共查询到20条相似文献,搜索用时 0 毫秒
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C Mayaud W Rozenbaum J L Touboul G Akoun 《Revue fran?aise de transfusion et immuno-hématologie》1984,27(4):411-421
Numerous clinical and immunological manifestations are commonly observed in AIDS patients. Among these, Kaposi's sarcoma and major opportunistic infections appear today as clinical "markers" of the disease. Other signs and symptoms such as fever, diarrhea, lymphadenopathy and immunological abnormalities are currently recognized as "associated" disorders. One of the main problems faced by clinicians is to evaluate the significance of these "associated" abnormalities, especially when they occur in at risk populations. Much work is still needed to clarify whether they actually imply an individual predisposition to contract the disease, a minor form or some early stage of AIDS. 相似文献
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钠通道及其相关疾病综合征 总被引:2,自引:1,他引:2
钠通道是分布于可兴奋性细胞膜上的一种重要的阳离子通道,其开放控制着动作电位的去极化相,并积极参与了细胞的兴奋、收缩、分泌和突触传递等高度有序的特异性功能。最近研究表明许多困扰人类的家族性遗传病就是因为钠通道发生了基因突变而引起的。简要地综述了钠通道的结构及其目前已发现的相关疾病综合征。并描述了从动物毒素中获取治疗药物的应用前景。 相似文献
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Blease C 《Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences》2010,41(4):333-339
This paper aims to show that the classification by the American Psychiatric Association (APA) in the Diagnostic and Statistical Manual of Mental Disorders (DSM) of a distinct listing of disorders known as Culture-Bound Syndromes (CBS) is misguided. I argue that the list of CBS (in Appendix I of the manual) comprises either (a) genuine disorders that should be included within the main body of the DSM; or (b) ersatz-disorders that serve a practical role for psychiatrists dealing with patients from certain cultures but will one day be eliminated or assimilated by bona fide DSM classifications. In support of these views I draw on claims from two key themes in the philosophy of science: (1) the claim that all folk (that is, non-scientific) explanations for phenomena are thoroughly theoretical and therefore fallible; and (2) the occurrence of theoretical elimination in the history of science. I contend that any ersatz-disorders located in the DSM that are judged to be radically false do not differ in kind from eliminated theories in the history of pre-science. 相似文献
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A 25-year-old man with hemophilia who had been treated primarily with cryoprecipitate presented with epigastric pain and loose, melenic stools. He had a long history of malaise and intermittent upper respiratory tract infection with fever. The patient was shown to have disseminated histoplasmosis and refractory herpes simplex. Immunologic studies demonstrated a markedly decreased ratio of helper to suppressor T cells, lymphopenia, cutaneous anergy and a slightly elevated serum IgA level. These findings met the criteria for the diagnosis of acquired immune deficiency syndrome. In addition, antibodies to human T-cell leukemia virus were detectable in the serum. 相似文献
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Y Laurian T Lambert M J Larrieu 《Revue fran?aise de transfusion et immuno-hématologie》1984,27(4):493-496
The occurrence during the last 2 years of 29 cases of AIDS in hemophiliacs (21 in USA and 8 in Europe) suggests possible transmission of this disease by blood products. All these patients had received Factor VIII or IX concentrates and developed pneumocystis carinii pneumonia or other opportunistic infections. Kaposi's sarcoma was not observed in any patient. Recent studies have focused on the frequency of AIDS-related complex in hemophiliacs, which may arise as a crucial problem. However this does not justify at the moment any reduction in the substitutive treatment of hemophiliac patients unless new clues to the understanding of these disorders are provided. Therefore, it is mostly important to clearly define, through research programs and precise follow-up of patients, blood products which can be used safely in hemophiliacs. 相似文献
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G B C?té 《Annales de génétique》1989,32(2):69-72
The major role of somatic crossing-over in the aetiology of Wilms' tumour and other forms of cancer is emphasized. A model is proposed to show that tumour development is due to a cis-trans disruptive effect of somatic crossing-over on the maintenance of differential parental imprinting. 相似文献
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Merrill Singer 《Medical anthropology quarterly》2000,14(3):445-448
Notes on the Plague Years: AIDS in Marseilles. Bernard Paillard (Berkeley Frank, trans.). New York: Aldine de Gruyter, 1998. xxx. 293 pp.
Putting Risk in Perspective: Black Teenage Lives in the Era of AIDS. Renée T. White. Lanham, MD: Rowman & Littlefield Publishers, 1999. xii. 215 pp.
The AIDS Crisis:. Documentary History. Douglas A. Feldman and Julia Wang Miller. eds. Westport, CT: Greenwood, 1998. xlii. 266 pp.
Global Responses to AIDS: Science in Emergency. Cristiana Bastos. Bloomington: Bloomington: Indiana University Press, 1999. xx. 225 pp. 相似文献
Putting Risk in Perspective: Black Teenage Lives in the Era of AIDS. Renée T. White. Lanham, MD: Rowman & Littlefield Publishers, 1999. xii. 215 pp.
The AIDS Crisis:. Documentary History. Douglas A. Feldman and Julia Wang Miller. eds. Westport, CT: Greenwood, 1998. xlii. 266 pp.
Global Responses to AIDS: Science in Emergency. Cristiana Bastos. Bloomington: Bloomington: Indiana University Press, 1999. xx. 225 pp. 相似文献