraguay, made this an obvious choice. Furthermore, the natural attraction of the spectacular Iguaçu waterfalls seemed to be an ideal compensation for Sugar Loaf Mountain, Copacabana beach, and the statue of Christ the Redeemer on Corcovado Mountain.Then came the pandemic. By mid-2020, it had become apparent that there were too many unknowns to make it possible to proceed with an in-person event in October of that year. It was decided to postpone the congress to 2021 but with a firm belief that things would be “back to normal.” Sweet delusion! As 2020 turned into 2021 and the severity and longevity of the pandemic became clearer and clearer (not to mention the abysmal performance of the Brazilian government in failing to rise to the challenge), the inevitable decision was taken to transform the event into an “on-line” congress. This was a first for both the local organizers and the IUPAB.The move to an online format immediately had an impact on the organization of the Young Scientist Program. This was initially envisaged to be a combination of formal and informal activities aimed at uniting about 40 early carrier scientists and post-docs for a couple of days prior to the main event in a stimulating atmosphere conducive to networking. Skillfully conceived, organized, and executed by Eneida de Paula (Campinas) and Eduardo Reis (São Paulo), this too had to be adapted to a “virtual reality.” The successful solution turned out to be a series of fortnightly thematic webinars, including a talk from a recognized authority in the field followed by three or four short presentations from the participants themselves (Table ). The standard was extremely high and the YSP ended up being a highly effective warm-up to the congress itself. Furthermore, there was excellent geographical diversity among the participants with Europe, Africa, Asia, the Middle East, and both North and South America represented. Table 1Young Scientist Webinar Program Date | General subject area | Invited speaker |
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19th May | Biomimetic Structures and Systems/Multiscale Biophysics of Membranes | Manuel Prieto, Portugal | 26th May | Cell Biophysics and Phase Transition | Clifford Brangwynne, USA | 9th June | Plant biotechnology/Biofuels/Bioenergy | Igor Polikarpov, Brazil | 23rd June | Applications in Biomedical and Materials Science | – | 7th July | Mechanisms of Membrane Protein | Natalie Strynadka, Canada | 21st July | Membrane Permeation: Channels and Transporters | Eduardo Perozo, USA | 4th August | Bioenergetics and Metabolism | Alicia Kowaltowski, Brazil | 18th August | Protein Structure to Function/Structural Biology | Wah Chiu, USA | 1st September | Computational Biophysics and Biochemistry | Ingemar André, Sweden | 15th September | Drug Discovery and Delivery | Fabio Sonvico, Italy | Open in a separate windowThe main event attracted over 1000 participants, with an excellent gender balance. Although the Americas dominated, there were also significant numbers of participants from Europe, Asia, and Africa (Fig. ). Table gives an excellent idea of the diverse subject matter covered during the 5 days of the congress itself. As to be expected, the way in which biophysics naturally interfaces with biochemistry, molecular biology, cell biology, chemistry (including medicinal chemistry), physics, engineering, etc. was more than apparent. Nevertheless, several themes appeared to be particularly recurrent throughout the event. Notwithstanding the plethora of other topics, several main threads permeated the proceedings, and these included (1) lipids, membranes, their assembly, and dynamics; (2) bioimaging at all levels; (3) drug targets and drug development/delivery; and (4) molecular recognition including membrane/protein interactions. This special issue aims to cover the main topics of the event as comprehensively as possible in similar vein to previous efforts (Hall and dos Remedios, 2017). In over 50 articles, including reviews, commentaries, letters, and editorials, we aim to convey the full flavor of the congress. It is hoped that this will serve simultaneously as both a useful source of reference and a historical record. The short, focused review articles are all up-to-date and expected to be of particular value to a broad readership. We hope that you enjoy them as much as we have and find them to be instructive and beneficial. Open in a separate windowParticipants by continent Table 2Symposia organized during the 20th IUPAB Congress Title | Chair |
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Drug design and delivery | Joke Bouwstra (Leiden, Netherlands) | Protein Structure, Dynamics and Function | Richard Garratt (São Carlos, Brazil) | Biological Photosensors and their Applications in Optogenetics | Silvia Braslavsky (MPI, Germany) | Macromolecular Machines and Switching Devices | Alejandro Buschiazzo (Montevideo, Uruguay) | RSC–Chemical Biology | Randall Peterson (Utah, USA) | Young Talent in Life Sciences (Cytiva Award) | Juliana Fietto (Viçosa, Brazil) | Deforming Membranes | Patricia Bassereau (Curie Institute, France) | Systems Biology and Biomarkers for Human Disorders | Peter Nilson (KTH, Stockholm, Sweden) | PABMB Symposium: Metabolism and Bioenergetics | Alicia Kowaltowski (São Paulo, Brazil) | Biophotonics | Georg Wondrak/Martha Ribeiro (Arizona, USA/São Paulo, Brazil) | Microbiomes: human and environmental | Leda Vieira (Belo Horizonte, Brazil) | Molecular and Cell Imaging | Paulo Bisch (Rio de Janeiro, Brazil) | Ionic Channels and Membrane Transporters | John Baenziger (Chicago, USA) | Biomolecular Association and Dynamics | Paul Whitford (Boston, USA) | Gender in Science | Cristina Nonato/David Crossman (Ribeirão Preto, Brazil/Aukland, New Zealand) | Protein Folding, Misfolding and Unfolding | Vladimir Uversky (Tampa, USA) | EBSA Symposium on Translational Biophysics | Anthony Watts/Jesús Pérez-Gil (Oxford, UK/Madrid, Spain) | Autophagy: Mechanisms and Applications | Marcelo Mori (Campinas, Brazil) | Membrane Simulation | Mikko Karttunen (Ontario, Canada) | Systems Biologics: at the interface… | Stephen Michnick (Montreal, Canada) | IUBMB Symposium: Science Education | Manuel João Costa (U. Minho, Portugal) | Scissioning Membranes | Rumiana Dimova (Potsdam, Germany) | Redox Biology | Rafael Radi (Montevideo, Uruguay) | Biophysics of the Immune System | Jean-Marie Ruysschaert (Brussels, Belgium) | Open in a separate windowAll of the Keynote lectures (Table ) were very well attended. The Nobel laureate Richard Henderson set the ball rolling with a beautifully clear historical overview of how cryo-EM got to be where it is now and what we might expect for the near future. Tony Watts (the new president-elect of IUPAB) closed the event with the Avanti/IUPAB award lecture and a clear message that biophysics is not all about proteins—lipids are important (also)! Midweek, a second Nobel prize winner, Michael Levitt, gave his take on the COVID-19 pandemic by applying his talent for mathematical modeling in much the same way as he so successfully applied it to macromolecular systems in the past. At the very least, his talk gave plenty of food for thought to those who were present. Table 3Keynote speakers Speaker | Title |
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Richard Henderson (LMB, Cambridge) | Impact of Single Particle Cryo-electron Microscopy on Structural Biology | Carlos Bustamante (University of California, Berkeley) | Co-temporal Force and Fluorescence Measurements Reveal a Ribosomal Gear-shift Mechanism of Translation Regulation by mRNA Secondary Structures | Giorgio Trinchieri (Center for Cancer Research, NIH, Maryland) | Targeting the microbiome in cancer immunotherapy | Tao Xu (Chinese Academy of Sciences) | The Bei Shizhang Lecture: Cryogenic superresolution correlative light and electron microscopy on the frontier od subcellular imaging | Michael Levitt (Stanford) | Lessons from 620 days Studying COVID-19 | Ohara Augusto (São Paulo) | Carbon Dioxide Redox Metabolites in Eustress and Oxidative Distress | Ramon Latorre (Valparaíso) | Calcium-driven Voltage Sensingand the role of Charged Residues in the voltage sensor domain of BK | Angela Gronenborn (Pittsburgh) | The Awesome Power of Fluorine NMR | Yoav Shechtman (Haifa) | IUPAB Young Investigator Lecture: Next Generation Localization Microscopy—or How and Why to Ruin and Perfectly Good Microscope | Anthony Watts (Oxford) | Avanti/IUPAB Award Lecture: Lipids are important | Open in a separate windowOverall, the sessions were very well attended with typically over 200 participants. The ease of moving from one session to another under the virtual format proved to be a notable advantage. Furthermore, since many of the talks were pre-recorded, most of the sessions kept to time rather better than is often the case at traditional events. The two poster sessions were also very well frequented, and the pre-recorded videos were generally of high quality. Approximately 10% of all poster presenters were awarded prizes during the closing ceremony, and six special prizes were generously provided by the Royal Society of Chemistry.Several special activities were held throughout the week. These included technical seminars by some of the sponsors, including Cytiva, Thermo-Fisher, and Sartorius as well as sessions devoted to Brazil-German exchange programs and one on “Gender in Science.” The latter was particularly motivational for the congress participants, whose demographic was heavily biased towards early-career scientists, post-docs, and students (Fig. ). Biophysical Reviews organized two early-morning sessions, one of which was an editorial board meeting whilst the other was open to all interested parties and represented an opportunity to promote the journal within the community. The IUPAB held its general assembly on the 6th of October. Manuel Prieto formally took over as President with Marcelo Morales stepping down but continuing as a council member in the role of immediate Past President. Tony Watts becomes the new President Elect. Open in a separate windowThe distribution of participants according to their stage in the careerDespite the challenges of organizing a widely diverse international event online, we came away with the feeling of a mission accomplished and the hope that we will be able to meet up in person in the very near future. From the extremely high standard of the presentations and the overall satisfaction of the participants, we think it can be considered to have been a success. See you all in Kyoto! 相似文献
3.
Introduction: The authors initiated the use of Liqui‐PREP? (LGM International Inc., Fort Lauderdale, FL, USA) in August, 2005. Cytotechnologists received extensive (one month) training by cytopathologists experienced in Liquid‐based cytology. The Liqui‐PREP? direct‐to‐vial procedure (LP) was compared to the conventional Pap smears in a routine screening population. Methods: Data derived from 26 178 LP cervical‐vaginal (CV) specimens were compared to data derived from 218 548 conventional Pap smears (CS). Both data sets reflect patient samples collected concurrently (August–December, 2005) by 117 participating outpatient medical practices from a well‐defined geographic area. There were no significant personnel changes during the study period. The diagnostic results, classified according to Bethesda criteria were calculated. Results: | % ASC‐US | % ASC‐H | % LSIL | % HSIL+ | ASCUS/ LSIL+ | % Unsat. | Liqui‐PREP? | 6.5 | 0.24 | 1.55 | 0.39 | 3.8 | 0.02 | Conv. Smear | 2.8 | 0.09 | 0.50 | 0.25 | 4.0 | 0.05 | Discussion: Liqui‐PREP? direct‐to‐vial method for CV specimens identified 210% more LSIL and 56% more HSIL+ lesions compared to the conventional smears. The ASCUS rate was increased (perhaps due to the conservative nature of our staff and their cautious interpretation of a new preparation). The ratio of ASCUS to LSIL+ was reduced by 5% for Liqui‐Prep?. Available biopsy data showed high correlation between both LP and CS abnormal cytology diagnoses (94.1% and 89.9% respectively). These findings suggest that the Liqui‐PREP? cytology preparation procedure identifies more pre‐malignant lesions than the conventional smear. 相似文献
4.
Recent studies suggest that seaweed extracts are a significant source of bioactive compounds comparable to the dietary phytochemicals such as onion and tea extracts. The exploration of natural antioxidants that attenuate oxidative damage is important for developing strategies to treat obesity‐related pathologies. The objective of this study was to screen the effects of seaweed extracts of 49 species on adipocyte differentiation and reactive oxygen species (ROS) production during the adipogenesis in 3T3‐L1 adipocytes, and to investigate their total phenol contents and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging activities. Our results show that high total phenol contents were observed in the extracts of Ecklonia cava (see Table 1 for taxonomic authors) (681.1 ± 16.0 μg gallic acid equivalents [GAE] · g ?1), Dictyopteris undulata (641.3 ± 70.7 μg GAE · g ?1), and Laurencia intermedia (560.9 ± 48.1 μg GAE · g ?1). In addition, DPPH radical scavenging activities were markedly higher in Sargassum macrocarpum (60.2%), Polysiphonia morrowii (55.0%), and Ishige okamurae (52.9%) than those of other seaweed extracts ( P < 0.05). Moreover, treatment with several seaweed extracts including D. undulata, Sargassum micracanthum, Chondrus ocellatus, Gelidium amansii, Gracilaria verrucosa, and Grateloupia lanceolata significantly inhibited adipocyte differentiation and ROS production during differentiation of 3T3‐L1 preadipocytes. Furthermore, the production of ROS was positively correlated with lipid accumulation ( R2 = 0.8149). According to these preliminary results, some of the seaweed extracts can inhibit ROS generation, which may protect against oxidative stress that is linked to obesity. Further studies are required to determine the molecular mechanism between the verified seaweeds and ROS, and the resulting effects on obesity. Table 1. List of Korean seaweed extracts of 49 species evaluated in this experiment. Type | No. | Scientific name | Collection time | TP1 (μg GAE · g?1) | Brown macroalgae | SE‐1 | Chondracanthus tenellus (Harv.) Hommers. | April 27, 2006 | 112.8 ± 15.1lm | SE‐2 | Colpomenia sinusa (F. C. Mertens ex Roth) Derbes et Solier in Castagne | May 11, 2006 | 44.0 ± 4.1opqrs | SE‐3 | Dictyopteris divaricata (Okamura) Okamura | April 6, 2006 | 41.5 ± 5.6pqrs | SE‐4 | Dictyopteris pacifica (Yendo) I. K. Hwang, H.‐S. Kim et W. J. Lee | April 27, 2006 | 80.9 ± 8.3mno | SE‐5 | Dictyopteris prolifera (Okamura) Okamura | November 26, 2007 | 48.4 ± 3.0nopqrs | SE‐6 | Dictyopteris undulata Holmes | July 28, 2007 | 641.3 ± 70.7b | SE‐7 | Dictyota asiatica I. K. Hwang | April 6, 2006 | 52.9 ± 7.6nonopqr | SE‐8 | Ecklonia cava Kjellm. | October 22, 2006 | 681.1 ± 16.0a | SE‐9 | Ecklonia stolonifera Okamura | November 26, 2007 | 36.5 ± 3.4pqrs | SE‐10 | Endarachne binghamiae J. Agardh | March 10, 2006 | 50.4 ± 2.6nopqrs | SE‐11 | Hizikia fusiformis (Harv.) Okamura | July 23, 2006 | 16.4 ± 1.2rs | SE‐12 | Hydroclathrus clathratus (C. Agardh) M. Howe | May 11, 2006 | 18.1 ± 0.9rs | SE‐13 | Ishige okamurae Yendo | May 26, 2006 | 237.4 ± 1.6h | SE‐14 | Lethesia difformis (L.) Aresch. | May 11, 2006 | 11.2 ± 1.9s | SE‐15 | Myelophycus simplex (Harv.) Papenf. | April 27, 2006 | 39.5 ± 3.2pqrs | SE‐16 | Padina arborescens Holmes | July 29, 2007 | 172.9 ± 23.1ij | SE‐17 | Sargassum fulvellum (Turner) C. Agardh | April 27, 2006 | 119.1 ± 5.6kl | SE‐18 | Sargassum micracanthum (Kütz.) Endl. | December 21, 2006 | 468.0 ± 22.7e | SE‐19 | Sargassum patens C. Agardh | January 21, 2007 | 41.5 ± 5.7pqrs | SE‐20 | Sargassum confusum C. Agardh f. validum Yendo | March 8, 2008 | 110.9 ± 3.5lm | SE‐21 | Sargassum horneri (Turner) C. Agardh | March 1, 2006 | 84.8 ± 9.4lmn | SE‐22 | Sargassum macrocarpum C. Agardh | January 21, 2007 | 353.9 ± 59.1g | SE‐23 | Sargassum muticum (Yendo) Fensolt | January 21, 2007 | 72.1 ± 14.9nop | SE‐24 | Sargassum nipponium Yendo | April 6, 2006 | 54.0 ± 3.5nopqr | SE‐25 | Sargassum sagamianum Yendo | March 8, 2008 | 41.0 ± 6.7pqrs | SE‐26 | Sargassum thunbergii (Mertens ex Roth) Kuntze | July 23, 2006 | 27.7 ± 0.8qrs | SE‐27 | Scytosiphon gracilis Kogame | May 26, 2006 | 30.2 ± 5.6qrs | SE‐28 | Scytosiphon lomentaria (Lyngb.) Link | May 11, 2006 | 66.5 ± 8.9nopq | Red macroalgae | SE‐29 | Bonnemaisonia hamifera Har. | April 27, 2006 | 44.1 ± 2.3opqrs | SE‐30 | Callophyllis crispata Okamura | May 11, 2006 | 37.6 ± 12.6pqrs | SE‐31 | Chondria crassicaulis Harv. | May 11, 2006 | 45.4 ± 4.4opqrs | SE‐32 | Chondrus crispus Stackh. | May 26, 2006 | 40.7 ± 8.0pqrs | SE‐33 | Chondrus ocellatus Holmes | May 11, 2006 | 47.2 ± 1.7nopqrs | SE‐34 | Gelidium amansii (J. V. Lamour.) J. V. Lamour. | April 27, 2006 | 525.3 ± 35.9d | SE‐35 | Gloioperltis furcata (Postels et Rupr.) J. Agardh | May 26, 2006 | 147.7 ± 6.4jk | SE‐36 | Gloioperltis complanta (Harv.) Yamada | May 26, 2006 | 58.2 ± 6.4nopq | SE‐37 | Gracilaria verrucosa (Hudson) Papenf. | March 6, 2008 | 55.1 ± 7.5nopqr | SE‐38 | Grateloupia elliptica Holmes | May 26, 2006 | 154.4 ± 12.9j | SE‐39 | Grateloupia filicina (J. V. Lamour.) C. Agardh | May 11, 2006 | 38.2 ± 2.2pqrs | SE‐40 | Grateloupia lanceolata (Okamura) Kawag. | July 23, 2006 | 32.7 ± 3.0pqrs | SE‐41 | Laurencia intermedia J. V. Lamour. | May 11, 2006 | 560.9 ± 48.1c | SE‐42 | Laurencia intricata J. V. Lamour. | April 27, 2006 | 35.4 ± 4.0pqrs | SE‐43 | Laurencia okamurae Yamada | May 11, 2006 | 193.2 ± 41.9i | SE‐44 | Lomentaria hakodatensis Yendo | April 27, 2006 | 165.2 ± 15.1ij | SE‐45 | Polyopes affinis (Harv.) Kawag. et H.‐W. Wang | May 26, 2006 | 42.9 ± 2.3opqrs | SE‐46 | Polysiphonia morrowii Harv. | May 11, 2006 | 392.4 ± 40.3f | SE‐47 | Prionitis cornea (Okamura) E. Y. Dawson | October 22, 2006 | 47.9 ± 3.6nopqrs | Green macroalgae | SE‐48 | Enteromorpha prolifera (O. F. Müll.) J. Agardh | March 26, 2006 | 42.0 ± 5.3pqrs | SE‐49 | Ulva pertusa Kjellm. | April 27, 2006 | 48.3 ± 3.8nopqrs | - GAE, gallic acid equivalents; SE, seaweed extracts.
- 1TP, total phenol content is micrograms of total phenol contents per gram of seaweed extract based on gallic acid as standard. The values are means ± SD from three replications.
- a–sMeans in the same column not sharing a common letter are significantly different (P < 0.05) by Duncan’s multiple test.
Citing Literature Number of times cited according to CrossRef: 21 - Kas?m Cemal Güven, Burak Coban, Osman Özdemir, Pharmacology of Marine Macroalgae, Encyclopedia of Marine Biotechnology, 10.1002/9781119143802, (585-615), (2020). Wiley Online Library
- Giovanna Bermano, Teodora Stoyanova, Franck Hennequart, Cherry L. Wainwright, Seaweed-derived bioactives as potential energy regulators in obesity and type 2 diabetes, , 10.1016/bs.apha.2019.10.002, (2019). Crossref
- Ana Rocío Múzquiz de la Garza, Mireya Tapia-Salazar, Maribel Maldonado-Muñiz, Julián de la Rosa-Millán, Janet Alejandra Gutiérrez-Uribe, Liliana Santos-Zea, Bertha Alicia Barba-Dávila, Denis Ricque-Marie, Lucía Elizabeth Cruz-Suárez, Nutraceutical Potential of Five Mexican Brown Seaweeds, BioMed Research International, 10.1155/2019/3795160, 2019 , (1-15), (2019). Crossref
- M. Lynn Cornish, Alan T. Critchley, Ole G. Mouritsen, A role for dietary macroalgae in the amelioration of certain risk factors associated with cardiovascular disease, Phycologia, 10.2216/15-77.1, 54 , 6, (649-666), (2019). Crossref
- Carolina Gonçalves-Fernández, Jorge Sineiro, Ramón Moreira, Oreste Gualillo, Extraction and characterization of phlorotannin-enriched fractions from the Atlantic seaweed Bifurcaria bifurcata and evaluation of their cytotoxic activity in murine cell line, Journal of Applied Phycology, 10.1007/s10811-018-1729-2, (2019). Crossref
- Noelia Flórez‐Fernández, María P Casas, María Jesús González‐Muñoz, Herminia Domínguez, Microwave hydrogravity pretreatment of Sargassum muticum before solvent extraction of antioxidant and antiobesity compounds, Journal of Chemical Technology & Biotechnology, 10.1002/jctb.5771, 94 , 1, (256-264), (2018). Wiley Online Library
- Yannick Lerat, M. L. Cornish, Alan T. Critchley, Stéphane La Barre, Stephen S. Bates, Applications of Algal Biomass in Global Food and Feed Markets: From Traditional Usage to the Potential for Functional Products, Blue Biotechnology, 10.1002/9783527801718, (143-189), (2018). Wiley Online Library
- Gabriele Andressa Zatelli, Ana Cláudia Philippus, Miriam Falkenberg, An overview of odoriferous marine seaweeds of the Dictyopteris genus: insights into their chemical diversity, biological potential and ecological roles, Revista Brasileira de Farmacognosia, 10.1016/j.bjp.2018.01.005, 28 , 2, (243-260), (2018). Crossref
- Cyr Abel Maranguy Ogandaga, Yeon Ju Na, Sang-Rae Lee, Young Sik Kim, Han Gil Choi, Ki Wan Nam, Wart-like spot formation on the fronds of Chondrus ocellatus (Gigartinales) by a brown alga, Mikrosyphar zosterae (Ectocarpales) in Korea, Journal of Applied Phycology, 10.1007/s10811-016-1028-8, 29 , 5, (2539-2546), (2017). Crossref
- Fook Yee Chye, Birdie Scott Padam, Seah Young Ng, Innovation and Sustainable Utilization of Seaweeds as Health Foods, Sustainability Challenges in the Agrofood Sector, 10.1002/9781119072737, (390-434), (2017). Wiley Online Library
- Gaurav Rajauria, Lynn Cornish, Francesco Ometto, Flower E. Msuya, Raffaella Villa, Identification and selection of algae for food, feed, and fuel applications, Seaweed Sustainability, 10.1016/B978-0-12-418697-2.00012-X, (315-345), (2015). Crossref
- Jatinder Sangha, Owen Wally, Arjun Banskota, Roumiana Stefanova, Jeff Hafting, Alan Critchley, Balakrishnan Prithiviraj, A Cultivated Form of a Red Seaweed (Chondrus crispus), Suppresses β-Amyloid-Induced Paralysis in Caenorhabditis elegans, Marine Drugs, 10.3390/md13106407, 13 , 10, (6407-6424), (2015). Crossref
- Jung-Ae Kim, Fatih Karadeniz, Byul-Nim Ahn, Myeong Sook Kwon, Ok-Ju Mun, Mihyang Kim, Sang-Hyeon Lee, Ki Hwan Yu, Yuck Yong Kim, Chang-Suk Kong, Sargassum sp. Attenuates Oxidative Stress and Suppresses Lipid Accumulation in vitro, Journal of Life Science, 10.5352/JLS.2014.24.3.274, 24 , 3, (274-283), (2014). Crossref
- Georgia M. Hart, Tamara Ticktin, Dovi Kelman, Anthony D. Wright, Nicole Tabandera, Contemporary Gathering Practice and Antioxidant Benefit of Wild Seaweeds in Hawai’i, Economic Botany, 10.1007/s12231-014-9258-7, 68 , 1, (30-43), (2014). Crossref
- Zahid Manzoor, Vivek Bhakta Mathema, Doobyeong Chae, Eun-Sook Yoo, Hee-Kyoung Kang, Jin-Won Hyun, Nam Ho Lee, Mi-Hee Ko, Young-Sang Koh, Extracts of the seaweed Sargassum macrocarpum inhibit the CpG-induced inflammatory response by attenuating the NF-κB pathway, Food Science and Biotechnology, 10.1007/s10068-014-0041-4, 23 , 1, (293-297), (2013). Crossref
- Jatinder Singh Sangha, Di Fan, Arjun H. Banskota, Roumiana Stefanova, Wajahatullah Khan, Jeff Hafting, James Craigie, Alan T. Critchley, Balakrishnan Prithiviraj, Bioactive components of the edible strain of red alga, Chondrus crispus, enhance oxidative stress tolerance in Caenorhabditis elegans, Journal of Functional Foods, 10.1016/j.jff.2013.04.001, 5 , 3, (1180-1190), (2013). Crossref
- Areum Daseul Kim, Mei Jing Piao, Yu Jae Hyun, Hee Kyoung Kang, In Soo Suh, Nam Ho Lee, Jin Won Hyun, Photo-protective properties of Lomentaria hakodatensis yendo against ultraviolet B radiation-induced keratinocyte damage, Biotechnology and Bioprocess Engineering, 10.1007/s12257-012-0336-3, 17 , 6, (1223-1231), (2013). Crossref
- Min‐Jung Seo, Hyeon‐Son Choi, Ok‐Hwan Lee, Boo‐Yong Lee, Grateloupia lanceolata (Okamura) Kawaguchi, the Edible Red Seaweed, Inhibits Lipid Accumulation and Reactive Oxygen Species Production During Differentiation in 3T3‐L1 Cells, Phytotherapy Research, 10.1002/ptr.4765, 27 , 5, (655-663), (2012). Wiley Online Library
- Mi‐Seon Woo, Hyeon‐Son Choi, Ok‐Hwan Lee, Boo‐Yong Lee, The Edible red Alga, Gracilaria verrucosa, Inhibits Lipid Accumulation and ROS Production, but Improves Glucose Uptake in 3T3‐L1 Cells, Phytotherapy Research, 10.1002/ptr.4813, 27 , 7, (1102-1105), (2012). Wiley Online Library
- Young-Jun Lee, Bo-Ra Yoon, Hyeon-Son Choi, Boo-Yong Lee, Ok-Hwan Lee, Effect of Sargassum micracanthum extract on Lipid Accumulation and Reactive Oxygen Species (ROS) Production during Differentiation of 3T3-L1 Preadipocytes, Korean Journal of Food Preservation, 10.11002/kjfp.2012.19.3.455, 19 , 3, (455-461), (2012). Crossref
- Mei Piao, Yu Hyun, Suk Cho, Hee Kang, Eun Yoo, Young Koh, Nam Lee, Mi Ko, Jin Hyun, An Ethanol Extract Derived from Bonnemaisonia hamifera Scavenges Ultraviolet B (UVB) Radiation-Induced Reactive Oxygen Species and Attenuates UVB-Induced Cell Damage in Human Keratinocytes, Marine Drugs, 10.3390/md10122826, 10 , 12, (2826-2845), (2012). Crossref
Volume 47 , Issue 3 June 2011 Pages 548-556 相似文献
7.
Differential scanning calorimetry was used to directly determine the transition enthalpies accompanying the duplex-to-single-strand transition of poly[d(AT)], poly(dA)·poly(dT), poly[d(AC)]·poly[d(TG)], and d(GCGCGC). The calorimetric data allow us to define the following average base-stacking enthalpies: Interaction | ΔH (kcal/stack) | AC/TG, TG/AC | 5.6 | AT/TA, TA/AT | 7.1 | AA/TT | 8.6 | GC/CG, CG/GC | 11.9 | Comparison with published data on the corresponding RNA interactions reveals remarkably good agreement. By assuming transition enthalpies to result from the pairwise disruption of nearest-neighbor stacking interactions, we used the enthalpy data listed above to predict the transition enthalpies for three oligomeric DNA duplexes. Excellent agreement was found between the predicted and the calorimetrically determined values. 相似文献
10.
Aim: To compare the efficacy of 14‐day and 5‐day amoxicillin treatment on the eradication rate during tetracycline containing sequential H. pylori therapy, and also to compare the eradication rate of this regimen with those used in similar studies performed in Turkey. Method: This study included 112 patients infected with H. pylori that were randomized into 2 groups. In group A, patients (n = 56) received pantoprazole (40 mg BID) and amoxicillin (1 g BID) for 5 days, followed by pantoprazole (40 mg BID), tetracycline (500 mg QID), and metronidazole (500 mg TID) for the remaining 9 days. In group B, patients (n = 56) received pantoprazole (40 mg BID) and amoxicillin (1 g BID) for 5 days, followed by pantoprazole (40 mg BID), tetracycline (500 mg QID), metronidazole (500 mg TID), and amoxicillin (1 g BID) for the remaining 9 days. Eradication rates were calculated using both intention‐to‐treat (ITT) and per‐protocol (PP) analyses. Results: In all, 112 patients were subjected to ITT analysis and 109 patients completed the study. In group A, H. pylori eradication was achieved in 46 (82.1%) of the 56 patients included in the ITT analysis and in 46 (83.6%) of the 55 patients included in the PP analysis. In group B, H. pylori eradication was achieved in 44 (78.57%) of the 56 patients included in the ITT analysis and in 44 (81.48%) of the 54 patients included in the PP analysis ( Table 2 ). The eradication rates were not statistically significant between the 2 groups ( p > .005). Table 2. Eradication rates in the two study groups | Group A | Group B | p | n | ITT/PP | n | ITT/PP | Eradication | Female | 21 | 70%/72.4% | 34 | 79.06%/82.9% | NS | Male | 25 | 6.1%/96.1% | 10 | 76.9%/76.9% | NS | Total | 46 | 82.1%/83.6% | 44 | 78.57%/81.48% | NS | - NS, not significant; PP, per‐protocol; ITT, intention‐to‐treat.
Conclusion: Extended duration of amoxicillin treatment during the entire tetracycline containing sequential therapy period did not improve the H. pylori eradication rate. As a consequence, sequential therapy using 5‐day amoxicillin is an acceptable first‐line therapy option for the eradication of H. pylori in Turkey. 相似文献
11.
Introduction Direct endometrial sampling with cytology and or histology is used at our hospital as part of the investigation of abnormal uterine bleeding. It is used in cases where there is a low clinical suspicion of malignancy. The advantage of the technique is that it can be done as an outpatient procedure with minimal patient discomfort. Reports in the literature give mixed results. We present a 3‐year retrospective of our experience with follow‐up. Result | Cytology | Biopsy | Follow‐up histology | Inadequate | 9 | 9 | One ovarian adenocarcinoma | negative | 75 | 66 | One adenocarcinoma nine benign | Suspicious | 3 | One hyperplasia | One hyperplasia one polyp | Malignant | 1 | 1 | Adenocarcinoma | Total | 88 | 77 | 16 | Results Eighty‐eight cases were examined with an age range of 42–82. Review of the false negative case showed no malignant cells and is likely to represent a sampling problem. Conclusions - 1 The technique is useful in identifying low risk patients, only 16 of 88 had further histological investigation.
- 2 Increased experience and better recognition of the different cytological appearances should improve the diagnostic accuracy.
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13.
The basic idea of the source simulation technique is to replace the scatterer (or radiator by a system of simple sources located within the envelope of the original body. The extent to which the simulated field reproduces the original field depends on the degree of correspondence between the simulated and the given boundary conditions. Numerical simulations have shown that: (1) the shape of the auxiliary surface, (2) the number of sources, and (3) the way the sources are distributed are the most relevant parameters to ensure an accurate solution for the problem. In the case of the single-layer method, sources should not be positioned close to the center of the body, because the problem becomes ill-conditioned. The auxiliary surface and the scatterer should be as similar as possible in order to minimize the boundary error. With respect to the number of sources (N), there are two opposite effects: (1) if (N) is too small, the sound field is not reproduced accurately; (2) if (N) is too large, computing time increases and solution accuracy decreases. The method beaks down when excitation frequency coincides with the eigenfrequencies — a narrow range of frequencies — of the space formed by the auxiliary surface. As the auxiliary surface is frequently represented by simple surfaces (cylinder, sphere), one can easily calculate the eigenfrequencies and therefore avoid them. PDF (545 K)
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