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A cis-acting transcription element of the c-myc gene can assume an H-DNA conformation 总被引:10,自引:4,他引:6
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A J Kinniburgh 《Nucleic acids research》1989,17(19):7771-7778
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The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression 总被引:6,自引:0,他引:6
Liu J Kouzine F Nie Z Chung HJ Elisha-Feil Z Weber A Zhao K Levens D 《The EMBO journal》2006,25(10):2119-2130
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Enrichment of four tandem repeats of guanine (G) rich and cytosine (C) rich sequences in functionally important regions of human genome forebodes the biological implications of four-stranded DNA structures, such as G-quadruplex and i-motif, that can form in these sequences. However, there have been few reports on the intramolecular formation of non-B DNA structures in less than four tandem repeats of G or C rich sequences. Here, using mechanical unfolding at the single-molecule level, electrophoretic mobility shift assay (EMSA), circular dichroism (CD), and ultraviolet (UV) spectroscopy, we report an intramolecularly folded non-B DNA structure in three tandem cytosine rich repeats, 5'-TGTC4ACAC4TGTC4ACA (ILPR-I3), in the human insulin linked polymorphic region (ILPR). The thermal denaturation analyses of the sequences with systematic C to T mutations have suggested that the structure is linchpinned by a stack of hemiprotonated cytosine pairs between two terminal C4 tracts. Mechanical unfolding and Br(2) footprinting experiments on a mixture of the ILPR-I3 and a 5'-C4TGT fragment have further indicated that the structure serves as a building block for intermolecular i-motif formation. The existence of such a conformation under acidic or neutral pH complies with the strand-by-strand folding pathway of ILPR i-motif structures. 相似文献
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