共查询到20条相似文献,搜索用时 31 毫秒
1.
2.
3.
《Autophagy》2013,9(4):434-435
Interventions that reduce infarct size in animal models have largely failed to improve outcome in patients suffering acute myocardial infarction (MI), or ‘heart attack’. Our group recently reported a reduction of infarct size by chloramphenicol treatment in a porcine in vivo model of acute MI, through a mechanism involving the induction of autophagy. Since 2005 several studies have implicated autophagy as a target for cardioprotection. 相似文献
4.
Cooperation through interdependence 总被引:2,自引:0,他引:2
Gilbert Roberts 《Animal behaviour》2005,70(4):901-908
5.
6.
7.
8.
Doerr A 《Nature methods》2011,8(9):711
Two groups present small molecule–induced degradation systems for controlling protein function in living systems. 相似文献
9.
Strength through diversity 总被引:1,自引:0,他引:1
The remarkable versatility of the mammalian brain is made possible by a huge diversity of cellular plasticity mechanisms. These include long-term potentiation and depression at both excitatory and inhibitory synapses, as well as a variety of intrinsic and homeostatic plasticity mechanisms. A fundamental challenge for the field is to assemble our detailed knowledge of these specific mechanisms into a coherent picture of how plasticity within cortical circuits works to tune network properties. 相似文献
10.
11.
12.
13.
14.
15.
The permeability of the cornea to drugs is clinically important because it is the major factor determining the efficacy of topically applied ophthalmic preparations. With this perspective, the present article gives a brief update and overview of corneal structure and proposed mechanisms of permeation. Physiological, physicochemical and formulation factors affecting drug permeation through cornea are highlighted. Influence of ocular penetration enhancers on drug permeation is also discussed. 相似文献
16.
17.
18.
19.