Laureates of the Palladin Premium of the National Academy of Science of Ukraine

The article presents a short information about the Resolution of Ukr.SSR Soviet of Ministers on establishing the nominal premium of Presidium the Academy of Sciences of Ukr.SSR (of NAS of Ukraine, now) in the field of biochemistry and molecular biology dedicated to the famous scientists, founder of the Ukrainian biochemical school and the Institute of Biochemistry named after him--academician O. V. Palladin. There is a chronologically sequential list presenting all Laureates (with photo pictures) awarded by this honourable bonus with displaying their scientific works for which they received this reward.     

An analysis of the scientific publications of the A. A. Bogomolets Institute of Physiology of the Academy of Sciences of Ukraine]

Scientific publications from three sectors of the Institute have analyzed for the period since 1979 till 1988 inclusive. The analysis is based on data of annual reference books Science Citation Index (SCI) and lists of publications of each researcher of the Institute. It is shown that with almost equal numerical strength of researchers and similar number of publications the sector of molecular physiology contributed 43.6% to cited works 48.2% of these works are included into database of SCI. Such indices for the sectors of neurophysiology and physiology of visceral systems accounted for 33%, 33.4% and 23.4, 18.4% respectively. It is of interest that 47.5% of references to the cited works of the molecular physiology sector were made by foreign scientists and self-citation constituted 17.4%, while for the other sectors such indices had a reverse relationship. The problem on objectification of estimation of research is under discussion.     

Institute of Biochemistry and the development of molecular biophyics in the Ukraine

The development of molecular biophysics research in Ukraine is reviewed with historical perspective. Vladimir Belitser and his school were among the pioneers in the studies of protein denaturation and assembly of intermolecular structures. New methods of research of protein conformational transitions and dynamics at equilibrium have been developed at the Palladin Institute of Biochemistry. Presently, the biophysics aspects in different areas of protein research are actively explored. The studies of protein folding in both experimental and theoretical aspects promise especially good prospects.     

O.V. Palladin Institute of Biochemistry of the Ukrainian National Academy of Sciences--75 years

The article deals with a short record including the information about the history of creation and main developmental stages of the first and presently the single in Ukraine Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine. The record contains the main achievements of the Institute scientific subdivisions for the 75 years period of their creative work in the field of the most urgent problems of fundamental and applied biochemistry. As well it displays the information about comprehensive and extensive publishing and educational activity conducted by the staff,, the work on training the scientific manpower of the highest qualification--Doctors of Science (D.Sc.) and Philosophy Doctors (Ph. D.), active participation of the research scientists in attracting to science the talented young people representing the students and school-children taking interest in the biological chemistry. The article shows the great role of the Institute famous scientists-biochemists in forming some scientific schools on functional biochemistry acknowledged in the world biochemistry. There are also some data about the each of nine scientific departments of the Institute for the period of last 20-25 years of their activity in the field of the most urgent problems of the contemporary biochemistry. These are the following Departments: Neurochemistry, Metabolism Regulation, Muscular Biochemistry, Protein Structure Functions, Coenzymes Biochemistry, Enzymes Chemistry and Biochemistry, Molecular Immunology, Biochemistry of Lipids, Sensor and Regulator Systems Biochemistry. There is also a short review regarding the history of foundation, development and scientific achievements of the Institute division in L'viv including four scientific departments: Biochemistry of Cellular Differentiation, Biochemical Genetics, Regulation of Low Molecular Compounds Synthesis, Regulation of Cells Differentiation.     

Biochemical features of cancer cachexia under conditions of different provision with vitamin A

On the model of tumor growth of Guerin's carcinoma and experimental modeling of vitamin A provision the biochemical characteristics of tumor cachexia in animals with malignant tumors and different vitamin A provision status were studied. It is determined that tumor growth in the body, deprived of vitamin A, is characterized by negative nitrogen balance, decrease of glucose, free fatty acids and ketone bodies level in the blood serum, which indicates the increase of cancer cachexia.     

Palladin regulation of the actin structures needed for cancer invasion

Cell migration and invasion involve the formation of cell adhesion structures as well as the dynamic and spatial regulation of the cytoskeleton. The adhesive structures known as podosomes and invadopodia share a common role in cell motility, adhesion, and invasion, and form when the plasma membrane of motile cells undergoes highly regulated protrusions. Palladin, a molecular scaffold, co-localizes with actin-rich structures where it plays a role in their assembly and maintenance in a wide variety of cell lines. Palladin regulates actin cytoskeleton organization as well as cell adhesion formation. Moreover, palladin contributes to the invasive nature of cancer metastatic cells by regulating invadopodia formation. Palladin seems to regulate podosome and invodopodia formation through Rho GTPases, which are known as key players in coordinating the cellular responses required for cell migration and metastasis.     

Palladin regulation of the actin structures needed for cancer invasion

Cell migration and invasion involve the formation of cell adhesion structures as well as the dynamic and spatial regulation of the cytoskeleton. The adhesive structures known as podosomes and invadopodia share a common role in cell motility, adhesion, and invasion, and form when the plasma membrane of motile cells undergoes highly regulated protrusions. Palladin, a molecular scaffold, co-localizes with actin-rich structures where it plays a role in their assembly and maintenance in a wide variety of cell lines. Palladin regulates actin cytoskeleton organization as well as cell adhesion formation. Moreover, palladin contributes to the invasive nature of cancer metastatic cells by regulating invadopodia formation. Palladin seems to regulate podosome and invodopodia formation through Rho GTPases, which are known as key players in coordinating the cellular responses required for cell migration and metastasis.