On the significance of presumptions in phylogenetics (regarding the paper of Pesenko, 2005. Zhurnal Obshchei Biologii. V. 66. No 2)

Under brief consideration is the uses of presumptions, as a kind of a priori judgments, in phylogenetics in light of their critics by Pesenko (2005). It is shown that the concept of presumption is fully compatible with the hypothetic-deductive argumentation scheme allowing to realize the parsimony principle in its epistemic interpretation. System of phylogenetic presumptions deserves future development in the framework of construing phylogenetics as a kind of the informal axiomatics.     

An old paper revisited: "a mathematical model of carbohydrate energy metabolism. Interaction between glycolysis, the Krebs cycle and the H-transporting shuttles at varying ATPases load" by V.V. Dynnik, R. Heinrich and E.E. Sel'kov

We revisit an old Russian paper by V.V. Dynnik, R. Heinrich and E.E. Sel’kov (1980a, b) describing: “A mathematical model of carbohydrate energy metabolism. Interaction between glycolysis, the Krebs cycle and the H-transporting shuttles at varying ATPases load”. We analyse the model mathematically and calculate the control coefficients as a function of ATPase loads. We also evaluate the structure of the metabolic network in terms of elementary flux modes.We show how this model can respond to an ATPase load as well as to the glucose supply. We also show how this simple model can help in understanding the articulation between the major blocks of energetic metabolism, i.e. glycolysis, the Krebs cycle and the H-transporting shuttles.