共查询到20条相似文献,搜索用时 0 毫秒
1.
Characterization of the upstream mouse Cbfa1/Runx2 promoter 总被引:9,自引:0,他引:9
2.
Galindo M Pratap J Young DW Hovhannisyan H Im HJ Choi JY Lian JB Stein JL Stein GS van Wijnen AJ 《The Journal of biological chemistry》2005,280(21):20274-20285
3.
4.
Alcantara EH Shin MY Sohn HY Park YM Kim T Lim JH Jeong HJ Kwon ST Kwun IS 《The Journal of nutritional biochemistry》2011,22(11):1055-1063
5.
6.
7.
Drissi H Pouliot A Koolloos C Stein JL Lian JB Stein GS van Wijnen AJ 《Experimental cell research》2002,274(2):323-333
8.
9.
10.
Histone deacetylases (HDACs) deacetylate lysine residues of histone and non-histone proteins and thereby regulate the cell-cycle,
gene expression, and several other processes. We have analyzed the effects of HDAC1 on Runx2-mediated regulation of osteopontin
(OPN) promoter activation and gene expression in mesenchymal progenitor C3h10t1/2 cells and show that co-expression of HDAC1
along with Runx2 results in down-regulation of Runx2-induced OPN mRNA expression during both the proliferation and differentiation
stages of C3h10t1/2 cells. Luciferase assay results revealed that HDAC1 efficiently down-regulated Runx2-stimulated OPN promoter
activity in a dose-dependent manner whereas TSA relieved the HDAC1-mediated repression and up-regulated the Runx2-induced
OPN promoter activity and mRNA expression. In vivo HDAC1 co-localized and physically interacted with Runx2 and associated
with the OPN promoter. Thus, HDAC1 not only plays a critical role in regulation of Runx2-stimulated expression of osteogenic
genes, like OPN, but also regulate the proliferation and differentiation stages of mesenchymal progenitor cells, such as C3h10t1/2. 相似文献
11.
12.
13.
14.
Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity 下载免费PDF全文
Sierra J Villagra A Paredes R Cruzat F Gutierrez S Javed A Arriagada G Olate J Imschenetzky M Van Wijnen AJ Lian JB Stein GS Stein JL Montecino M 《Molecular and cellular biology》2003,23(9):3339-3351
15.
16.
17.
18.
19.