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Abstract The effect of pyrimidine base substitution on the sensitivity of oligonucleotides to nucleases has been studied with two series of self complementary deoxyoligonucleotides containing n-alkyl, n-(1-alkenyl) or n-(1-alkynyl) groups at C5 of pyrimidines, (dA-r5dU)10 and (dG-rsdC)6. The rate of hydrolysis by snake venom phosphodiesterase and in human serum decreased with increasing length and unsaturation of the substituent. 相似文献
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C. Babin 《Marine Micropaleontology》1986,10(4)
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David Jablonski 《Journal of evolutionary biology》1992,5(2):357-359
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《Basic and Applied Ecology》2014,15(3):277-278
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Matthias Schaefer 《Basic and Applied Ecology》2009,10(8):771
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