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Disruption of largest subunit RNA polymerase II genes in Trypanosoma brucei. 总被引:4,自引:1,他引:3 下载免费PDF全文
H M Chung M G Lee P Dietrich J Huang L H Van der Ploeg 《Molecular and cellular biology》1993,13(6):3734-3743
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VSG gene 118 is transcribed from a cotransposed pol I-like promoter 总被引:31,自引:0,他引:31
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In trypanosomes the homolog of the largest subunit of RNA polymerase II is encoded by two genes and has a highly unusual C-terminal domain structure 总被引:21,自引:0,他引:21
We have isolated the genes encoding the largest subunit of all three classes of RNA polymerase from Trypanosoma brucei. While the pol II largest subunit is encoded by a single gene in all organisms examined to date, trypanosomes contain two copies of the gene. Both genes are expressed in the procyclic and bloodstream stages of the trypanosome life cycle. The two pol II genes differ from one another in their coding sequences by 21 silent substitutions and 4 amino acid substitutions. In the core part of the large subunit, the predicted polypeptides are similar to other eukaryotic RNA polymerases. Both trypanosome pol II polypeptides, like those of other eukaryotes, also have a unique C-terminal extension. However, this domain in the trypanosome polypeptides, unlike those of other eukaryotes, is not a tandemly repeated heptapeptide sequence. 相似文献
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Transcription elongation factor SII 总被引:9,自引:0,他引:9
Wind M Reines D 《BioEssays : news and reviews in molecular, cellular and developmental biology》2000,22(4):327-336