Polyploid mitosis and depolyploidization promote chromosomal instability and tumor progression in a Notch-induced tumor model

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Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis,transitions between metabolic states,and their regulatory mechanisms

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TMEM127 suppresses tumor development by promoting RET ubiquitination,positioning, and degradation

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Lineage tracing reveals the phylodynamics,plasticity, and paths of tumor evolution

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Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

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Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin

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Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors

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Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions

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Molecular,metabolic, and functional CD4 T cell paralysis in the lymph node impedes tumor control

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The Mitochondrial Protein MAVS Stabilizes p53 to Suppress Tumorigenesis

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Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer

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Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2

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The role of lipids in cancer progression and metastasis

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Plexin-B3 expression stimulates MET signaling,breast cancer stem cell specification,and lung metastasis

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Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells

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Glioblastoma hijacks neuronal mechanisms for brain invasion

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NR4A1 regulates expression of immediate early genes,suppressing replication stress in cancer

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Discovering dominant tumor immune archetypes in a pan-cancer census

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Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche

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Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion

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