共查询到20条相似文献,搜索用时 15 毫秒
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Toru Sengoku Masaaki Shiina Kae Suzuki Keisuke Hamada Ko Sato Akiko Uchiyama Shunsuke Kobayashi Asako Oguni Hayato Itaya Kota Kasahara Hirotomo Moriwaki Chiduru Watanabe Teruki Honma Chikako Okada Shiho Baba Tsutomu Ohta Hozumi Motohashi Masayuki Yamamoto Kazuhiro Ogata 《Nucleic acids research》2022,50(21):12543
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Signal transduction between a membrane-bound transporter, PtsG, and a soluble transcription factor, Mlc, of Escherichia coli 下载免费PDF全文
The global regulator Mlc controls several genes implicated in sugar utilization systems, notably the phosphotransferase system (PTS) genes, ptsG, manXYZ and ptsHI, as well as the malT activator. No specific low molecular weight inducer has been identified that can inactivate Mlc, but its activity appeared to be modulated by transport of glucose via Enzyme IICB(Glc) (PtsG). Here we demonstrate that inactivation of Mlc is achieved by sequestration of Mlc to membranes containing dephosphorylated Enzyme IICB(Glc). We show that Mlc binds specifically to membrane fractions which carry PtsG and that excess Mlc can inhibit Enzyme IICB(Glc) phosphorylation by the general PTS proteins and also Enzyme IICB(Glc)-mediated phosphorylation of alpha-methylglucoside. Binding of Mlc to Enzyme IICB(Glc) in vitro required the IIB domain and the IIC-B junction region. Moreover, we show that these same regions are sufficient for Mlc regulation in vivo, via cross-dephosphorylation of IIB(Glc) during transport of other PTS sugars. The control of Mlc activity by sequestration to a transport protein represents a novel form of signal transduction in gene regulation. 相似文献
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The ETS-domain transcription factor family 总被引:2,自引:0,他引:2
Andrew D. Sharrocks A.Louise Brown Yan Ling Paula R. Yates 《The international journal of biochemistry & cell biology》1997,29(12):1371-1387
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