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1.
Fifteen compounds were obtained from the extract of the whole herbs of Aristolochia tagala, which were divided into eight aristolactam-type alkaloids (1–6, 14 and 15) and seven aristolochic acid derivatives (7–13). Their structures were identified as aristolactam BII, aristolactam II, sauristolactam, aristolactam I, 7-methoxyaristolactam IV, aristolactam AII, 3-hydroxy-4-methoxy-10-nitrophenanthrene-1-carboxylic acid methyl ester, ariskanin A, ariskanin D, ariskanin E, aristolochic acid C, ariskanin C, ariskanin B, aristolactam-N-β-D-glucoside and cepharanone A N-β-D-glucoside by comparison of their spectral data with those reported previously in the literature. The chemotaxonomic relationships between A. tagala and other species of genus Aristolochia were also discussed. As a result, the isolated compounds closely matched the ones obtained in other species of the genus.  相似文献   

2.
Several analogs of aristolochic acids were isolated and derivatized into their lactam derivatives to study their inhibition in CDK2 assay. The study helped to derive some conclusions about the structure–activity relation around the phenanthrin moiety. Semi-synthetic aristolactam 21 showed good activity with inhibition IC50 of 35 nM in CDK2 assay. The activity of this compound was comparable to some of the most potent synthetic compounds reported in the literature.  相似文献   

3.
Separation of the basic fractions from Formosan Fissistigma glaucescens, F. oldhamii and Goniothalamus amuyon afforded one new quaternary phenanthrene alkaloid, N-methylatherosperminium (15), along with the known alkaloids, (?)-discretamine (1), (?)-tetrahydropalmatine (2), palmatine (3), (?)-asimilobine (4), (?)-norannuradhapurine (5), (?)-crebanine (6), (?)-calycinine (fissoldine, fissistigine A) (7a), (?)-anolobine (8), (?)-xylopine (9), (?)-anonaine (10a), oxocrebanine (11), liriodenine (12), atherosperminine (13), N-noratherosperminine (14) and (+)-O-methylflavinantine (O-methylpallidine) (16).  相似文献   

4.
Recent molecular phylogenetic analyses indicate that Dubyaea glaucescens (Compositae–Cichorieae) should be transferred to the genus Faberia as F. glaucescens. Here, we present cytological evidence for this transfer. Dubyaea glaucescens comprises two ploidy levels, 2n = 34 (diploid) and 2n = 51 (triploid), making the basic chromosome number x = 17. The chromosomes vary in length from 5.82 μm to 2.11 μm, and the karyotypes are 2n = 20m + 14sm (3sat) for the diploid cytotype and 2n = 30m + 21sm (3sat) for the triploid cytotype. Karyological characters of D. glaucescens, including chromosome number, size, morphology, and karyotype asymmetry, all agree remarkably with those reported previously in Faberia, but are distinct from those in other species of Dubyaea. The transfer of D. glaucescens to Faberia is thus strongly corroborated.  相似文献   

5.
The chemical investigation of whole plants Piper boehmeriifolium (Miq.) Wall. ex C. DC. led to the isolation of 22 compounds, including two lignans (12), sixteen amide alkaloids (318), one diterpene (19), two monoterpenes (2021), and one phenylpropanoid (22). Their structures were elucidated by extensive spectroscopic analyses including NMR, MS, and by comparison with the literature. Compounds 12, 67, 1112, 14, and 1722 were firstly isolated from P. boehmeriifolium, while compounds 2, and 1920 were isolated from Piper genus for the first time. The chemotaxonomic significance of these isolated compounds is discussed.  相似文献   

6.
Siphonoids A–C (13), among which siphonoids A-B (1–2) are rare (E)-p-coumaroyl iridoids, were isolated from Siphonostegia chinensis along with ten known iridoids (413) and four lignans (14–17). The structures of the compounds were established by 1D- and 2D-NMR spectroscopy and mass spectrometry. Most of the iridoids isolated from S. chinensis were found to possess (E)-p-coumaroyl iridoid subtype skeletons. Hence, this type of iridoid could be regarded as a chemotaxonomic marker of S. chinensis. The inhibition activities for the NF-κB pathway of iridoids (16) were detected. The present results showed that compounds 12 and 4–6 processed moderate activity towards the inhibition of NF-κB.  相似文献   

7.
A series of natural aristolactams and their analogues have been prepared and evaluated for antitumor activity against human cancer cells, including multi-drug resistant cell lines. Naturally occurring aristolactams, such as aristolactam BII (cepharanone B), aristolactam BIII, aristolactam FI (piperolactam A), N-methyl piperolactam A, and sauristolactam showed moderate antitumor activities in selected cell lines. However, several synthetic aristolactam derivatives exhibited potent antitumor activities against a broad array of cancer cell lines with GI50 values in the submicromolar range.  相似文献   

8.
The novel cucurbitacins, balsaminagenin A and B (12) and balsaminoside A (3) and the know cucurbitacin karavelagenin C (4), together with five new mono or diacylated derivatives (59) of karavelagenin C were evaluated for multidrug resistance reversing activity on human MDR1 gene transfected mouse lymphoma cells. Compounds 26 exhibited a strong activity compared with that of the positive control, verapamil. Structure–activity relationships are discussed. Moreover, in the checkerboard model of combination chemotherapy, the interaction between doxorubicin and compounds 25 synergistically enhanced the effect of the anticancer drug. Compounds 14 were isolated from the aerial parts of Momordica balsamina L. The structures of the compounds were established on the basis of spectroscopic methods including 2D NMR experiments (COSY, HMQC, HMBC and NOESY).  相似文献   

9.
Three pairs of new N-methoxy-containing indolediketopiperazine enantiomers, acrozines A–C (13), were isolated from the culture extract of Acrostalagmus luteoalbus TK-43, an endophytic fungus obtained from the marine green alga Codium fragile. The optical resolution of compounds 13 by chiral HPLC successfully afforded individual enantiomers (+)-1/(–)-1, (+)-2/(–)-2, and (+)-3/(–)-3, respectively. The structures of all these compounds were established on the basis of detailed interpretation of their NMR and mass spectroscopic data. X-ray crystallographic analysis confirmed the structures of compounds 13, while the absolute configurations were determined by TDDFT-ECD calculations. All these compounds containing a N-methoxy group which is uncommon in indolediketopiperazines. The enantiomers, (+)-2/(–)-2, showed different antimicrobial activities against several plant-pathogenic fungi, while (+)-1 displayed better inhibitory activity against acetylcholinesterase than that of (–)-1.  相似文献   

10.
Four new flavonoid glycosides, curcucomosides A–D (14), three known flavonoid glycosides, 57, and four known diarylheptanoids, 811, were isolated from the ethanol extract of the aerial parts of Curcuma comosa. The structures of the new compounds were established as rhamnazin 3-O-α-l-arabinopyranoside (1), rhamnocitrin 3-O-α-l-arabinopyranoside (2), rhamnazin 3-O-α-l-rhamnopyranosyl-(1→2)-O-α-l-arabinopyranoside (3), and rhamnocitrin 3-O-α-l-rhamnopyranosyl-(1→2)-O-α-l-arabinopyranoside (4) by spectroscopic analysis and chemical reactions whereas those of the known compounds were identified by spectral comparison with those of the reported values.  相似文献   

11.
One new flavonoid, named (R)-2-hydroxynaringenin (1), along with fifteen known compounds, including six flavonoids (27), six lignans (813), two phenolic glycosides (1415) and one alkaloid (16) were isolated from the roots of Zizyphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou. Their structures were established on the basis of spectroscopic evidence, including 1D and 2D NMR, circular dichroism (CD) curve analysis, and by comparison with literature data. Compounds 2, 3 and 816 were found in Z. jujuba Mill. var. spinosa for the first time, while compounds 8, 10 and 1315 were new to the Rhamnaceae family. In addition, the chemotaxonomic significance of the isolates was discussed in this paper.  相似文献   

12.
Phytochemical investigation of the n-butanol fraction of Evolvulus alsinoides (Linn.) led to the isolation of three new phenolic glycosides, evolvosides C, D and E (13) along with six known compounds (49). The structures of the compounds were elucidated on the basis of spectroscopic analysis, viz. 1D and 2D NMR experiments, chemical study, and comparison with literature data. Evolvoside C (1) was characterized as kaempferol 4′-O-β-d-glucopyranosyl-(1→2)-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside, whereas evolvosides D and E (23) were found to be mono and di-O-methyl derivatives of 1. The new compounds (1–3) represent rare triglycoside derivatives of flavonol at C-4′. The isolated compounds (16) were screened for acute stress-induced biochemical changes in male Sprague–Dawley rats at a dose of 40 mg/kg body weight. Compounds 1 and 2 displayed anti-stress effects by normalizing hyperglycemia, plasma corticosterone, plasma creatine kinase, and adrenal hypertrophy. Compounds 3 and 6 were also found to be effective in normalizing most of these stress parameters, whereas compounds 4 and 5 were ineffective in normalizing most of these effects.  相似文献   

13.
The phytochemical study of Piper pleiocarpum Chang ex Tseng led to the isolation of eighteen compounds (118), including ten lignanoids, galbelgin (1), (+) sesamin (2), denudatin A (3), hancinone (4), (7S,8S, 3′R)-Δ8'-3,3′,4-trimethoxy-3′,6′-dihydro-6′-oxo-7.0.4′,8.3′-lignan[(2S,3S,3aR)-2-(3,4-dimethoxyphenyl)-3,3a-dihydro-3a-methoxy-3-methyl-5-(2-propenyl)-6(2H))-benzofuranone] (5), (−)-(7R,8R)-machilin D (6), (1R,2R)-2-[2-methoxy-4-((E)-prop-1-enyl)phenoxy]-1-(3,4-dimethoxyphenyl)propyl acetate (7), piperbonin A (8), machilin D (9), 4-methoxymachilin D (10), one amide alkaloid, Δα,β-dihydropiperine (11), six polyoxygenated cyclohexenes, ent-curcuminol F (12), uvaribonol E (13), ellipeiopsol A (14), 1S,2R,3R,4S-1-ethoxy-2-[(benzoyloxy)methyl]cyclohex-5-ene-2,3,4-triol, 3-acetate (15), (+)-crotepoxide (16), (+)-senediol (17), and one benzoate derivative, 2-acetoxybenzyl benzoate (18). Their structures were established by spectroscopic data and by comparison with the literature. All the compounds were firstly isolated from P. pleiocarpum, while ten compounds 67, 910, 1215, 1718 were isolated from the genus Piper and the family Piperaceae for the first time. The chemotaxonomic significance of these compounds was also discussed. The isolation of compounds 67, 910 may be used as chemotaxonomic markers for the genus of Piper.  相似文献   

14.
Trimellitimides 621 were prepared and investigated in vivo for anti-inflammatory and ulcerogenic effects and in vitro for cytotoxicity. They were subjected to in vitro cyclooxygenase (COX-1/2) and carbonic anhydrase inhibition protocols. Compounds 611 and 18 exhibited anti-inflammatory activities and had median effective doses (ED50) of 34.3–49.8 mg kg−1 and 63.6–86.6% edema inhibition relative to the reference drug celecoxib (ED50: 33.9 mg kg−1 and 85.2% edema inhibition). Compounds 611 and 18 were weakly cytotoxic at 10 μM against 59 cell lines compared with the reference standard 5-fluorouracil (5-FU). Compounds 611 had optimal selectivity against COX-2. The selectivity index (SI) range was >200–490 and was comparable to that for celecoxib [COX-2 (SI) > 416.7]. In contrast, compounds 12, 13, and 1618 were nonselective COX inhibitors with a selectivity index range of 0.92–0.25. The carbonic anhydrase inhibition assay showed that sulfonamide incorporating trimellitimides 611 inhibited the cytosolic isoforms hCA I and hCA II, and tumor-associated isoform hCA IX. They were relatively more susceptible to inhibition by compounds 8, 9, and 11. The KI ranges were 54.1–81.9 nM for hCA I, 25.9–55.1 nM for hCA II, and 46.0–348.3 nM for hCA IX. © 2018 Elsevier Science. All rights reserved.  相似文献   

15.
Eighteen secondary metabolites were isolated from the fermentation broth of the endophytic fungus Xylaria sp. SYPF 8246, including four new compounds, xylarianins A-D (14), three new natural products, 6-methoxycarbonyl-2-methyl-3,5,4′,6-tetramethoxy-diphenyl ether (5), 2-chlor-6-methoxycarbonyl-2-rnethyl-3,5,4′,6-tetramethoxy-diphenyl ether (6), and 2-chlor-4-hydroxy-6-methoxy carbonyl-2-methyl-3,5,6-trimethoxy-diphenyl ether (7), and eleven known compounds (818). Their structural elucidations were conducted by using 1D and 2D NMR, HRESIMS, and Rh2(OCOCF3)4-induced electronic circular dichroism (ECD) spectra analyses. The integrated 1H and 13C NMR data of three new natural products 57 were reported for the first time. All the isolated compounds were assayed for their inhibitory activities against human carboxylesterase 2 (hCE 2). Compounds 1, 59, and 18 displayed significant inhibitory activities against hCE 2 with IC50 values of 10.43 ± 0.51, 6.69 ± 0.85, 12.36 ± 1.27, 18.25 ± 1.78, 29.78 ± 0.48, 18.86 ± 1.87, and 20.72 ± 1.51 µM, respectively. The interactions between compounds 1 and 5 with hCE 2 were anaylzed by molecular docking.  相似文献   

16.
A new lignanoid (1), together with six known lignanoids (2–7) and four known flavonoids (8–11), were isolated from the EtOAc extract of Liparis japonica. Their structures were determined by analyzing the HRESIMS, NMR, CD spectroscopic data, and comparing with the reported literatures. Among them, 1 was a new compound, 2–11 were first isolated from L. japonica and the genus of Liparis. The chemotaxonomic significance of these isolates was comprehensively discussed.  相似文献   

17.
Two new N-benzoylamino acids, peniginseng A-B (12), and two new fatty acids, peniciginseng A-B (56), were isolated during the fermentation of Penicillium sp. YIM PH30003, an endophytic fungus associated with Panax notoginseng (Burk.) F.H. Chen. Their structures were assigned based on a combination of 1D and 2D NMR and mass spectral data. The N-benzoylamino acids (14) might share similar biosynthetic pathways with the rare siderophore pistillarin. Compounds 110 showed antifungal activities (MICs 16–128 μg/mL) against Fusarium solani, the pathogenic fungus of P. notoginseng.  相似文献   

18.
A series of novel 2-(1,2,3-triazolylmethoxy) 5aq and isoxazole tagged 6ag 2H-Chromene derivatives were prepared starting from salicylaldehyde and ethyl-4,4,4-trifluoroacetoacetate via cyclization to form ethyl 2-hydroxy-2-(trifluoromethyl)-2H-Chromene-3-carboxylate 3. Compound 3 on reaction with propargyl bromide resulted compound 4 and was independently reacted with aryl/alkyl azides and aryl aldoximes obtained 2-(1,2,3-triazolylmethoxy) and isoxazole tagged 2H-Chromene derivatives 5aq, 6ai, respectively. Compounds 6 were further hydrolysed to acid derivatives 7ag. All the products 5aq, 6ai, 7ag were screened for cytotoxic activity against four human cancer cell lines and among all the compounds, 5f, 5g, 5l, 5q showed promising activity at <20 μM concentration.  相似文献   

19.
Euphoroids A–C (13), three new ent-abietane-type diterpenoids, together with ten known analogues (413) were obtained from the roots of Euphorbia ebracteolata. The structures of these compounds were determined by extensive spectroscopic data analysis, including UV, HRESIMS, 1D-, and 2D-NMR data. The inhibitory effects of compounds 113 on human cancer cells were determined using the MTT assay. The results revealed that new compounds 2 and 3 showed moderate cytotoxic activities against human cancer cell lines. Especially, compound 3 displayed selective cytotoxic effect agains cancer cell lines.  相似文献   

20.
One new monoterpenoid glycoside (1), together with seven known compounds, including two alkaloids (23), three phenylpropanoids (46), and two nucleosides (78) were isolated from the calyces of Physalis alkekengi var. franchetii. Their structures were elucidated by a combination of detailed spectroscopic analyses, chemical methods, and comparison with reported data. These eight compounds were isolated for the first time from the genus Physalis. The chemotaxonomic significance of these compounds was summarized.  相似文献   

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