Mapping the Mouse Cell Atlas by Microwell-Seq

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Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter

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A 20-Gene Set Predictive of Progression to Severe Dengue

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Structural Mechanisms Underlying Activity Changes in an AMPA-type Glutamate Receptor Induced by Substitutions in Its Ligand-Binding Domain

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Structure,Function, and Evolution of the Pseudomonas aeruginosa Lysine Decarboxylase LdcA

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Fusion of DARPin to Aldolase Enables Visualization of Small Protein by Cryo-EM

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Comparative Analysis of Droplet-Based Ultra-High-Throughput Single-Cell RNA-Seq Systems

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HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design

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Systems Properties and Spatiotemporal Regulation of Cell Position Variability during Embryogenesis

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DECA,A Comprehensive,Automatic Post-processing Program for HDX-MS Data*

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Highlights

• •Open source software for comprehensive HDX-MS data analysis.
• •Automatic back-exchange correction options.
• •Rigorous statistical analysis of the significance of uptake differences.
• •High quality visualization tools.

     

Dependency of the Cancer-Specific Transcriptional Regulation Circuitry on the Promoter DNA Methylome

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Synapse Formation Activates a Transcriptional Program for Persistent Enhancement in the Bi-directional Transport of Mitochondria

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The Preprotein Binding Domain of SecA Displays Intrinsic Rotational Dynamics

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Whole-Brain Calcium Imaging during Physiological Vestibular Stimulation in Larval Zebrafish

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Topological Organization of Ventral Tegmental Area Connectivity Revealed by Viral-Genetic Dissection of Input-Output Relations

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Nonparametric Analysis of Thermal Proteome Profiles Reveals Novel Drug-binding Proteins*

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Highlights

• •Method for the analysis of response curves from thermal proteome profiling (TPP).
• •NPARC uses nonparametric statistics and provides false discovery-rate (FDR) control.
• •Increased proteome coverage and sensitivity to identify drug-binding proteins.

     

ComplexBrowser: A Tool for Identification and Quantification of Protein Complexes in Large-scale Proteomics Datasets

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Highlights

• •Automated analysis of protein complexes in proteomic experiments.
• •Quantitative measurement of the coordinated changes in protein complex components.
• •Interactive visualizations for exploratory analysis of proteomic results.

     

An Assembly Intermediate Structure of Rice Dwarf Virus Reveals a Hierarchical Outer Capsid Shell Assembly Mechanism

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Comprehensive Analysis of Individual Variation in the Urinary Proteome Revealed Significant Gender Differences

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Highlights

• •Comprehensive analysis of inter-individual variation of normal urinary proteome.
• •Significant gender differences were observed.
• •Proteins increased in female urine are enriched in immunological pathways.
• •Estimated reference intervals of proteins as the baseline for biomarker discovery.